Predictors of Helicobacter pylori infectivity, Using Stool Antigen Test in Al- Qurna

Authors

  • Rafid AJ Mohammed Lecturer, Department of surgery College of Medicine, University of Basrah Basrah, Iraq
  • Talib Kadhim Aggar Lecturer, Department of Medicine College of Medicine, University of Basrah Basrah, Iraq
  • Abddulhameed Majeed Head of Department of Medicine Alsadr teaching hospital, Basrah, Iraq

Keywords:

H pylori, predictors of infectivity, Al Qurna

Abstract

Aim: To identify   predictors of Helicobacter pylori (H pylori) infectivity, Using stool antigen   test with its correlations to epigastric abdominal pain and other gastrointestinal symptoms. Patients &methods: Patients   from Al Qurna presented to private clinic with epigastric abdominal pain each of them has been screened for H pylori via stool antigen test, after evaluations of other causes of abdominal pain. Data analysis was carried out using SPSS version-15              Results:  a   total   of 254     patients   142 (55.9%) were    males   and 112 (44.1%) were    females were studied.  H pylori   stool antigen was positive in 69 (27.2 %) and negative in 185 (72.8%) of the   studied patients. Gastrointestinal symptoms that were observed included weight loss, loss of appetite (3.6%), heart burn (60.6%), vomiting (28.3%), diarrhea (7.1%), constipation (15.4%) and abdomen distension (24%). In 59.3% of the H. pylori antigen positive cases, the duration   of epigastric pain was of >two weeks. Conclusions:   logistic regression analysis indicated that epigastric abdominal   pain of > two weeks and loss of appetite were two significant predictors of H. Pylori infection.

References

Warren JR, Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; 1: 1273-1275.

Walker B, Colledge N, Ralston S, Penman I, Penman I, Lees C. Alimentary tract and pancreatic disease in: Penman I, Lee C, Davidson principles & practice of internal medicine Elsevier 22ed, 2014, p851, 872.

Kupers E, Blaser M. Acid peptic disease in: Goldman L, Schafer A: Goldman's Cecil Textbook of Medicine 24th ed. 2012. P 887,513-514.

Hussen B, Qader S, Ahmed H, Ahmed S. The Prevalence of H pylori among University Students in Iraq. Indian Journal of Science and Technology 36340-37557-1-PB.

Parsonnet J, Shmuely H, Haggerty T. fecal and oral shedding of Helicobacter pylori from Healthy infected adults. JAMA 1999; 282(23):2240-2245.

Khan M, Ghazi H. Helicobacter pylori infection in asymptomatic subjects in Makkah, Saudi Arabia. Journal of Pakistan Medical Association 2007; 57(3): 114-117.

Özaydın A, the geographic variance of Helicobacter pylori. EMJ Gastroenterol. 2014; 3: 94-102.

Shimoyama T. Stool antigen tests for the management of Helicobacter pylori infection. World J Gastroenterol. 2013; 19(45): 8188–8191.

Walsh T, Attiah E, Long D, Kasper D, Jamesson J, Fauci A. Hauser S Et al. Eating Disorders in: Harrison's principles of internal medicine. McGraw Hill Medical. 18th Edition 2012. P. 636.

Talley NJ, O' Connor S. Clinical Examination. A systematic guide to physical diagnosis .6th edition Elsevier Australia ., 2012.P 146

Lennon A, Goggins M. Disorders of the small and large intestine. The Johns Hopkins Internal Medicine Board Review. Johns Hopkins, 4thed 2012, p.213, 218.

Lee CS, Kim D, jung CW, Park jy. Prevalence of Helicobacter pylori in Bangladesh: Rapid urease test. The ORION Medical Journal 2003;16: 104-105

Rowland M, Daly S, Vaughan M, Higgins A, Bourke B, Drumm B. Age specific for Helicobacter pylori. Gastroenterology 2006 130(1); 65.

