Vitamin D Deficiency and Clinical Outcomes in Patients with COVID-19
Keywords:
COVID-19, severity, 25OH-Vitamin D, CR-Protein, inflammatory responseAbstract
Background: COVID-19, also known as the new coronavirus, has been linked to a variety of clinical outcomes, including moderate respiratory symptoms, severe respiratory failure, multi-organ failure, and death. The disease's severity can vary depending on a number of factors, including age, pre-existing medical disorders, and immunological function. Aim: The aim of this study was to monitor the 25OH-Vitamin D serum level with clinical outcomes including CRP for patent’s infected with SARS-CoV-2. Method: In this study a total of 59 patients and 25 normal cases (for control) were enrolled for investigation the role of Vitamin D in the disease severity in patients infected with SARS-Cov-2. Results: The result showed a significant decrease of vitamin D in abnormal group compared with normal group (15.74±5.63 vs 33.41±12.18 ng/dl, p = 0.0001). Additionally, the patients in infected group (6.7±12.64) had significantly (p<0.0001) lower CRP level in comparison with control group (1.77±3.12). There are no significant differences reported (0.612) in ages between the infected COVID-19 group 38.35±6.15 and control group (37.85 ± 7.28). Furthermore, The RT-PCR had no significantly reported differences between COVID-19 cases and control group 29.98±5.25 vs 39.89 ± 5.01. Conclusion: we found that COVID-19 patients with vitamin D deficiency were more likely to increase the risk of severe COVID-19 infection and complications; it helps regulate the body's inflammatory response, which is important in fighting off infections.References
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