Clinical Characters in Diabetic Patients affected by Oral fungal Infection in Dhi-Qar City

Authors

  • Fadhil Saeed Waheed M.B.Ch.B., MSc. Pharm., Health Directorate, Alnassiryia Teaching Hospital, Dhi-Qar, IRAQ, 2021-2022

Abstract

Background: Different studies conducted nationally and internationally to find out the different factors for oral fungal infection in the diabetic patients. The connection between hyperglycemia and fungal  infection has been studied extensively. However, this issue is underexplored in Dhi-Qar context. This study aimed to investigate the incidence of oral fungal infections among patients with diabetes were diagnosed and treated in Alnassiryia Diabetes center , Alnassiryia teaching hospital and Consultant Clinics in Dentistry College in Dhi-Qar city. Method               This is a cross-sectional, study was conducted on Diabetic patients from different healthcare centers , living in different areas in  Dhi-Qar governorate. It was carried out during the period from first of November 2021 to 20th  of February 2022, where a 145 diabetic patients of both sexes ,who previously diagnosed with diabetes, presented with various oral cavity and other systemic diseases, were enrolled in this study by using simple random sampling technique , and the oral cavity for each one was examined clinically . Data were collected through a predesigned questionnaire covering medical history of diabetes with multiple  demographical and clinical characteristics of patients and , Microsoft Excel for Window version 2010 was used for data management and descriptive statistics were analyzed by SPSS version 20.0. Results:             The current work found that there were significant associated of  a state of poor or bad oral hygiene , and type of diabetes therapy especially in those patients that used life style changes , or those  using   insulin with oral hypoglycemic drugs on the risk of oral fungal infection. The older the patient , comorbidities as  respiratory tract infections , Cardiovascular system infections  , Gastrointestinal tract infections , and kidney diseases  and the smoking type social habit for diabetes patients , the higher probability they get oral fungal infection (p<0.05). Conclusions:      Oral fungal infection is prevalent, while presence  of poor or bad oral hygiene , and type of diabetes therapy along with poor glycemic control and with the higher age group of the patients  presence of comorbidities , and those of  smoking type  social habit . are the most important factors affecting the incidence of fungal infections in oral cavity.

References

Thoai Dang Nguyen , Tram Thi Huyen Nguyen, Quang Vinh Tran.,

The incidence of oral candidiasis in patient with diabetes mellitus :

A cross-sectional study in southern Vietnam. Journal of Critical Reviews, 2020.7(4):p.82-86.

Alanazi, N.H., et al., Prevalence of diabetes and its relation with age and sex in Turaif city, northern Saudi Arabia in2016–2017. Electronic physician, 2017. 9(9): p. 5294.

King, H., R.E. Aubert, and W.H. Herman, Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes care, 1998. 21(9): p. 1414-1431.

Agarwal, S., et al., Sankara Nethralaya—Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN—DREAMS 1): Study Design and Research Methodology. Ophthalmic epidemiology, 2005. 12(2): p. 143-153.

Bramono, K., et al., Comparison of proteinase, lipase and alpha-glucosidase activities from the clinical isolates of Candida species. Japanese journal of infectious diseases,2006. 59(2): 73.

World Health Oranganization, Diabetes Fact sheet N°312. 2014, World Health Oranganization: Geneva.

Renata S Leite, Nicole M Marlow, Jyotika K Fernandes, Kathie Hermayer.Oral health and type 2 diabetes .Am J Med Sci. 2013 Apr;345(4):271-273.

World Health Oranganization, About diabetes. 2019, World Health Oranganization: Geneva.

Barbara K Bailes .Diabetes mellitus and its chronic complications

AORN J. 2002 Aug;76(2):266-76, 278-82; quiz 283-6.

Mariko Higa. [Clinical epidemiology of fungal infection in diabetes]

Nihon Rinsho. 2008 Dec;66(12):2239-44

Anna Poradzka 1, Mariusz Jasik, Waldemar Karnafel, Piotr Fiedor.

Clinical aspects of fungal infections in diabetes. Acta Pol Pharm. Jul-Aug 2013;70(4):58796

Mea Bissong, C C Azodo, M A Agbor, T Nkuo-Akenji, P Nde Fon .Oral health status of diabetes mellitus patients in Southwest Cameroon. Odontostomatol Trop. 2015 Jun;38(150):4957.

Shi, Y. and F.B. Hu, The global implications of diabetes and cancer. Lancet (London, England), 2014. 383(9933): p. 1947.

Davenport, J., The oral distribution of candida in denture stomatitis. Brit. dent. J., 1970. 129(4): p. 151-156.

International Diabetes Federation, Annual Report 2014. 2014.

Darwazeh, A., et al., The relationship between colonisation, secretor status and in-vitro adhesion of Candida albicans to buccal epithelial cells from diabetics. Journal of medical microbiology, 1990. 33(1): p. 43-49.

Brownlee, M., A. Cerami, and H. Vlassara, Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. New England Journal of Medicine, 1988. 318(20): p. 1315-1321.

Tang, H.J., et al., Epidemiology and prognostic factors of candidemia in elderly patients. Geriatrics & gerontology international, 2015. 15(6): p. 688-693.

Akpan, A. and R. Morgan, Oral candidiasis. Postgraduate medical journal, 2002. 78(922): p. 455-459.

Masato Nakajima , etal . Association between oral candidiasis and bacterial pneumonia: A retrospective study. Oral Dis 2020 Jan;26(1):234-237.

Marie Laurent, Bruno Gogly, Farzad Tahmasebi, Elena Paillaud .[Oropharyngeal candidiasis in elderly patients]. Geriatr Psychol Neuropsychiatr Vieil 2011 Mar;9(1):21-8.

SUMMARY

This study was described the prevalence of oral fungal infections among selected Diabetic patients were living in different areas in Dhi - Qar governorate. It was carried out during the period from first of November2021 to 20th of February 2022, where a 145 Diabetic patients were enrolled in this study . Oral fungal infections in diabetes patients is widely prevalent, with specificity to word poor or bad oral hygiene were the most frequently factor that presented as a risk factor for developing an oral fungal infections in selected diabetes patients (majority of them) , followed by the type of diabetes therapy , the most frequently reported therapy is those on life style changes , and those using oral hypoglycemic drugs with insulin at the same time . Other risk factors for developing fungal infections in oral cavity inselected diabetes patients , as older age group especially those with age group (45- 60y), presence of comorbidities , and those of smoking type social habit .

Downloads

Published

2023-01-04

Issue

Section

ARTICLE