REGULAR PHYSICAL ACTIVITY: CORRELATION WITH CONVENTIONAL CARDIOVASCULAR RISK FACTORS

Authors

  • Salman K. Ajlan Department of Biochemistry, College of Medicine, University of Basrah, Basrah, IRAQ

Keywords:

ٌRegular physical activity, conventional cardiovascular risk factors cardiovascular disease risk

Abstract

Objective: To correlate  regular physical activity (RPA) with conventional cardiovascular (CV) risk factors. Methods:   In this study, 116 young adult males , 56 physically active and 60 physically inactive (sedentary),  were included.  Measurement of  body mass index  (BMI), basal energy expenditure (BEE) systolic  and diastolic blood pressure  (SBP, DBP ) and serum concentrations of fasting blood glucose (FBG), total cholesterol  (TC) , triglyceride (TG) , low density lipoprotein-cholesterol (LDL-C), and   high density lipoprotein-cholesterol  (HDL-C) were performed. Results: Correlation and regression analysis revealed significant negative correlation of  RPA with BMI  (r: -0.414, P: 0.000), BEE (r: - 0.388, P: 0.000) SBP  (r: -0.418, P: 0.000), DBP  (r: -0.439, P: 0.000) ), FBG (r: -0.425, P: 0.000), TC  (r  -0.291, P: 0.002) ,  TG (r: -0.408, P: 0.000)  , LDL-C (r: -0.305, P: 0.001), and  significant  positive correlation with  HDL-C  ( r :+0.430, P: 0.000). Conclusion:  The study  demonstrated  a strong inverse relationship between RPA and CVD risk. Therefore, practicing moderate RPA is  crucial to maintain healthy life and improve cardiovascular fitness, and this considerably reduces  the future risk of  CVD and its adverse clinical consequences.

References

Paffenbarger RS Jr, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality and longevity of College Alumni. N Engl J Med 1986; 314: 605-613.

Mora S, Cook N, Buring JE, et al. Physical activity and reduced risk of cardiovascular events. Circulation 2007; 116: 2110-2118.

Lakka T, Venalainen JM, Pauramaa R, et al. Relation of lesiure- time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. N Engl J Med 1994; 330: 1549-1554.

Dunn AL, Marcus BH, Kampert JB, et al. Comparison of lifestyle and structured exercise interventions to increase physical activity and cardiorespiratory fitness. JAMA 1999; 281: 327-334.

Rodriguez BL, Curb JD, Burchfiel CM, et al. Physical activity and 23-year incidence of coronary heart disease morbidity and mortality among middle-aged men. The Honolulu Heart Program. Circulation 1994; 89: 2540-2544.

Stefanick ML, Mackey S, Sheehan M, et al. Effects of diet and exercise in men and postmenopausal women with low levels of HDL-Cholesterol and high levels of LDL-Cholesterol. N Engl J Med 1998; 339: 12-20.

Seals DR, Desouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. . J Appl Physiol. 2008 ;105:1323-1332.

Poirier P, Despres JP. Exercise in weight management of obesity. Cardiol Clin 2001; 19: 459-470.

Carroll S, Dudfield M. What is the relationship between exercise and metabolic abnormalities? A review of the metabolic syndrome. Sport Med 2004; 34: 371-418.

Lakka TA, Bouchard C. Physical activity, obesity and cardiovascular diseases. Handb Exp Pharmacol 2005; 170: 137-163.

Lakka TA, Laaksonen DE. Physical activity in prevention and treatment of the metabolic syndrome. Appl Physiol Nutr Metab 2007; 32: 76-88.

National Institute of Health. Physical activity and cardiovascular health. JAMA 1996;276:241-246.

Camm AJ, Bunce N.Cardiovascular disease. In: Kumar P, Clark M, eds. Kumar & Clark linical Medicine.7th edn, Edinburgh: Saunders; 2009: 681-810.

Newby DE, Grubb NR, Bradbury A. Cardiovasculr disease. In: Colledge NR, Walker BR, Ralston SH, eds. Davidson’s Principles and Practice of Medicine. 21st edn, Edinburgh: Churchill Livingstone;2010: 521-640.

Powell KE, Blair SN. The public health burdens of sedentary living habits: theoretical but realistic estimates. Med Sci Sports Exerc 1994; 26: 851-856.

Blair SN, Kampert JB, Kohl HW, et al. Influences of cardiorespiratory fitness and other precursors of cardiovascular disease and all-cause mortality in men and women. JAMA 1996; 276: 205-210.

Mora S, Lee I, Buring JE, et al . Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 2006; 295:1412-1419.

Hamilton MT, Hamilton DG, Zderic TW. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 2007; 56: 2655-2667.

Prentice AM. The emerging epidemic of obesity in developing countries. Int J Epidemiol 2006 ;35:93-99.

Dandona P , Aljada A, Chaudhuri A , et al; Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005 ;111:1448-1454.

McGavock JM, Anderson TJ, Lewanczuk RZ. Sedentary lifestyle and antecedents of cardiovascular disease in young adults. Am J Hypertens. 2006 ;19:701-707.

