Correlation Study Between C-Reactive Protein, Procalcitonin with Hematological Parameters Of Children with Pyrexia of Unknown Origin (PUO) in Karbala Pediatric Teaching Hospital

  • Ali Abdulrazzaq Karbala Pediatric Teaching Hospital / Karbala Health Directorate
  • Ahmed Salim Hadi Al-Khafaji Karbala Pediatric Teaching Hospital / Karbala Health Directorate
  • Nihad Khalawe Tektook Middle Technical University / College of Medical &Health Technology, Medical laboratory techniques dep. / Iraq
Keywords: Fever, PCR, CRP, PUO, Children

Abstract

A case control hospital based selective study was done on 100 children with PUO who admitted to the Karbala Pediatric Teaching Hospital in Karbala city, during the period from 1st of March 2018 to the last of March 2019 aged from 2 months-5 years. A comparable group of similar number of cases of apparently healthy children was taken as a control group. This study aimed to evaluate the diagnostic value of CRP and PCT pyrogenic of unknown origin (PUO) in relation to some hematological parameters. The study included the collection of 3 ml of blood from each patient and control for assessment of PCT and CRP by immunofluorescence and hematological parameters by general auto-analyzer hematology. This case control study included 100 children with PUO (60 males and 40 females), their age range was 3-48 months (mean: 17.12±8.2 month), the study also included 100 healthy children (as control group) with the same characteristics of the patient. The study revealed that the highest mean level of PCT was recorded among children with PUO (17.36 ng/ml) and the lowest level mean level was found in healthy children (3.56 ng/ml). The study also exposed that the highest mean level of CRP was recorded among children with PUO (22.6 ng/ml) and the lowest level mean level was found in healthy children (2.11 ng/ml). The study showed that WBCs, neutrophils and lymphocytes counts were elevated significantly among children with PUO as compared with healthy children. The study revealed a significant positive correlation between PCT and CRP among children with PUO (r: 0.84, P<0.001), and a significant positive correlation of  PCT and CRP with each of WBCs, neutrophils and lymphocytes counts among children with PUO. It was concluded that there a significant positive correlation between PCT and CRP and significant positive correlation of  PCT and CRP with each of WBCs, neutrophils and lymphocytes counts among children  with PUO

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Published
2021-02-26
Section
Articles