VALUE OF SERUM CALCIUM, PHOSPHATE, PROTEIN AND ALKALINE PHOSPHATAES IN ELDERLY POPULATION
Keywords:Calcium, phosphate, protein, alkaline phosphatase, elderly
AbstractObjective: The aim of this study was to investigate the value of serum calcium (Ca), phosphate (P), total protein (TP) and alkaline phosphatase (AIP) activities in elderly patients, to know the levels of those biochemical p parameters and to clarify the relationships of these finding with the diseases that having specially over the life Study design: A prospective case control study conducted at the biochemistry Department, through a period of 1 year from the first of October 1999 till the end of October 2000.Base line samples were collected to measure S. Ca, P,TP and AIP activities in 110 elderly patients aged 72± 6.5 years (62 males and 48 females) and the effects of biological factors (age, sex, and weight) and large set of pathological conditions were examined and for comparison, another 100 subjects aged 68±8 years (63 males and 37 females) whom, were found free of any disease and or alcoholic and smoking habit considered as a control group. Results: The results of the study showed a significant decreased (p<0.05) in the concentrations of S.Ca and TP and a significant increased (P<0.05) in the concentrations of S. P and AIP activity in hypertensive and in patients how have renal failure. A significant increased (P<0.05) in the S.Ca, P and AIP activity and a non – significant decrease (P>0.05) in the TP level, were observed in the patients having bone and joint diseases. The values of S. P in the patients having heart disease shows a significant increased (P<0.05) and non – significant changes (P>0.05) in the concentrations of serum Ca, TP and AIP activity is often considered. Non significant alterations (P>0.05) was observed in those biochemical parameters in relation to diabetes mellitus or other pathological conditions. Conclusion: We conclude that, the measurements of those biochemical's parameters in elderly populations was useful to know some of theories of aging that might take place in the cell, an organ or total organism with a passage of time, and also the sequential or progressive change in an organism that leads to an increased risk of debility, disease and death.
Harrison's. Principle of internal medicine. New York, McGraw, Vol.1.14ih edn, 37-39,1998.
Lackie TM, Mor AR. Cell and tissue in health and diseased, 1997, cited in Macsween RNM, Wholey, eds. Murist text book of pathology, 13ih edn, Glasgow. ELBS with Edward Arnold.
Http/www-cd.guv,nchs,datahus, hus 0.8pdf#026.
Meyer, Julie (2001). Genus's 2000 Briet, C2KBR/01-12, U,S, census Bureau.
Muir's: Text book of pathology. 1997, 13 th edn, MacSween RN and Whaley (cd) Edward Arnold.
World Health Organization: Prevention and management of hypertension EMROT, Technical publication series 23. Regional office for Eastern Mediterranean, WHO,1996.
European Transplantation and Dialysis Association. Repot on management of renal failure in Europe, XXIV, 1993: Nephrol Dial Transplant 10 [Supp15]:12,1995.
US Renal Data System : Causes of Death. Annual Data Repot, Vol.14. Bethesda, MD. The national institute of health, National institute of Diabetes and Digestive and kidney Diseases, 1995.
Slatopolsky E, Lopez Hilker S, Delmez J, Dusso A, Brown A, Martin K J: The parathyroid – Calcitriol axis in health and chronic renal failure. Kidney Int Suppl 29: S41-S47, 1990.
Gonzales EA, Martink J: Renal Osteodistrophy: Pathogenesis and management. Nephrol Dial Transplant, 3: 13-21, 1995.
Jakoby MQIV, Semenkoxich CF: The role of osteoprogenitors in vascular calcification. Curr Opin Nephrol Htpertens, 9: 11-15, 2000.
Panela cc; Richard AH; Denise RF. Lippincott's Illustrated Reviews Biochemistry, Lippin cott Williams and Wilkins, 355, 2005.
Hunter D j. Hart D, Snieder H, etal. Evidence of altered bone turnover, Vitamin D and calcium regulation with knee osteoarthritis. Rheumatology (oxford). 42(11); 1311-6 E. 2003.
Schinella RA and Becker FF. Cirrhosis. In Beker FF(ed). The liver Normal and Abnormal functions, part B Marcel, Dekker, Inc, New York. 7, 11-23, 1995.
Brodkin CA, Moon JD, Comp I, Echeverria D, etal. Serum hepatic biochemical activity in two populations of workers exposed to styrene. Occup- Environ- Med, 58 (2): 95-102, 2001.
Burtis CA, A shwood ER Tietz text book of clinical chemistry 2nd edn. W. B.Senders company, a division of Harcourt Brace and company. Philadelphia London. 1999.