Solitary Non-Thrombotic Elevation in D-Dimer after COVID-19 Pfizer Vaccine: A Case Report
AbstractD-dimer is sensitive and early marker of both inflammatory and thrombotic insult, extremely elevated D-dimer might herald a serious events especially following receiving a shot of COVID-19 vaccine. The adverse effects of COVID-19 vaccine is simulating the rare but catastrophic thrombotic events following vaccination.so early alertness to this complication mandate search for this serious entity. D-dimer although non-specific but it is highly sensitive and early marker of thrombotic as well as other serious pathologies, we present a case with nonspecific symptoms with the only laboratory abnormality is lonely elevation in D-dimer. To our knowledge this is the first reported case of elevated D-dimer without clinically manifest thrombosis highlighting to possible newly emerging practice of using D-dimer as an early evidence of hidden thrombosis.
Haifeng w,Daniel J.B,Brad R,et al.D-Dimer Level and the risk for Thrombosis in Systemic Lupus Erythematous. Clinical Journal of the American Society of Nephrology:CJASN.2008Nov;volume:3,issue(6):pages:1628- 1636.doi:10.2215/CJN.01480308.
Maria E d l M,Carlos B,Antonia M,et al.Prognostic Value of thrombin generation parameters in hospitalized COVID-19 patients. Scientific Reports.2021;11:7792.doi:10.1038/s41598-021-85906-y.PMCID:PMC8032761.PMID:33833254.
Prachee M.Sathe and Uravil D.Patwa,at al.D Dmier in acute care. International Journal of Critical Illness and Injury Science..2014 Jul-Sep;4(3):229-232.doi:10.4103/2229-5151.141435.PMCID:PMC4200549.PMID:25337485.
Schutte T,Thisjs A,Smulders YM.et al.Never ignore extremely elevated D-dimer levels: they are specific for serious illness. The Netherlands Journal of Medicine,01 Dec 2016,74(10):443-448.PMID:27966438.
Stavros V.Konstantinides.Thrombotic complications of vaccination against SARS-CoV-2:what pharmacovigilance reports tell us-and what they don't. The European Respiratory Journal.2021 Jul;58(1):2101111.doi:10.1183/13993003.01111-2021.
Rahul C.MBA,Lalaj G.et al.Thromboinflammatory biomarkers in COVID-19:Systemic Review and Meta-analysis of 17,052 patients.Mayo Clinic proceedings:Innovations,Quality&Outcomes.volume 5,Issue 2,April 2021,pages 388-402.