SERUM LEVEL OF VITAMIN C IN MALIGNANCY
Keywords:
Vitamin C, Different types of malignancy, Non – malignant patientsAbstract
The present paper reports selected results of 184 surgical patients in Basrah. They were 82 males and 102 females. Their ages ranged between 22-84 years. From those, 100 patients had different malignancies. 43% from the total number, of malignant tumors with gastrointestinal GIT cancer, while breast cancer and malignancy of urinary systems each represents 18%. And the other types of malignancy were 21%. The remaining 84 patients were suffering from surgical ailments other than malignancy. Their serum vitamin C were measured. The results showed high significant reduction in serum Vitamin C in all type of malignancy , specifically in GIT (P< 0,00l)in respect to age mainly at the age less than 45 and between 45-65 years old, as well as sex and nutritional habit mainly among those consuming fruit and Vegetables less than 3 times per week. Therefore, we conclude that serum Vitamin C are measurable biochemical indices that can be used as predictors for following those patients during and after treatments.References
Gut brie HA., Picciano MF., Human Nutrition. New York. Mosby year book, INC. 1995.21- 24.
Word low GM., Insel PM. Perspectives in nutrition. Philadelphia : Mosby, 1996.
Mayes PA. structure and function of the water soluble vitamins. In : Murray RK., Granner PK., Mayes PA. Harper’s Biochemistry 24th ed., California. Appleton and Lange company. 1996; 599- 613.
Pryor WA. The antioxidant nutrients and disease prevention what do we know and what do we need to find out? Am .J. Clin. Nutr. 1991; 53: 391-393.
Car Ac., Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am , J. Clin. Nutr. 1999; 69: 1070- 1086.
Meydani M., Martin A., Gong J., etal. B- carotene supplementation in creases antioxidant capacity of plasma in older women. Nutrition. 1994; 24: 2397- 2404.
Block G. Vitamin C and cancer prevention. The epidemiologic evidence. Am. J. Clin . Nutr. 1991, 53: 270- 272.
Toro G., Ackermann PG. Practical clinical chemistry.1st . ed. Boston: Little, Brown and Company, 1975; 634- 636.
Anderson R. Assessment of the roles of vitamin C, vitamin E and B carotene in the modulation of oxidant stress mediated by cigarette smoke- activated phagocyte Am J. Clin. Nutr 1991; 53: 358- 361.
Lee IM. Antioxidant vitamins in the prevention of cancer. Proc- Assoc. Am. Physicians. 1999; 111 (1): 10-15.
Anderson L. Dibble MV., Turkkipr., etal. Nutrition in health and diease.17th ed. Philadelphia :J. B. Lippincott Company, 1982.
Sealy WM., Gatlin DM. Dietary vitamin C and E interact to influence growth and tissue composition of Juvenile Hybrid Striped Bass (moron chrysops female symbol xm. Saxatitis male symbol) but have limited effects on Immune Responses. J. Nutr. 2002;132:748-755.
Houser G., Vojdani A. Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals. The role of protein kinase – C. Immuno pharmacol. Immuno toxicol. 1997; 19 (3), 291- 312.
Haskell BE., Johnston CS., Complement component C19 activity and ascorbic acid nutritive in guinea pigs. Am. J . Clin. Nutr. 1991; 5416 suppl:1228- 1230.
Yang CS. Vitamin nutrition and gastro esophageal cancer . J. Nutr. 2000; 130 (25 supple) 338- 339.
Tannenbaum SR., Wishnok JS, Leaf CD. Inhibition of nitrosamine formation by ascorbic acid. Am .J. Clin Nutr 1991; 53:247- 250.
Zhang HM., Wakisaka N., Macda O., etal. Vitamin C inhibit the growth of a bacterial risk factor for Gastric Carcinoma. Helicobacter pylori. Cancer 1997; 80: 1896- 1903.
Choi MA, Kim BS, YuR. Serum anti oxidative vitamins levels and lipid peroxidation in gastric carcinoma patients. Cancer. Lett . 1999., 136 (1): 89-93.
Graham S., Mettle C., Marshal J, etal. Diet in epidemiology of cancer of larynx. Am. J. epidemiology, 1981; 113 (6) 675- 680.
Hughes DA. Effect of dietary antioxidants on the Immuno Function of middle aged adult., Proc. Nutr. Soc.1999; 58 (1): 79- 84.
