Conductometric Titration Method for the Determination Chlorpheniramine Maleate (CPM)in Pure and Pharmaceutical
DOI:
https://doi.org/10.32792/jmed.2025.29.11Keywords:
Conductometric titration, Chlorpheniramine maleate, Sodium tetraphenylborate (TPB(, Sodium hydroxideAbstract
A straightforward, accurate, quick, and inexpensive conductometricapproach has been described for determining chlorpheniramine maleate
(CPM) in pure form and in pharmaceutical formulations utilizing sodium
hydroxide, Silver Nitrate, and sodium tetraphenylborate (TPB). The
proposed method is based on the cation association of the drug with the
anion of the base used . Sodium hydroxide was used instead of TPB and
AgNO3 because it is a strong, effective, readily available, inexpensive
base that dissolves easily in water. The solution's conductivity was
measured in relation to the titrant volume. The substance under study
was tested in double-distilled water at concentrations between 0.39 and
1.9 mg. The effect of different temperatures (20-55°C) on the endpoint
was evaluated. The obtained results demonstrated positive recovery rates
(94%-102%) with a relative standard deviation less than 1.0% for
chlorpheniramine maleate.These medications' pharmaceutical
compositions were successfully analyzed using the suggested methods.
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