The Effects of Methionine on Paracetamol Induced Live Injury ( Hepatomegaly ): An Animal Study

Abstract

own to restore hepatic glutathione) could prevent acetaminophen-induced hepatic injury. Use of these agents resulted in dramatic increases in survival, but the side effects (flushing, vomiting, and “misery” associated with these therapies led researchers to seek alternative treatment(7). This study which was done for a total (45) mice, over a time of 30 days, reflects that paracetamol overdoses causing hepatic enlargement with high significant results (P<0.0001), although combined together with Methionine and by the same intra-gastric route of administration, with no any hepatoprotective effectiveness of Methionine, that there is no significant results (P=0.1566). Also this study reflects; that there were no any effect of Methionine on the ratio of the liver wt. / body wt. of the mice, in which the (P=0.1668 "no significant results), against paracetamol over-doses induce hepatomegaly, while paracetamol was highly significant (P=0.0001) on this ratio, when compared with control group.