ANTIBODIES AGAINST ERYTHROCYTES ENHANCE INVASION OF MOUSE RETICULOCYTES
Abstract
SUMMARY Twenty mice were injected i.p. with 1x105 P. berghei infected red cells . Blood smears of these mice were prepared daily till the mice were died . Mice were categorized in three groups depending on similar type of course of parasitaemia after inoculation . Seven mice of Group A (A1 – A7) showed similar type of behavior and died due to low parasite infection . Another group of seven mice (B1 to B7) showed a gradual increase in parasitaemia till mice died due to high infection . Group C (C1 to C6) smears showed a vary rise and fall in infection and all the mice were cleared of parasite infection . The antibody titre as detected by IFA , observed in these groups was 1 : 2048 , 1 : 1024 and 1 : 4096 in groups A , B and C respectively . The group C which showed protective immunity against P . berghei infection depicted strong fluorescence against normal erythrocyte membrane too . The fluorescence against normal RBCS membrane was observed very weak in group A , whereas it was negligible in group BReferences
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