Assessment of Xanthine Oxidoreductase level with Zinc and Magnesium in Sample of Patients with Inflammatory Bowel Disease in Babylon Province


  • Ban Mahmood Shaker Al-joda Department of Biochemical, College of Medicine,University of Babylon, Iraq
  • Akan Khanjar Nasrullah College of Medicine, University of Babylon, Iraq
  • Hassan Salim Aljumaily Department of Biochemical, College of Medicine, University of Babylon, Iraq


Inflammatory bowel disease, Xanthine oxidoreductase, zinc, magnesium


Background: Inflammatory bowel disease affects the colon and small intestine, with Crohn's disease and ulcerative colitis being the most frequent types. Xanthine oxidoreductase (XOR), a dehydrogenase enzyme, is expressed in all cells. Its activity is usually modest. During phylogenesis, the mammalian XOR enzyme regulates ROS and NO production. Objective: The objective of this study is to quantify the levels of Xanthine oxidoreductase and investigate any possible associations between zinc and magnesium in the context of inflammatory bowel disease in Babylon province. Materials and Methods:  Xanthine oxidoreductase levels were evaluated in 100 people: 50 with inflammatory bowel disease and 50 with healthy people. The study participants and the healthy controls varied in age from 15 to 65. The enzyme-linked immunosorbent assay (ELISA) method measured xanthine oxidoreductase while Iron was in the spectrophotometer in the serum. And used a case-control analysis as study design. Ethical Approval a-Approval of the scientific committee in the Biochemistry Department of Babylon Medical College. b-Approval of the scientific committee of Marjan Medical City in Hilla city, Babylon province. c-The objectives and methodology of this study were explained to all participants in the current research to gain their verbal acceptance. Results:  The serum xanthine oxidoreductase was greater in IBD patients than in controls (p 0.01). In contrast, the current study discovered a negative association between zinc and magnesium in IBD patients (p 0.05) and a non-significant relationship between xanthine oxidoreductase, zinc and magnesium in IBD patients (p > 0.05). Conclusion: There is a significant association between IBD and high xanthine oxidoreductase levels in Babylon province patients.


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