The Correlation between Vitamin D Status and Glycosylated Hemoglobin Levels
Keywords:
Vitamin D, HbA1c levels, ANOVA analysis, normoglycemic, prediabeticAbstract
Background: The intricate relationship between Vitamin D levels and glycemic control inindividuals with varying HbA1c levels has been a topic of significant research interest due to its
potential implications for diabetes management. This study aimed to explore the association
between Vitamin D classifications and HbA1c levels across different glycemic states and genders.
Methodology:
Using ANOVA analysis, we examined HbA1c levels across four Vitamin D classification groups
(Vit D 1, Vit D 2, Vit D 3, Vit D 4). Pairwise comparisons were conducted, and glycemic situations
(normoglycemic, prediabetic, and diabetic) were analyzed across these Vitamin D groups. Simple
linear regression analysis was employed to assess the correlation between Vitamin D and HbA1c
levels. Gender-based differences were also explored within each Vitamin D and HbA1c
classification.
Results:
The ANOVA analysis revealed significant differences in HbA1c levels across Vitamin D groups (p
< 0.05). Pairwise comparisons indicated substantial variations between several groups. While a
weak correlation was found between Vitamin D and HbA1c levels (R Square = 0.044), subsequent
gender-specific analysis showed no significant differences within each Vitamin D and HbA1c
classification
.
Discussion:
The results highlight the impact of Vitamin D classifications on glycemic control, emphasizing the
importance of adequate Vitamin D levels in diabetes management. The weak correlation suggests
that while there is a connection between Vitamin D and HbA1c, other factors likely contribute to
glycemic fluctuations. Gender, however, does not seem to influence this relationship significantly,
ensuring the consistency of findings across both male and female participants.
Conclusion: This study underscores the intricate interplay between Vitamin D, HbA1c levels, and
glycemic situations. While Vitamin D exerts a subtle influence on glycemic control, its impact is
modulated by various factors yet to be explored fully. Understanding these complexities is vital for
developing personalized strategies in diabetes care
References
Singh D. Role of vitamins in the metabolic syndrome. Metab Syndr Diet Suppl Food Ingredients. 2023; :
–98. doi: 10.1201/9781003329732-9.
Xiao Y, Wei L, Xiong X, Yang M, Sun L. Association Between Vitamin D Status and Diabetic
Complications in Patients With Type 2 Diabetes Mellitus: A Cross-Sectional Study in Hunan China. Front
Endocrinol (Lausanne). 2020; 11. doi: 10.3389/fendo.2020.564738.
Danese E, Pucci M, Montagnana M, Lippi G. Vitamin D deficiency and pregnancy disorders. J Lab
Precis Med. 2020; 5: 5–5. doi: 10.21037/jlpm.2019.11.03.
Starska-Kowarska K. Role of Vitamin D in Head and Neck Cancer—Immune Function, Anti-Tumour
Effect, and Its Impact on Patient Prognosis. Nutrients. 2023. doi: 10.3390/nu15112592.
Diabetes DOF. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009; 32. doi:
2337/dc09-S062.
Sudhir Chandra Jha, Himanshu Kumar, Syed Yousuf Faisal. Correlation between Vitamin D and HbA1c
in Type 2 Diabetic Patients. Acad J Med. 2020; 3: 4–10. doi: 10.47008/ajm.2020.3.1.2.
Kim D. The role of vitamin D in thyroid diseases. Int J Mol Sci. 2017; 18: 1–19. doi:
3390/ijms18091949.
Dal Canto E, Ceriello A, Rydén L, Ferrini M, Hansen TB, Schnell O, Standl E, Beulens JWJ. Diabetes as
a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. Eur J Prev
Cardiol. 2019; 26: 25–32. doi: 10.1177/2047487319878371.
Nair R, Maseeh A. Vitamin D: The sunshine vitamin. J Pharmacol Pharmacother. 2012; 3: 118–26. doi:
4103/0976-500X.95506.
Matthias Wacker and, Michaela F. Holick. Sunlight and Vitamin D - A global perspective for health.
Dermatoendocrinol. 2013; 5: 211–7.
