The Main Bacterial Isolates Associated with Chronic Obstructive Pulmonary Disease in Thi Qar Province
AbstractBackground: Chronic obstructive pulmonary disease (COPD) is a well-known, preventable, and curable condition. Frequent respiratory symptoms and a reduction in airflow caused by abnormalities in the airways and/or alveoli are its defining features (1). The prevalence of COPD is 10 % in people over forty years old whereas COPD prevalence in Iraq among adult smokers is 15.1% (2). Infections are the principal source of acute exacerbation of COPD (AECOPD (and these infections are implicated in 40% to 60% of exacerbation cases. Worldwide, a variety of bacteria, such as Pseudomonas aeruginosa, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, are recognized to cause AECOPD (3). Aim: The aim of this work was to identify the main bacterial isolates associated with COPD. Method: This study included 70 patients (46 males and 24 females) suffered from COPD. All these patients were detected through a full medical examination, and chest examination, such as a spirometry. Sputum samples were collected and processed, followed by performing gram staining and culturing. The main isolates were identified using Vitek II systems. Results: According to results of this study, Pseudomonas aeruginosa was found to be the predominant cause of COPD infections, with Klebsiella pneumonia following closely in frequency. Conclusion: In conclusion, Pseudomonas aeruginosa and Klebsiella pneumonia have been identified as the main bacterial infections associated with COPD.
GOLD. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. www.goldcopd.org. 2022.
Wang K, Mamidipalli A, Retson T, Bahrami N, Hasenstab K, Blansit K, et al. Automated CT and MRI Liver Segmentation and Biometry Using a Generalized Convolutional Neural Network. Radiol Artif Intell. 2019 Mar;1(2).
Ayobami O, Willrich N, Suwono B, Eckmanns T, Markwart R. The epidemiology of carbapenem-non-susceptible Acinetobacter species in Europe: analysis of EARS-Net data from 2013 to 2017. Antimicrob Resist Infect Control. 2020 Dec;9(1):89. Available from: https://aricjournal.biomedcentral.com/articles/10.1186/s13756-020-00750-5
SEEMUNGAL TAR, DONALDSON GC, BHOWMIK A, JEFFRIES DJ, WEDZICHA JA. Time Course and Recovery of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2000 May;161(5):1608–13. Available from: https://www.atsjournals.org/doi/10.1164/ajrccm.161.5.9908022
Sethi S. Bacteria in Exacerbations of Chronic Obstructive Pulmonary Disease: Phenomenon or Epiphenomenon? Proc Am Thorac Soc. 2004 Apr;1(2):109–14. Available from: http://pats.atsjournals.org/cgi/doi/10.1513/pats.2306029
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005 Aug;26(2):319–38. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16055882
Talatam A, K. Reddy P, Pragati Rao D, Vineela S, Yamuna K. Bacteriological profile of acute exacerbations of chronic obstructive pulmonary disease. IP Indian J Immunol Respir Med. 2020 Dec 28;3(3):98–102. Available from: https://ijirm.org/article-details/7449
Sharma P, Narula S, Sharma K, Kumar N, Lohchab K, Kumar N. Sputum bacteriology and antibiotic sensitivity pattern in COPD exacerbation in India. Egypt J Chest Dis Tuberc. 2017 Oct;66(4):593–7. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0422763817301747
Abden H, Hafez M, Eltrawy H. Sputum bacterial profile and antibiotics sensitivity pattern in acute exacerbation of chronic obstructive pulmonary disease. J Recent Adv Med. 2020 Dec 29;0–0. Available from: https://jram.journals.ekb.eg/article_133603.html
Erkan L, Uzun O, Findik S, Katar D, Sanic A, Atici AG. Role of bacteria in acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3(3):463–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18990975
Moghoofei M, Azimzadeh Jamalkandi S, Moein M, Salimian J, Ahmadi A. Bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Infection. 2020 Feb;48(1):19–35. Available from: http://www.ncbi.nlm.nih.gov/pubmed/31482316
Sobhy KE, Abd El-Hafeez AM, Shoukry FA, Refaai ES. Pattern of sputum bacteriology in acute exacerbations of chronic obstructive pulmonary disease. Egypt J Bronchol. 2015 Aug 4;9(2):170–7. Available from: https://ejb.springeropen.com/articles/10.4103/1687-8426.158065
Basu S, Mukherjee S, Samanta A. Epidemiological study of bacterial microbiology in AECOPD patients of Kolkata, India. Asian J Pharm Clin Res. 2013;6(1):112–6.
Rakesh G, Kasturi T, Yuvarajan S. Bacterial agents causing acute exacerbations in Chronic Obstructive Pulmonary Disease (COPD) patients, their antibiograms to Extended Spectrum Beta-Lactamases (ESBL) production in a tertiary care hospital, India. Int J Curr Microbiol Appl Sci. 2013;2(11):273–82.
Ma X, Cui J, Wang J, Chang Y, Fang Q, Bai C, et al. Multicentre investigation of pathogenic bacteria and antibiotic resistance genes in Chinese patients with acute exacerbation of chronic obstructive pulmonary disease. J Int Med Res. 2015 Oct;43(5):699–710. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26152913
Mussema A, Beyene G, Gashaw M. Bacterial Isolates and Antibacterial Resistance Patterns in a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in a Tertiary Teaching Hospital, Southwest Ethiopia. De Francesco M, editor. Can J Infect Dis Med Microbiol. 2022 Aug 31;2022:1–11. Available from: https://www.hindawi.com/journals/cjidmm/2022/9709253/
Shimizu K, Yoshii Y, Morozumi M, Chiba N, Ubukata K, Uruga H, et al. Pathogens in COPD exacerbations identified by comprehensive real-time PCR plus older methods. Int J Chron Obstruct Pulmon Dis. 2015 Sep;4(1):2009. Available from: https://www.dovepress.com/pathogens-in-copd-exacerbations-identified-by-comprehensive-real-time--peer-reviewed-article-COPD
ElFeky DS, Elmandory HM, Galal M, AbdelHakim M. Sputum Bacteriology in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Int J Curr Microbiol Appl Sci. 2016 Jan 10;5(1):289–305. Available from: http://www.ijcmas.com/abstractview.php?ID=28&vol=5-1-2016&SNo=28
European Respiratory Society Annual Congress 2012. 2012;(14):7–8.