The nephroprotective effect of some vasodilators and vitamins in experimental model of acute renal failure
Keywords:
nephroprotective, vasodilators, vitamins, acute renal failureAbstract
Background: Myoglobinuric ARF is an example of intrinsic type of renal failure induced by intramuscular injection of glycerol. Materials and methods: this study has been conducted using 36 local domestic rabbits. They were separated in to 6 groups, each one has been pre-treated with a test agent (vitamin C and E, amlodipine, carvedilol and verapamil) 2 hours prior to administration of glycerol. The changes in renal function have been followed up by monitoring the levels of BUN, serum creatinine, K+and Na+ after 3 and 7 days of the induction.Results: pretreatment with vitamin C, vitamin E, carvedilol and verapamil cause significant reduction in the levels of BUN, serum creatinine and K+ and significant elevation of serum Na+when compared with the control group. While pretreatment with amlodipine causes significant elevation of BUN, serum creatinine and K+. Conclusion: Vitamin C, E, carvedilol and verapamil have a significant nephroprotective effect at the tested doses in this model of acute renal failure with a possible use in prevention of acute renal failure.References
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