The Activity of Salvadora Persica Extracts as Antioxidant and Antimicrobial

Authors

  • Hala Sabry Al-Atbi Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq

Keywords:

Salvadora persica, Miswak, Antimicrobial, Antioxidant

Abstract

Herbal medicine is an effective treatment for many diseases that are intractable to traditional
medicine. Salvadora persica L. is an extensively utilized plant by many Arab populations
worldwide due to its varied medical benefits. The study looks at plant roots' antimicrobial and
free radical scavenging properties of flavonoid, glycoside, and alkaloid extracts. The activity of
the extracts was evaluated for Escherichia coli, Staphylococcus aureus, Pseudomonas
aeruginosa, and Candida albicans. Based on the findings, the three extracts recorded no activity
towards the selected microorganisms except the flavonoid extract which showed an efficacy
close to that of amoxicillin against Staphylococcus aureus and Escherichia coli growth with
inhibition zones 14mm and 15mm respectively. Inhibiting lipid peroxidation was more
successfully accomplished by flavonoid extract which recorded 50% compared to standard
compound BHT (60%), the glycoside and alkaloid extracts exhibited noticeable activity as
antioxidant with 27% and 18.4 % inhibition.

References

- A. Nordin, A. Bin Saim, R. Ramli, A. Abdul Hamid, NW. Mohd Nasri, and R. Idrus,

Miswak and oral health: An evidence-based review Saudi J. Biol. Sci.,; 27: 1801–1810. (2020).

- R. Ahmadi, B. Ghanbarzadeh, A. Ayaseh, HS. Kafil, H. Ozyurt, A. Katourani, and A.

Ostadrahimi, The antimicrobial bio-nanocomposite containing nonhydrolyzed cellulose

nanofiber (CNF) and Miswak (Salvadora persica L.) extract. Carbohydr. Polym. (2019).

- A. Sharma, P. Ranga, S. and Sharma, Efficiency of Miswak as an oral hygiene aid among the

madrasa going children of Nuh – A socioeconomically disadvantaged district of India.; Saudi J

Oral Sci., 9:27-31. (2022).

- S. Mohamed and J. Khan, Antioxidant capacity of chewing stick miswak Salvadora persica.

BMC Complement Altern. Med., 13:40. (2013).

- M. Al-Ahmari, A. Alzahrani, F. Al-Qatarneh, M. Al Moaleem, M. Shariff, S. Alqahtani, A.

Porwal, F. Al-Sanabani, and T. AlDhelai, Effect of Miswak Derivatives on Color Changes and

Mechanical Properties of Polymer-Based Computer-Aided Design and Computer-Aided

Manufactured (CAD/CAM) Dental Ceramic Materials.; Med Sci Monit., 28: e936892 .(2022).

- M. Al Bratty, H. Makeen, H. Alhazmi, S. Syame, A. Abdalla, H. Homeida, S. Sultana, W.

Ahsan, and A. Khalid, Phytochemical, Cytotoxic, and Antimicrobial Evaluation of the Fruits of

Miswak Plant, Salvadora persica L. J. Chem., 4521951, 11.( 2020).

- H. Ramli, T. Mohd-Dom, and S. Shahida Mohd-Said, Clinical benefts and adverse efects

of siwak (S. persica) use on periodontal health: a scoping review of literature. BMC Oral

Health., 21, 618. ( 2021).

- M.Z. Aumeeruddy, G. Zengin, and M.F. Mahomoodally, A review of the traditional and

modern uses of Salvadora persica L. (Miswak): Toothbrush tree of Prophet Muhammad.; J.

Ethnopharmacol. 213: 409–444. (2018).

- M. Toutou, A. Soliman, M. Elokaby, M. Abdel-Rahim, A. Abouelwafa, and A. Yones,.,

The potential antimicrobial effects of dietary supplementation with Arak, Salvadora persica, on

growth, health status, and pathogenic bacterial loads in Nile tilapia, Oreochromis niloticus

fingerlings. Egypt. J. Aquat. Res. 45 :251–257. (2019).

- H, Sabbagh, K, AlGhamdi, H, Mujalled, and S. Bagher, , The effect of brushing with

Salvadora persica (miswak) sticks on salivary Streptococcus mutans and plaque levels in

children: a clinical trial. BMC Complement Altern Med.; 20:53. (2020).

