PREVALENCE OF URINARY TRACT CALCULI AND THE QUALITATIVE ANALYSIS OF THEIR CHEMICAL COMPOSITION OF PATIENTS WITH UROLITHIASIS IN THI - QAR GOVERNORATE / IRAQ
Keywords:
Urolithiasis, The chemical composition of urinary tract calculiAbstract
Objectives: The present study was conducted to evaluate the prevalence of urolithiasis in relation to patients six, age, and anatomical distribution of stones and to assess the chemical composition of urinary stones qualitatively to identify common type of urinary stone which prevalence in Nasiriyah city and how can provide the recurrence of stone formation if possible. Methods: Forty-four calculi obtained from 29 males and 15 females afflicted with Urolithiasis and admitted at Al Hussein Teaching Hospital, Thi-Qar governorate, Nasiriyah city, Iraq, from July 2010 to September 2011. Their ages ranged from 30 to 60 year. All samples analyzed qualitatively for ammonia, magnesium, phosphate, magnesium ammonium phosphate, carbonate, calcium salts (oxalate and non-oxalate), uric acid, xanthine, and cystine by adopting standard methods. Results: The study results showed that, the prevalence of stones was more in males (65.91%) than females (34.09%) with male to female ratio of 1.93:1 and the high occurrence in patients aged from 30 to 50 years. The anatomical distribution of urinary stones showed high percent in kidneys 52.27 % (23 patients) and bladder 47.73 % (21 patients), but it is absent in ureters and urethral (0.00 % ). All the stones were of mixed type, of these stones contained 42 (95.46 %) calcium salts (oxalate and non oxalate), uric acid, and ammonium ion, 41(93.18 %) phosphate, 33 (75.00%) magnesium and magnesium ammonium phosphate (MAP), 29 (65.91%) carbonate, 26 (50.00) xanthine, and 7 (15.91 % ) cystine. In addition, there are no differences in the chemical combustion between kidneys and bladder stones. Conclusion: Urolithiasis in Nasiriyah is a problem with high frequency in men than women and usually described as more frequent in age ranged 30 to 50 year and in kidneys and bladder than ureters and urethral. The majority of urinary stones types had a mixed type in which calcium salts (oxalate and non-oxalate), uric acid, ammonia phosphate and struvite were the predominant constituents related that both the metabolic disturbances and bacterial infection causes, which have the same majority and effect in the stone formation.References
Adisorn A, Choosak P. : Urinary tract calculi in southern Thailand. Med Assoc Thai. 2005: 88(1): 80-85.
Balaji K.C, Menon M. : Mechanism of stone formation. In: Resnick MI: Urolithiasis. Urol. Clin. North. Am. 1997 : 24(1):1-10.
Parmar M.S. Kidney stones. J Urol. 2004: 328(7453): 1420-1424.
http: //www. mission pharacal. com/ urocitk / kidney stones.2005.
Herring L C. : Studies on urinary calculi. J Urol 1962; 88: 545-562.
Gowenlock A. H, McMurray J.R., McLauchl¬lan D.M. : Varley’s practical clinical biochemistry, 6th ed. London, Heinemann Medical Books, 1988:756–61.¬
Rizvi S.A. Naqvi A. A, Hussain Z, Hussain M, Zafar M.N, Sultan S, and et al: Management of pediatric urolithiasis in Pakistan: Experience with 1,44o children. The Journal of Urology 2003: 169: 634-37.
Frank M, De Vries A. :Prevention of Urolithiasis. Education to adequate fluid intake in a new town situated in Judean Dessert Mountains. Arch. Environmental Health 1966; 13: 625.
Welshman S.G, McGeown M.G. : The relationship of the urinary cations, calcium, magnesium, sodium, and potassium in patients with renal calculi. Br. J. Urol. 1975; 47: 237-242.
Monu J.U. : Pattern of Urolithiasis in Benin City, Nigeria. J Natl Med Assoc 1989; 81: 695-698.
Nayar D, Kapil U, Dogra P.N. : Risk factors in Urolithiasis. The Indian Practitioner 1997; 50: 209-14.
