Clinical Study For Serum Lipid Profile And Lipid Peroxidation In Patients With Gallstones In Thi-Qar Governorate - Iraq
Keywords:
gallstones disease, gallbladder, lipid profile, MalondialdehydeAbstract
Objective: A gallstone (also called cholelithiasis) is a crystalline concretion formed within the gallbladder by accretion of bile components. These calculi are formed in the gallbladder but may distally pass into other parts of the biliary tract such as the cystic duct, common bile duct, pancreatic duct or the ampulla of Vater. Rarely, in cases of severe inflammation, gallstones may erode through the gallbladder into adherent bowel potentially causing an obstruction termed gallstone ileus..The study was designed to determine and compare the levels of lipid profile, and MDA in gallstones diseases and healthy individuals. Material and Methods: Blood lipid profile and malondialdehyde levels were determined in 50 gallstones Disease and 40 healthy subjects . Results:The levels of serum malondialdehyde and biochemical markers of body lipid profile (serum TCH,TG,LDL,VLDL) were showing significant increase in gallstones disease patients as compared to control group whereas the levels of HDL showed a significant decrease in gallstones disease patients in comparison to control subjects( P ≤ 0.01 ).. However we compared all measurement parameters for all groups according to type of disease.
Conclusion: In gallstones Disease, we finding a significant elevation in the levels of cholesterol and triglyceride during gallstones disease.
-Gallstones disease can effect on lipoproteins levels (high LDL, low HDL, and high VLDL. The increase in lipid peroxidation in gallstones disease, the increase in cholesterol, TG, LDL,VLDL . In gallstones disease lipid peroxidation can clearly occur.
References
Fitzgerald JEF, Fitzgerald LA, Maxwell-Armstrong CA, Brooks AJ "Recurrent gallstone ileus: time to change our surgery?". Journal of Digestive Diseases 10 (2):149151. doi:10.1111/j.17512980.2009.00378.x.PMID 19426399, 2009.
"Acute cholecystitis (MedilinePlus, A service of the U.S. National Library of Medicine)". Available on: April 26, 2013.
Wang DQ, Afdhal NH. Gallstone Disease. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran′s Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management, 9 th ed. Philadelphia, PA: Saunders; p. 1089-105, 2010.
- Yoo EH, Lee SY. The prevalence and risk factors for gallstone disease. Clin Chem Lab Med;47:795-807, 2009.
- Kim IS, Myung SJ, Lee SS, Lee SK, Kim MH (2003). "Classification and nomenclature of gallstones revisited". Yonsei Medical Journal 44 (4): 561–70.ISSN 0513-5796. PMID 12950109. Retrieved -11-06, 2010.
- N. A. Channa. Pak Arm Forces Med J. 58 ,197, 2008.
- G. Heiss, I. Tamir, C. E. Davis, and H. A. Tyroler. Circulation. 61 ,302, 1980.
- Mayne P.D. "Clinical Chemistry in diagnosis and Treatment", 6thedn. Eds. Arnold. 224-225,317,322, 2002.
- Rodenburg, K.W; Vander Horst, D.J; "Lipoprotein-mediated lipid transport in insects :Analogy to the mammalian lipid carrier system and novel concepts for the functioning of LDL receptor family members".Biochim.Biophs.Acta.1736:10-19; 2005.
- Malondialdehyde. Available from: http://en.wikipedia.org/wiki/Malondialdehyde. [Last accessed on Mar 26], 2012.
- Wang DQ, Afdhal NH. Gallstone Disease. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran′s Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management, 9 th ed. Philadelphia, PA: Saunders;. p. 1089-105, 2010.
- Jüngst C, Sreejayan N, Eder MI, von Stillfried N, Zundt B, Spelsberg FW, et al. Lipid peroxidation and mucin secretagogue activity in bile of gallstone patients. Eur J Clin Invest;37:731-6, 2007.
- Fong, K.L., McCay, P.B., and Poyer, J.L., J. Biol. Chem. 248:7792; 1973.
- Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterol.;122:1500-11, 2002.
- Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am;20:1-19, 1991.
- Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet.;368(9531):230-9, 2006.
Scragg RK, Calvert GD, Oliver JR. Plasma lipids and insulin in gall stone disease: a case-control study. Br Med J (Clin Res Ed). Sep 1;289(6444):521-5, 1984.
Chapma BA, Wilson IR, Frampton CM. Prevalence of gallbladder disease in diabetes mellitus. Dig Dis Sci.;41(11):2222-8, 1996.
Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Hepatology. 8 ,907, 1988.
Gutteridge JM. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem.;41:1819–28, 1995.
Jüngst C, Sreejayan N, Zundt B, Muller I, Spelsberg FW, Huttl TP, et al. Ursodeoxycholic acid reduces lipid peroxidation and mucin secretagogue activity in gallbladder bile of patients with cholesterol gallstones. Eur J Clin Invest;38:634–9, 2008.
