Role of Interleuken-6 & Tumor necrosis factor – α in Rheumatoid arthritis Patients in Nassiriyah governorate

Authors

  • Adnaan Taan AL-Khafaji Department of Internal Medicine College of Medicine University of Thi-qar, Iraq

Abstract

SUMMARY The present  study has been done in Al-Nassiriyha, southern Iraq, from December 2006  to August 2007,designed to determine the role of Interleuken-6 and Tumor necrosis factor – α  in a group of patients with rheumatoid  arthritis for specific period of time and healthy controls, and to show the diagnostic value of IL-6 and TNF-α in relation to rheumatoid factor (RF) to discriminate between those patients with and  without RA . Blood samples were taken from 121  patients  with  rheumatoid  arthritis from AL-Hussein Teaching Hospital in AL-Nassiriyah and 120 healthy controls from  medical personnel  and school  students who  were  healthy . All the information were taken from the patients and controls. An Enzyme-linked immunosorbent assay was used for estimation IL-6, TNF-α and slide agglutination test for the estimation of RF.    The seropositivity to IL-6 and TNF-α and RF in  patients  with rheumatoid  arthritis was  ( 60% , 56.1% and 57%  respectively ) .The study revealed that specificity of TNF- alpha was higher than IL-6 and RF ( 96.6 % , 92.5 % and 81.6 respectively ) .  

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2021-09-12

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