Mbonu O, Attah C, Ikeakor I. : Urolithiasis in an African population. Int Urol Nephrol 1984: 16: 291-296.
Pendse A.K and Singh PP: The etiology of Urolithiasis in Udaipur (Western part of India). Urol Res 1986: 14: 59-62.
Colella J, Kochis E, Gall B, et al.: Urolithiasis/Nephrolithiasis: What's it all about? Urol. Nurs. 2005; 25 (6): 427-448.
Robertson W.G, Peacock M, Marshall D.H. : The prevalence of urinary stone disease in practicing vegetarians. Fortschritte der Urologie und Nephrologie, 1981; 17:6–14.
Robertson W.G., Peacock M., Heyburn P.J. : The risk of calcium stone formation in relation to affluence and dietary anim¬al protein. In: Brockis JG, Finlayson B, eds. Urinary calculus. Littleton, MA: PSG Publishing Co., 1981; 3-12.
Finkielstein V.A, Goldfarb D.S. Strategies for preventing calcium oxalate stones Canadian Med Assoc J, 2006; 174:1407-9.
Massey L.K. :Dietary influences on urinary oxalate and risk of kidney stones. Front Biosci. 2003; 8: 584–94.
Masai M.H, Ito H, Kotake T. : Effect of dietary intake on urinary oxalate excretion in calcium renal stone formers. Brit J Urol Int’l .1995; 76: 692–6.
Singh P.P, Barjatiya M.K, Dhing S, et al. :Evidence suggesting that high intake of fluoride provokes nephrolithiasis in tribal populations. Urol Res .2001; 29: 238–44.
Kirk Claudia A., Gerald V. Ling, Charles E. Franti, Janet M. Scarlett.: Evaluation of Factors Associated With Development of Calcium Oxalate Urolithiasis in Cats. Journal American Veterinary Medical Association . 1995. 207: 1429-1434.
Anatol TI, Pinto Pereira L, Matthew J, Sawh L. The relationship of magnesium intake to serum and urinary calcium and magnesium levels in Trinidadian stone formers. Int J Urol. 2005 Mar;12(3):244-9.
Vernon M. Pais Jr, Gregory Lowe, Costas D. Lallas, Glenn M. Preminger and Dean G. Assimos: Xanthine urolithiasis ,Urology. 2006, 67(5) May,1084.e9-1084.e11.
Scott D and Martin I. Cystine calculi: Diagnosis and management. Urol. Clin. North. Am. 1997; 24(1): 163-171.
Robertson W.J, Peacock M, Heyburn P.J. : Risk factors in calcium stone disease of the urinary tract. Br J Urol .1978; 50: 449-454.
Qaader D.S, Yousif S.Y, Mahdi L.K, : prevalence and etiology of urinary stones in hospitalzed patients in Baghdad, Eastern Mediterranean Health Journal. 2006, 12: 6: 853-861.
Khan A.S, Rai M.E, Gandapur Gandapur, Pervaiz A, Shah A.H, Hussain A.A, Siddiq M. : Epidemiological risk factors and composition of urinary stones in Riyadh Saudi Arabia. J Ayub Med Coll Abbottabad. 2004;16:56–8.
35. Hammad FT, Kaya M, Kazim E. : Bladder calculi: did the clinical picture change? Urology. 2006;67:1154–8.
Pushpa Durgawale, Anup Hendre, Sangita Patil, Ajit Sontakke: Chemical analysis of stones and its significance in urolithiasis. Biomedical Research ,2010; 21 (3): 305-210.
Hossain R.Z, Ogawa Y, Hokama S, Morozumi M, Hatano T. Urolithiasis in Okinawa, Japan: a relatively high prevalence of uric acid stones. Int J Urol. 2003;10:411–5.
Olapade-Olaopa E.O, Agunloye A, Ogunlana D.I, Owoaje ET, Marinho T. Chronic dehydration and symptomatic upper urinary tract stones in young adults in Ibadan, Nigeria. West Afr J Med. 2004;23:146–50.
Tanthanuch M, Apiwatgaroon A, Pripatnanont C. Urinary tract calculi in southern Thailand. J Med Assoc Thai. 2005; 88:80–5.