EMBRYOTOXICITY OF FLUOROQUINOLONES IN RATS

Authors

  • AL-Musawy A. A. H Department of Physiology, College of Vet. Medicine, Basrah University
  • AL-Myahi A. J Department of Physiology, College of Vet. Medicine, Basrah University
  • Al-Snafi Ali Esmail Department of Pharmacology, College of Medicine, Thi-Qar University

Abstract

This study was designed to investigate the possible developmental fetotoxicity and teratogenicity of Norfloxacin (NFX), Ciprofloxacin (CPX) and Enrofloxacin (ENX) in rats. Eighty pregnant female rats were divided into four equal groups, the first three groups were given daily single  oral doses of NFX,700mg/kg/day, CPX 550mg/kg/day, and ENX 750mg/kg/ day respectively and the last group was given dimethyl sulphoxide ( DMS) 0.5 ml/animal/day. All animals administered the drugs and the vehicle  from the day 1 to the day 15 of gestation period . Ten animals from each group were sacrificed at day 15 of gestation  by cervical dislocation, the other ten animal from each group were left till labor. Embryos and pups  were evaluated for litter size ,weight, resorption ratio, fetal lost and external features . The effect of drugs on the length of gestation period  was also  evaluated . The results revealed that  fluroquinolones were significantly decrease  litter size, and fetal weight, and increase fetal resorption ratio and fetal lost as compared to control either fetuses evaluated at day 15 of pregnancy or those  evaluated  after  birth . Gross examination showed some teratogenic abnormalities in fetuses and  pups of mothers treated with fluoroquinolones during the first 15 days  of  pregnancy .

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Published

2021-06-23

Issue

Vol. 5 No. 3 (2011)

Section

Articles