Friedwald WT, Levy RI, Fredickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.

Veldee MS. Nutrition. In: Burits CA, Ashwood ER, eds. Tietz Textbook of Clinical Chemistry. 2nd edn, Philadelphia: W.B. Saunders Company, 1994: 1236-1274.

Zoeller RF. Physical activity: The role of physical activity and fitness in the prevention and management of type 2 diabetes mellitus . Am J Lifestyle Med 2007; 1: 344-350.

Gaillard TR, Sherman WM, Devor ST, et al. .Importance of aerobic fitness in cardiovascular risks in sedentary overweight and obese African-American women. Nurs Res. 2007;56:407-415.

Al-Hazzaa HM. Physical activity, fitness and fatness among Saudi children and adolescents. Implications for cardiovascular health. Saudi Med J 2002; 23: 144-150.

Andersen RE, Wadden TA, Barlett SJ, et al. Effects of lifestyle activity vs structured aerobic exercise in obese women. JAMA 1999; 281: 335-340.

. Hanlon P, Byres M, Walker BR, et al. Environmental and nutritional factors in disease. In: Colledge NR, Walker BR, Ralston SH, eds. Davidson’s Principles and Practice of Medicine. 21st edn, Edinburgh: Churchill Livingstone;2010: 95-129.

Grundy SM. Obesity. Metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2004; 89: 2595-2600.

Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause, 1990- 2020: Global burden of disease study. Lancet 1997; 349:1498-1504.

Schenck- Gustafsson K. Risk factors for cardiovascular disease in women: assessment and management. Eur Heart J 1996; 17 (Suppl D): 2-8.

Singh RB, Sharma VK, Gupta RK, et al. Nutritional modulators of lipoprotein metabolism in patients with risk mechanisms for coronary heart disease. Diet and moderate exercise trial. J Am Coll Nutr 1992; 11: 391-398.

Bistritzer T, Rosenzweig L, Barr J, et al. Lipid profile with paternal history of coronary heart disease before age 40. Arch Dis Child 1995; 73: 62-65.

Ajlan SK. Lipid profile and physical activity . JBMS 2004; 16: 186-191.

Despres JP,Pouliot MC, Moorjani S, et al. Loss of abdominal fat and metabolic response to exercise training in obese women. Am J Physiol 1991; 261: E159-167.

Singh RB, Rastogi SS, Ghosh S, et al. The diet and moderate exercise trial (DAMET): results after 24 weeks. Acta Cardiol 1992; 47: 543-557.

Raitakari OT, Porkka KV, Taimela S, et al. Effect of persistent physical activity and inactivity on coronary risk factors in children and young adults. The cardiovascular risk in young Finns Study. Am J Epidemiol 1994; 140-195-205.

Kriska A. Physical activity and the prevention of type 2 diabetes mellitus: how much for how long? Sport Med 2000; 29: 147-151.

Zhou M, Widmer RJ, Xie W, et al. Effects of exercise training on cellular mechanisms of endothelial nitric oxide synthase regulation in coronary arteriesafter chronic occlusion.. Am J Physiol Heart Circ Physiol. 2010 298:H1857-18.

Leung FP, Yung LM, Laher I, et al.Exercise, vascular wall and cardiovascular diseases: an update (Part 1). Sports Med. 2008;38:1009-1024.

Rush JW, Denniss SG, Graham DA. Vascular nitric oxide and oxidative stress: determinants of endothelial adaptations to cardiovascular disease and to physical activity. Can J Appl Physiol. 2005 ;30:442-474.

Raunamaa R, Vaisanen SB, Kuhanen R, et al. The Rsa I polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training – a controlled randomised clinical trial in men. Thromb Haemost 2000; 83: 803-806.

Gallistl S, Sudi KM, Cvirn G et al. Effects of short – term energy restriction and physical training on haemostatic risk factors for coronary heart disease in obese children and adolescents. Int J Obes Relat metab Disord 2001; 25: 529-532.

de Ferranti SD, Rifai N. C-reactive protein: a nontraditional serum marker of cardiovascular risk. Cardiovasc Pathol 2007 ;16:14-21..

Jousilahti P ,Salomaa V, Rasi V, et al.The association of C-reactive protein,serum amyloid A and fibrinogen with prevalent coronary heart disease:baseline findings of the PAIS project. Atherosclerosis 2001; 156: 451-456.

Yan RT, Fernandes V, Yan AT, et al. Fibrinogen and left ventricular myocardial systolic function: The Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J 2010 ;160: 479-486.

Hansson GK. Inflammatory mechanisms in atherosclerosis. J Thromb Haemost 2009;7 Suppl 1:328-331.

Lamon BD, Hajjar DP. Inflammation at the molecular interface of atherogenesis: an anthropological journey. Am J Pathol 2008 ;173:1253-1264.

Leon AS. Connett J. physical activity and 10 year mortality in the multiple risk factor intervention trial (MRFIT). Int J Epidemiol 1991; 20: 690-697.

MMWR. Morb Mortal Wkly Rep 1992; 41: 33-35.

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2021-05-22

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