PREVALENCE OF SUBCLINICAL HYPOTHYROIDISM IN PATIENTS WITH CHRONIC RENAL DISEASE IN AL-NASSIRYAH CITY

Authors

  • Wajdy J.Majid Biochemistry - College of Medicine - University of Thi Qar
  • Basim A.Muter Internal Medcine - College of Medicine - University of Thi Qar
  • Methaq Abdul-Mahdi

Abstract

Background :  Subclinical hypothyroidism is highly prevalent in the general populations especially in  elderly, however ,the prevalence of subclinical hypothyroidism in persons with chronic kidney disease is not well studied . Design : Cross sectional data from ( 245 ) persons , 110  persons of them considered as  a control group  and other persons (135 )with chronic kidney disease  , all of them were collected from ( 1-9-2010  to  1-7-2011 ) in Al – Hussein teaching hospital ( out patient and inpatient ). All patients and control group were routinely referred for thyroid function tests , renal function test ( in form of plasma creatinine) and estimation of glomerular filtration rate  ( GFR ). Multivariable logistic study was used to evaluate the independent association between prevalent subclinical hypothyroidism and estimated GFR . Results : Among ( 245 ) adult participants with serum creatinine , GFR   and thyroid function test results , the mean age for both groups were ( 58 ± 4 ) year ,  148  male while 97 of those were female. The prevelance of subclinical hypothyroidism increased specially with lower GFR     (  in unit of ml / min. / 1.73 m2 )  , occurring in 7.5 % of subject with GFR  (60 – 90 ml /min.) while those patients with GFR  less than ( 60  ml / min.) the prevalence were increased to  16.5 %  ( P < 0.001 ). The control group were 110  persons , only 3 participant with subclinincal hypothyroidism ( 2 % ). A significant difference when we  compared patient with chronic kidney disease and control group ( P < 0.001 ).

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2021-06-09

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