Assessment a Novel Iron Status Biomarker (Hepcidin) among Patients with Psoriasis

Abstract

Background: Psoriasis is a skin disease caused by an overactive immune system, affecting up
to 3% of the population. It is characterized by chronic inflammation and excessive growth of skin
cells due to interactions between immune cells and skin cells. Recently, researchers have observed
connections between psoriasis and other systemic diseases, suggesting that skin inflammation may
be related to inflammation throughout the body. Hepcidin is a peptide hormone transcription in
the hepatocytes, is a significant iron homeostasis regulator that was just recently identified. The
interaction between positive and negative stimulation is crucial in defining the net levels of
Hepcidin, even though the iron store and inflammatory regulation activate Hepcidin and hypoxia,
anemia, excessive iron load, and enhanced erythropoiesis all adversely control Hepcidin
expression.
Methods : In a case-control study, 120 psoriasis patients and 120 seemingly healthy controls
matched for age and sex were included., ages ranging from 18-60 years, who attended Al-Nasiriya
Teaching Hospital specialized dermatology and venereology consultant from December 2023 to
June 2024. five milliliters of blood were drawn via venin puncture. According to the
manufacturer's instructions, Hepcidin in serum will be measured using a sandwich enzyme-linked
immunosorbent assay (ELISA) kit (Sunlong, China, REF SL0868Hu). and serum hs CRP using
routine standard method.
Results :The results indicate that the level of serum Hepcidin significantly decreased (P<0.05).),
and higher significantly increase in hs-CRP (P<0.001) in psoriatic patients as compared to the
control subjects, also indicate that the mean hsCRP value is statistically significantly higher
(P<0.001), in patients with moderate to severe psoriasis than in patients with mild psoriasis.
Conclusions Psoriasis was associated with significantly decreased serum hepcidin levels
compared to control subjects, suggesting that Hepcidin may be involved in the disturbed iron status
reflecting the influence of psoriasis etiologies on Hepcidin expression. And also proposed that
serum hsCRP was an effective psoriasis severity marker that might be applied to monitor the
disease's progression and, used together with PASI, as a worldwide measure of disease severity.