Evaluating diabetic nephropathy Severity by the 8-OHDG, AGEs and oxidative stress Biomarkers
DOI:
https://doi.org/10.32792/jmed.2025.29.12Keywords:
Diabetic nephropathy, 8-OHDG, AGEsAbstract
Back groundEnd-stage kidney disease (ESKD) is most commonly caused by diabetic kidney
disease (DKD) in affluent nations, including the US. It is a microvascular
complication that can arise in people with type 1 diabetes (T1DM) or type 2
diabetes (T2DM).Aims of the study: Understanding the connection between
vitamin D and Cytokine levels in diabetic nephropathy patients.Result : The
study's 90 participants (40 women and 50 men) showed a wide variety of ages,
with most of them being between 45 and 82. The study compared the
relationship between diabetic nephropathy and several kidney function
parameters in males and females, showing differences in the levels 8-OHDG,
AGEs and oxidative stress Biomarkers. The comparison of oxidative stress
biomarker (MDA, 8OHDG, AOPP, HNE4 and AGE) between patient and
control groups has been carried out.
Conclusions: It has been observed that the values of kidney efficiency
parameters are affected in diabetic patients after a number of years, and as a
result this leads to an increase in the values of these parameters, which
ultimately leads to kidney damage or severe damage, which makes the people
concerned need to undergo dialysis or even a kidney transplant, or in late cases
it may lead to death.
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Copyright (c) 2025 Lina A. Naser, Bushra A. M. Abdul Azeez, Ali Jameel Hameed
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