A Study of Prolactin, Thyroid Stimulating Hormones, Malondialdehyde and Ceruloplasmin Levels in Infertile Women, in Thi-Qar Governorate/Iraq
OBJECTIVES: The study designed to investigate the level of prolactin (PRL), thyroid-stimulating hormones, Malondialdehyde (MDA) and ceruloplasmin (Cp) levelsof the groups of infertile and fertile females in Nasiriyah province, southern Iraq.
METHODOLOGY: Blood samples were collected from two groups of females (females with infertility and fertile women) with a total number of 99 infertile women and 70 fertile females at Bent Al-Huda maternity and children teaching hospital in Thi-Qar governorate. Autoanalyzercobas e411 instrument was used to estimate of prolactin, Thyroid-stimulating hormones and Ceruloplasmin levels in sera of patients and control group using Elecsys and cobas immunoassay analyzers. The MDA level of the serum was measured by the modified method of Fong et al. (1973). The concentration of plasma MDA was computed according to the equation of coefficient of MDA equal to 1.56 x103mol-1. cm-1.
RESULTS: Prolactin and TSH levels were significantly increased (p< 0.0001) in infertile females as compared to fertile women. A similar pattern was observed to concentrations of MDA and Ceruloplasmin were significantly increased (p < 0.0001) in patients when compared to control group.
CONCLUSION:The results of this study indicate that oxidative stress does occur in infertile females. Patients with infertility showed are higher significant rise in serum Prolactin hormone and thyroid-stimulating hormone levels in infertility patient group. All the patients with a high Prolactin level should have TSH estimation.
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