Chen S, Ying L, Kong M, Zhang Y, Li Y. Chen S et al. The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis Hindawi PublishingCorporation. Gastroenterology Research and Practice 2013; (2013) 3.

Sitas F, Forman D, Yarnell J, Burr M, Elwood P, Pedley S, Marks K. Helicobacter pylori in relation to age and social class in a population of Welsh men. Gut 1991;32: 25-28.

Bode G, Rothenbacher D, Brenner H. Helicobacter pylori colonization and diarrhoeal illness: results of a population-based cross-sectional study in adults. European Journal of Epidemiology 2002, 17:823-827.

Adlekha s, Chandha T, Krishnan P, Sumangala B. Prevalence of Helicobacter Pylori Infection Among Patients Undergoing Upper Gastrointestinal Endoscopy in a Medical College Hospital in Kerala, India Ann Med Health Sci Res. 2013;3(4): 559–563.

e Martel C, Parsonnet J. Helicobacter pylori and gender: a meta-analysis of population –based prevalence surveys. Dig Dis Sci 2006;15(12) :2292-301.

Moshkowitz M, Horowitz N, Beit-Or A, Halpern Z, Santo E; Gender-associated differences in urea breath test for Helicobacter pylori infection referrals and results among dyspeptic patients. World J Gastrointest Pathophysiol 2012; 15(3):80-88.

Ohtani M, Garcia A, Rogers A, Ge Z, Taylor N, Xu S. Protective role of17 betas –estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice. Carcinogenesis 2007; 28(12):2597-2604.

Laine L, Sugg J. Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies. Am J Gastroenterol 2002; 97: 2992-7.

Falk GW. The possible role of Helicobacter pylori in GERD. Semin Gastrointest Dis. 2001 12(3):186-95.

Cho I, Blaser MJ, Francois F, Mathew JP, Ye XY, Goldberg JD, Bini EJ. Helicobacter pylori and Overweight Status in the United States: Data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2005; 162(6):579-84.

Nwokolo CU, Freshwater DA, O'Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut 2003; 52(5):637-640.

Yakoob J, Abbas Z, Naz S, Islam M, Jafri W. Virulence markers of Helicobacter pylori in patients with diarrhoea-dominant irritable bowel syndrome. Br J Biomed Sci. 2012; 69(1):6-10.

Brooks GF, Carroll KC, Butel JS, Morse SA, Mietzner TA. Jawetz, Melnick, and Adelberg’s Medical Microbiology Twenty-Sixth Edition.2013. Chapter 17 Pp 261-262.

Pearce M, Campbell D, Mann K, Parker L, Thomas J. Deprivation, timing of preschool infections and H. pylori seropositivity at age 49-51 years: the Newcastle thousand families birth cohort. BMC Infectious Diseases, 2013; 13:422.

Salih BA. Helicobacter pylori Infection in Developing Countries: The Burden for How Long? The Saudi Journal of Gastroenterology 2009; 15:.201-207.

29. Malaty H. Epidemiology of Helicobacter pylori infection Best Pract Rest Clin Gasrtoenterolo .2007; 21 (2): 205–214.

Katelaris P, Seow F, Lin B , Napoli j, Ngu M , and Jones D: Effect of age, Helicobacter pylori infection, and gastritis with atrophy on serum gastrin and gastric acid secretion in healthy men. Gut.1993; 34(8):1032-1037.

Francis D gastritis in: Hauser S, Pardi D, Poterucha J. The Mayo Clinic Gastroenterology and Hepatology Board Review myoclinic scientefic press 2008 p32, 71

Vo H, Goli S, Gill R, Anderson V, Stefanov D, Xu J: Inverse relation between Helicobacter pylori Colonization and obesity in cohort of inner city children, Helicobacter. 2015; 20(1):64-8.

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Published

2020-10-08

Issue

Vol. 11 No. 1 (2016)

Section

Articles