Toxoplasma Gondii Related Programmed Cell Death (Pd1 and Pd-L1) in Patients with Diabetes Mellitus
Keywords:
Toxoplasma gondii, Diabetes mellitus, ELISA, PD-1, PD-L1Abstract
Toxoplasma gondii is one of the most successful microorganisms on Earth due to its highcompatibility with a wide range of host species, including mammals, Diabetes mellitus is a
worldwide condition, however it is more prevalent in the industrialized nations. According to the
International Diabetes Federation's most recent estimates for 2019, there are currently an estimated
537 million adults living with diabetes worldwide.in Iraq more than 13.9% of adult live with
diabetes . The main objective of the current study is to verify the presence of immunosera in
diabetic patients against Toxoplasma gondii infection and its relationship with role programmed
death (PD-1) and programmed death ligand ( PD-L1 ) in patients .One hundred twenty (120)
serum sample take from diabetic patients match with 60 control group were obtained and tested
using widely available enzyme immunoassay kits for anti-Toxolasma IgG. The total infection with
toxoplasmosis among patients with DM was 42(35%). Sandwich ELISA technology were used to
explain the level PD-1and PD-L1 and the result were found a high level of pd-1 and pd-l1 in
patient compared with control .
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