Value of d-dimer test in diabetic patients as predictive marker for coronary artery disease
Abstract
D dimer is fibrin degradation product. When blood clot is degraded by fibrinolysis, natural mechanism in the body occurs when plasminogen is activated to plasmin by fibrin. D dimer level normally in a range around 250mg per ml. The test tends to be positive in deep venous thrombosis, pulmonary embolism, aortic dissection and post-operative state. Here in this study we try to investigate the level of d dimer in the diabetic patient in comparison to non-diabetic subject. There was significant increase in the level of d dimer in the diabetic group. The other arm of the study is to compare the diabetic group with no clinical evidence of coronary artery disease and diabetics with documented IHD. The level was doubled and this raises the equation to initiate anti coagulation therapy early in diabetics.References
- Blomback B; hessl B; Hogged Tow step fibrinogen fibrin in blood coagulation.
- Fowler WE; Grickson HP'Hantgan RR; Mc. Donagh J; Hermans J Cross linked fibrinogen d-dimers demonstrate features of molecular packing in fibrin fibers.
- Green berg CS; Miralgia CC; Rickies FR; shuman MA Cleavage of blood coagulation factor x111 and fibrinogen by thrombin in vitro dotting.
- Medved L; nieuwenhuizen W Molecular mechanism of intiation of fibrinolysis by fibrin.
- Marden VT; Zareba W; Horan JT; Moss AJ; Kanonse J JAutomated latex agglutination and elisa testing yield equivalent d-dimer result in patient with recent myocardial infarction.
- Lowe GD Fibrin d-dimer and cardiovascular disease.
- Ems MT; Bunce IH; Bundesen PG Measurement of cross linked degredation product.
- Cichingers d-dimer testing in pregnancy.
- Chan W.S; Chunilal; S; Lee A Red blood cell agglutination d-dimer to exclude DVT in pregnancy
