VAGINAL PH AS A MARKER FOR VAGINITIS AND MENOPAUSAL STATUS

Authors

  • Zainab Hassan Al-Khafagy
  • Thura Jaafar Kadhum

Abstract

Vaginal PH was determined by universal indicator PH paper in 182 patients seen in Al-Zahara`a Hospital in Najaf city for routine speculum examination. None of the patients were pregnant. Measurements were made of serum levels of follicle – stimulating hormone and estradiol for 81 menopausal patients and vaginal culture were taken for all 182 patients. Vaginal PH was correlated with vaginal cultures and serum follicle – stimulating hormone and estradiol levels by use of statistical analysis. Vaginal PH was elevated in all premenopausal patients with documented bacterial pathogens. Serum estradiol levels showed an inverse and serum follicle – stimulating hormone levels a direct statistical correlation with vaginal PH in postmenopausal patients.       Aim of the study: The study had two objectives : (1) to confirm the elevations  of vaginal PH  in patients with bacterial pathogens in premenopausal women  and (2) to examine the relationship of serum FSH and estradiol levels to vaginal PH in postmenopause patients without bacterial pathogens .

References

Garcia . Closas M , Herrero R , Bratti C , Hildesheim A , Sherman M , Morera LA , Schiffman M . Epidemiologic determinants of voginal pH . Am J obstet . Gynecol 1999 ; 18 : 1060 – 6 .

Gorodeski GI , Hopfer U , Liu CC , Margles E. Estrogen acidifies vaginal pH by up – regulation of proton secretion via the apical membrance of vaginal–ecto ceroical epithelial cells . Endocrinology 2005 ; 146 : 816 – 24 .

American collage of obstetricians and gynecologists . Vaginitis . Washington : Amercan collage of obstetricians and Gynecologists ; 1996 . Technical Bulletin NO : 221 .

Association of professors of Gynecology and obstetrics . Diagnosis of vaginits . Washington ; Association of professors of Gynrcology and obstetrics ; 1996 . Educational series in women health Issues .

Hacker and Moore's , Essentials of obstetrics and Gynecology 2010 5th edition : 266 .

Keith E , Dewhurst's Textbook of obstetric and Gynecology 2007 ; 7th edition : 181 .

Faro S. vaginitis : diagnosis and management . Int J Fertil 1996 ; 41 : 115 – 23.5

Krohn MA , Hillier SL , Eschenbacli DA . Comparison of methods for diagnosing bacterial vaginosis among pregnant women JElin Microbiol 1989 ; 27 : 1266 – 71 .

Xu J , Bartoces M , Neale Av , Dailey RK , North rup J , Schwartz KL . Natural history of menopause symptoms in primary care patients : A metro net study . J Am Board Fam Pract 2005 ; 18 : 374 – 82 .

Garamszegi C , Dennerstein L , Dudley E , Guthrie JR , Ryan M , Burger H . Menopausal stats : subjectively and objectively defined . J Psychoson obstet Gynecolg 1998 ; 19 : 165 – 73 .

Burger HG . Diagnostic role of FSH measurement during the menopausal transition – analysis of FSH , estradiol and inhibin . Eur J Endocrinol 1994 ; 130 : 38 – 42 .

Boskey ER , Telsh KM , Whaley KJ , Moench TR , Cone RA. Acid production of vaginal flora in vitro is consistent with the rate and extent of vaginal acidification . Infect Immun 1999 ; 67 : 517 – 5 .

Mehzer RM . Chapter 37 : Vulvovaginitis . In : Sciarra JJ , editor . Gynecology and obstetrics . Philadelphia : JB Lippincott ; 1987 ; 1 – 13 .

Willson JR . Chapter 92 : the aging woman . In : Sciarra JJ , editor Gynecology and obstetrics . Philadelphia : JB lippincott ; 1987 ; 1 – 2 .

Galen RS , Gambino SR . Beyond normality : the predictive value and efficiency of medical diagnosis . New York ; Wiley , 1975 .

Platz – Christensen JJ , let al. A longitudinal follow up of bacterial vaginosis during pregnancy . Acta Obstet Gynecol Scand 1993 ; 72 : 99 – 102 .

Cailloutte JC , Sharp CF , Zimmer man GJ , Roys . Vaginal pH as marker for bacterial pathogens and menopausal status . AmJ obstet Gynecol 1997 ; 176 : 1270 – 7

Ernest JM , Meis PJ , Moore ML , et al. vaginal pH : a marker of preterm premature rupture of membranes . Obstet Gynecol 1984 ; 74 : 734 – 8 .

Stamey TA , Reid G , Iruin RT , Bruce AW , Costerton JW. Recurrent urinary tract infection in adult women : the role of introital enterobacteria . Califmed 1971 ; 115 – 9 .

Kelbanoff SJ , Hillier SL , Eschenbach DA , waltersdorph AM. Control of microbial flora of the vagina by H2O2 generating lactobacilli . J Infect Dis 1991 ; 164 : 94 – 100 .

Chan RC , Reid G , Irvin RT , Bruce Aw , Costerton JW. Competitive exclusion of uropathogens from human epithelial cells by lactobacillus whole cell and cell wall Fragments to Infect Imm 1985 ; 47 : 84 – 9 .

Amal Z Azzam , Wafaa M , Tarek A , Vaginal pH as marker for the per imenopause , A comparison with FSH . JMRI 2005 ; 26 : 273 – 78 .

Roy S , Cailloutte Jc , Roy T , Faden JS . Vaginal pH is Similar to follicle stimulating hormone for menopause diagnoses . Am J obstel Gynecol 2004 ; 190 : 1272 – 7 .

Baksu B , Icen M , Davas I ,Akyol A ,Varolan A,Yazgan A. Assessment of vaginal pH as marker of bacterial pathogens and menopausal status . Turkish J Fertil 2004 ; 12 : 180 – 6.

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2021-05-23

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