- M.A. Farag, S. Fahmy, M.A. Choucry, M.O. Wahdan, and M.F. Elsebai, Metabolites

profiling reveals for antimicrobial compositional differences and action mechanism in the

toothbrushing stick "miswak" Salvadora persica. J. Pharm. Biomed. Anal.; 133: 32-40. (2017).

- S.I. Rabbani, Ameliorative Effect of Salvadora persica (Miswak) on Cigarette Smoke

Induced Anxiety and Depression in Rats., Int. J. Pharm. Investig. 10(1): 32-36 . (2020).

-M. Wassel, and M. Khattab, Antibacterial activity against Streptococcus mutans and

inhibition of bacterial induced enamel demineralization of propolis, miswak, and chitosan

nanoparticles based dental varnishes. J. Adv. Res., 8, 387–392. (2017).

- H. Pervaiz, S. Ahmed, F. Khalid, S. Riaz, S. Shabbir, and A. Haseeb, Pakistan J. Medical

Health Sci., Comparison of the Anti-Plaque Effect of Miswak (Salvadora Persica) and Dandasa

(Juglan Regia) on gingival health in a Prospective Cohort Study.. ; 16(11). (2022).

- S. Khunkar, I. Hariri, E. Alsayed, A. Linjawi, S. Khunkar, S. Islam, T. Bakhsh, and S.

Nakashima, Inhibitory effect of Salvadora persica extract (Miswak) on collagen degradation in

demineralized dentin: In vitro study. J Dent Sci. ; 16(1):208-213. (2021).

- N.M. Abbas, Y.M. El Imam, and M.A. Abdelmageed, The Phytochemical Analysis Of The

Ethanolic Extract Of Sudanese Aerva Javanica (Burm.F.) Juss. Ex J.A. Schultes. World J.

Pharm. Res. ; 4(06). (2015).

- F.S. Sabah, H.S. Al-Atbi and E.A. Mukhaiti, Flavonoids And Alkaloids Extracted From

marodphali (Helicteresisora) And Their Using Role As Anti-Bacterial, AntiFungal And Their

Effectiveness As Antioxidants. Nat. Vol. Essent. Oil.; 8(4): 4681-4691(2021).

- N. Asghar, Z. Mushtaq, M.U. Arshad, M. Imran, R.S. Ahmad, and S.M. Hussain,

Phytochemical composition, antilipidemic and antihypercholestrolemic perspectives of Bael leaf

extracts. Lipids Health Dis. ; 17:68 (2018).

- H. Balto, I. Al-Sanie, S. Al-Beshri, and A. Aldrees, Effectiveness of Salvadora persica

extracts against common oral pathogens., Saudi Dent J.,,29(1):1–6. (2017).

- H. Al-Atbi, B. Al-Salami, and I. Al-Assadi, New azo-azomethine derivative of

sulfanilamide :Synthesis, Characterization, Spectroscopic, Antimicrobial and Antioxidant

activity study. IOP Conf. Series: Journal of Physics: Conf. Series. 2019; 1294,052033.(2019).

- F. Xiao, T. Xu, B. Lu, and R. Liu, Guidelines for antioxidant assays for food components.

Food. Front. ; 1:60–69. (2020).

- R.J. Nijveldt, E.V. Nood, D.E. Hoorn, P.G. Boelens, K.V. Norren and P.A. Leeuwen,

Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin.

Nutr. 74: 418–25. (2001).

- S. Banjarnahor, and A. Artanti, Antioxidant properties of flavonoids. Med. J. Indones.,

,(4) 23(2014).

- J. Gan, Y. Feng, Z. He, X. Li, and H. Zhang, Correlations between Antioxidant Activity and

Alkaloids and Phenols of Maca (Lepidium meyenii). J. Food Qual., Article ID 3185945 (2017).

- T.P. Yin, L. Cai, Y. Xing, J. Yu, X.J. Li, R.F. Mei, and Z.T. Ding, Alkaloids with

antioxidant activities from Aconitum handelianum., J. Asian Nat. Prod. Res.;18(6):603-10

(2016).

- I.A. Asih, I.B. Manuaba, K. Berata and B.K. Satriyasa, The Flavonoid Glycosides

Antioxidant From Terong Belanda (Solanum betaceum ), Biomed. Pharmacol. J., 11(4), 2135-

(2018).

- C. Rha, H. Jeong , S. Park, S. Lee, Y. Jung and D. Kim, Antioxidative, Anti-Inflammatory,

and Anticancer Effects of Purified Flavonol Glycosides and Aglycones in Green Tea.

Antioxidants., 8, 278; (2019)

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Published

2023-12-24

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