• Abdulameer Abudi Mohammed Lecturer in Faculty of Medicine, Kufa University, Radiologist in Al-Yarmouk Teaching Hospital, Baghdad, Iraq


Iodinated LOCM, penicillin allergy, CT scan


Background: Intravenous (I.V.)  low osmolar contrast media (LOCM) is commonly used during computerized tomography CT scan examinations, especially in diagnosis and staging of tumours, trauma and abdominal examinations. Many radiologists are relactant to do enhanced examination if patients had history of penicillin allergy. This study aims to evaluate the incidence of LOCM-related side-effects in patients with penicillin allergy compared to patients without penicillin allergy. Methods and patients: Prospective study of 357 patients examined in CT scan unit in Al-Yarmouk teaching hospital, 44 of them had history of penicillin allergy, all given i.v. contrast medium (LOCM), and the prevalence of LOCM related side effects calculated for both groups. Results:  The prevalence of contrast medium related side effect was 0.64% in patients without history of penicillin allergy, while of the 44 patients with penicillin allergy, no side effects has been encountered. Conclusion: No significant increase in LOCM related side effect was seen in patients with penicillin allergy.


- A. Adam, A. K. Dixon, R. G. Gainger, D. J. Allison. Diagnostic radiology text book of medical imaging, Churchill Livingstone 2008, Vol. 1, 2:27, 34.

- Osborne, E. D. Sutherland, C.G., Scholl, A.J., et al. Reontegnography of the urinary tract during excretion of sodium iodide. 1923, JAMA 80, 368-373.

- P. Dawson, W. Clauss. Contrast media in practice questions and answers. Springer-Verlag Berlin Heidelberg 1999.chap 1 P 1,43.

- Swick M Darstellung Der Niere und Harnwege in Roentgenbild durch intravenose Einberingung eines neuen Kontraststoffes: des Uroselectans. 1929, Klin Wochenscher 8: 2087-2089.

- Christopher H. Hunt; Robert P. Hartman; Gina K. Hesley, Frequency and Severity of Adverse Effects of Iodinated and Gadolinium Contrast Materials: Retrospective Review of 456,930 Doses, Am J Roentgenol. 2009;193(4):1124-1127.

- John R. Haaga et al, CT and MRI of the whole body, Mosby 2009. Vol. 2, 39:1807.

- Lalli A F 1980 contrast media reactions:data analysis and hypothesis.Radiology 134: 1-12

- Sidhu P S, Dawson P 1999 adverse reaction to contrast media. Isis medical media, oxford, ch. 9: pp 99-119.

- Dawson P, Cosgrove D O, Grainger R G 1999 textbook of contrast media, ch. 11, ch. 15 Isis medical media, oxford.

- American College of radiology manual on iodinated contrast media version 7, 2010, ACR, Chicago. P 17.

- Dillman JR, Strouse PJ, Ellis JH, Cohan RH, Jan SC. Incidence and severity of acute allergic-like reactions to i.v. nonionic iodinated contrast material in children. AJR Am J Roentgenol 2007; 188:1643–1647.

- Schmitt KM, Behrends B, Claus W, Kaufmann J, Lehnert J (1986) Iohexol in der Ausscheidungsurographie. Ergebnisse des Drug-monitoring. Fortscher Med 7:153-156

- Katayama H, Yamaguchi K, Kozuka T et al. (1990) adverse reactions to ionic and non-ionic contrast media. A report from Japanese committee on the safety of contrast media. Radiol 11:52-66

- Palmer FJ (1989) the royal Australian college of radiologists (RACR) survey of reactions to intravenous ionic and non-ionic media. In Enge I, Edgren J (eds) patients safety and adverse events in contrast medium examination. Elsevier, Amstrdam, pp 137-141

- Cochran ST, Bomyea K, Sayre JW. Trends in adverse events after IV administration of contrast media. AJR Am J Roentgenol 2001; 176:1385–1388.

- Wolfgang Dahnert. radiology review manual.Lippincott Williams and Wilkins, 2007. Vol. 2: 1132.

- Wang CL, Cohan RH, Ellis JH, Caoili EM, Wang G, Francis IR. Frequency, outcome, and appropriateness of treatment of nonionic iodinated contrast media reactions. AJR Am J Roentgenol 2008; 191:409–415.