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May 24, 2021
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May 24, 2021
Published
May 24, 2021
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Abstract

Background: There has been an increase in the prevalence of otomycosis in recent years. This has been linked to the extensive use of antibiotics, use of immunosuppressant drugs and steroids for a variety of malignant and immunological diseases. Treatment of otomycosis is challenging, and requires a close follow-up; in addition treatment with topical or systemic antifungal drugs might be associated with problems of resistance, mucosal irritation, and systemic toxicities. Candida albicans and Aspergillus niger are the most commonly identified organisms.
Aim: the aim of this study is to investigate the antifungal potential of apple cider vinegar and acetic acid in a hope to find a safer alternative to traditional antifungal drugs in treatment of otomycosis.
Patients and methods: ear swaps were collected from 18 patients attending otolaryngology outpatient clinic-Al-Habboobi Hospital who presented with aural symptoms suggestive of otomycosis.fungal identification was done depending on microscopical and colonial morphology. Antifungal effect of the tested agents was assessed by agar well-diffusion assay.
Results: 18 samples were examined, 13 (72%) of them were positive for fungal growth, 6 were Aspergillus niger , 1 was Aspergillus flavus, 2 were Candida albicans, and the other 4 were Non- Candida albicans.
Apple cider vinegar(5%) inhibits growth of Aspergillus niger, Aspergillus flavus, Candida albicans and Non- Candida albicans with average diameter of inhibition zones of 15mm, 13mm, 17.5mm, 17 mm respectively, while the average diameters noted with acetic acid 2% were 10.5mm, 11mm, 13mm, 13.5mm respectively. Fluconazole (5mg/ml) inhibits growth of the Aspergillus niger, Aspergillus flavus with average diameters of 14mm,20mm respectively,while cause no inhibition of Candida albicans and Non- Candida albicans.
Conclusion: Apple cider vinegar and acetic acid have significant antifungal activity at the tested concentrations against Aspergillus niger, Aspergillus flavus, and fluconazole resistant Candida albicans and Non- Candida albicans.

Keywords

otomycosis apple cider vinegar acetic acid Candida Aspergillus

Article Details

References

  1. Ho T, Vrabec JT, Yoo D, et al; Otomycosis: clinical features and treatment implications. Otolaryngol Head Neck Surg. 2006 Nov;135(5):787-91. [abstract]
  2. Stern JC, Lucente FE. Otomycosis. Ear Nose Throat J 1988;67:804 –10.
  3. Garry JP; Otitis externa. eMedicine, November 2007.
  4. A. Jackman, R. Ward, M. April, J. Bent, Topical antibiotic induced otomycosis, Int J Pediatr Otorhinolaryngol 69 (2005) :857—860.
  5. Management of Common Otological Diseases at a Peripheral Medical Set Up
  6. Gp Capt RC Kashyap MJAFI 2003; 59 : 332-336
  7. V.J. Jadhav, M. Pal, G.S. Mishra, Etiological significance of Candida albicans in otitis externa, Mycopathologia 156 (2003) 313—315
  8. Georgiev V; Opportunistic Infections: Treatment and Prophylaxis 2003
  9. Bassiouny A, Kamel T, Moawad MK, et al; Broad spectrum antifungal agents in otomycosis. J Laryngol Otol. 1986 Aug;100(8):867-73. [abstract]
  10. P. Kurnatowski, A. Filipiak, Otomycosis: prevalence, clinical symptoms, therapeutic procedure, Mycoses 44 (2001) 472-479.
  11. Maher A, Bassiouny A, Moawad MK, et al; Otomycosis: an experimental evaluation of six antimycotic agents. J Laryngol Otol. 1982 Mar;96(3):205-13. [abstract]
  12. www.healthandfitnessforums.com/apple.html
  13. Corwin Brown:Health Benefits of Apple Cider Vinegar – Maintain Health.articlesbase,2008.
  14. pradhnya Tajni: Organic Apple Cider Vinegar.Buzzle.com.published 1/14/2010.
  15. Jack L. Pulec, Christian Deguine : Otomycosis - Otoscopic Clinic - Brief Article, Ear, Nose & Throat Journal, June, 2002
  16. Ravinder Kaur, Nalini Mittal, Manish Kakkar:otomycosis a clinicomycological study. Ear, Nose & Throat Journal , August, 2000
  17. Ali Zarei Mahmoudabadi: Mycological Studies in 15 Cases of Otomycosis: Pak J Med Sci October - December 2006 Vol. 22 No. 4 486-488)
  18. Abu-Mejdad M.J. Najwa: Evaluation of activity of some plant extracts against some fungi causes superficial cutaneous mycoses. 2005.
  19. Crockett, C.O.,F.Guede-Guina, D.Pugh: Cassia alata and the preclinical search for therapeutic agents for the treatment of apportunistic infections in AIDS patients. Cellular and molecular biology, 1992, 38: 799-802.
  20. G.H. Shahidi Bonjar: anti yeast activity of some plants used in traditional herbal-medicine of Iran, Journal of biological sciences 4(2): 212-215, 2004.
  21. Mugliston T, O’Donoghue G.: Otomycosis: a continuing problem.
  22. J Laryngol Otol 1985;99:327–33.
  23. T.J. Martin, J.E. Kerschner, V.A. Flanary: Fungal causes of otitis externa and tympanostomy tube otorrhea, Int J Pediatr Otorhinolaryngol 69 (2005) 1503—1508
  24. Finkel, Richard; Clark, Michelle A.; Cubeddu, Luigi X: Lippincott's Illustrated Reviews: Pharmacology, 4th Edition 2009.
  25. Pityrosporum Folliculitis – FAQ. Acne.org

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