• Haider Sabah Kadhim Microbiology department college of medicine Al Nahrain University
  • Dhafer Abdullah Farhan Microbiology department college of medicine Thi- Qar University
  • Ausama Saadi Abdul muhsen Surgery department college of medicine Al Nahrain University


Survivin, TCC, IHC


Background: Bladder cancer is third most common malignant tumors in both men and women in Iraq. Transitional cell carcinoma ( TCC) account  for > 90% of bladder cancer. Survivin, family member of inhibitor of apoptosis (IAP) that play important role in both cell division and inhibit of apoptosis, Survivin express in vast majority of human cancer but not in normal adult tissues.

Objective:  to evaluate the possible role of Survivin in patient of transitional cell carcinoma of bladder.  

Materials and methods: formalin fixed, paraffin embedded tissue from (45) patients with transitional cell carcinoma of bladder from Al-Kadhimiya Teaching Hospital in Baghdad were included in this study. In addition, (16) apparently normal bladder biopsies were as a control groups. Tissue  blocks were sectioned for detection of Survivin by Immunohistochemistry(IHC).

Results: Survivin was not expressed in normal bladder urothelium, and it was over expressed in 71.1% (32/45) of TCC patients (p=0.001) . Overexpression of survivin was associated with tumor grade (p=0.029), although there was no significant association (p=731), but there was different in reading between Survivin expression and muscle invasion.

Conclusion: Survivin is  highly expression in  TCC in compared with normal urothelium, and play key roles in survival of neoplastic cells by negative regulating apoptosis, and its correlated with poor prognosis in cancer.


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