Abugoukh TM, Al Sharaby A, Elshaikh AO, Joda M, Madni A, Ahmed I, Abdalla RS, Ahmed K, Elazrag
SE, Abdelrahman N. Does Vitamin D Have a Role in Diabetes? Cureus. 2022; 25: 1–6. doi:
7759/cureus.30432.
Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. J Biomed Biotechnol. 2012;
doi: 10.1155/2012/634195.
Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V. The Possible Role of
Thi-Qar Medical Journal (TQMJ):Vol.( 26),No.(2),2023
Web Site: https://jmed.utq.edu Email: utjmed@utq.edu.iq
ISSN (Print):1992-9218
Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients. medRxiv [Internet].
; 25: 2020.04.08.20058578. Available from
/2020.04.08.20058578v4.abstract
Rashidi H, Ghaderian SB, Shirinpour Z, Yazdanpanah L, Kaykhaei MA, Aleali AM, Latifi SM, Bazdar
M. The effect of vitamin d supplementation on insulin resistance and glycemic control in patients with type 2
diabetes. Int J Pharm Technol. 2016; 8: 11634–42.
Wolosowicz M, Lukaszuk B, Chabowski A. The causes of insulin resistance in type 1 diabetes mellitus:
Is there a place for quaternary prevention? Int J Environ Res Public Health. 2020; 17: 1–13. doi:
3390/ijerph17228651.
Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC. The insulin-related ovarian regulatory system in
health and disease. Endocr Rev. 1999; 20: 535–82. doi: 10.1210/edrv.20.4.0374.
Li M, Chi X, Wang Y, Setrerrahmane S, Xie W, Xu H. Trends in insulin resistance: insights into
mechanisms and therapeutic strategy. Signal Transduct Target Ther. Springer US; 2022; 7: 1–25. doi:
1038/s41392-022-01073-0.
Yousefi Rad E, Djalali M, Koohdani F, Saboor-Yaraghi AA, Eshraghian MR, Javanbakht MH, Saboori S,
Zarei M, Hosseinzadeh-Attar MJ. The effects of vitamin D supplementation on glucose control and insulin resistance in
patients with diabetes type 2: A randomized clinical trial study. Iran J Public Health. 2014; 43: 1651–6.
Walecka I. The Essential Role of microRNAs in Inflammatory and Autoimmune Skin Diseases — A Review. 2023; .
Ali KM, Ali AM, Tawfeeq HM, Figueredo GP, Rostam HM. Hypoalbuminemia in patients following
their recovery from severe coronavirus disease 2019. J Med Virol. 2021; 93: 4532–6. doi: 10.1002/jmv.27002.
Ali AM, Rostam HM, Fatah MH, Noori CM, Ali KM, Tawfeeq HM. Serum troponin, D-dimer, and CRP
level in severe coronavirus (COVID-19) patients. Immunity, Inflamm Dis. 2022; 10: 1–10. doi: 10.1002/iid3.582.
Ali KM, Rashid PMA, Ali AM, Tofiq AM, Salih GF, Dana OI, Rostam HM. Clinical outcomes and
phylogenetic analysis in reflection with three predominant clades of SARS-CoV-2 variants. Eur J Clin Invest.
; : 1–15. doi: 10.1111/eci.14004.
Ali AM, Abdlwahid RF, Ali KM, Mahmood KI, Rashid PMA, Rostam HM. The influence of SARSCoV-2 on male reproduction and men’s health. Eur J Clin Invest. 2023; : 1–11. doi: 10.1111/eci.14097.
Al Dossari KK, Ahmad G, Aljowair A, Alqahtani N, Shibrayn M Bin, Alshathri M, Alshehri D, Akhlaq
S, Hejab F Bin, Alqahtani A, Razzak HA. Association of vitamin d with glycemic control in Saudi patients with
type 2 diabetes: A retrospective chart review study in an emerging university hospital. J Clin Lab Anal. 2020; 34:
–7. doi: 10.1002/jcla.23048.
Abubaker S, Albasseet A, El-abd KA, Alandijani AA, Alendijani YA, Alkhenizan A. Association
Between Vitamin D Levels and Glycemic Control Among Adult Diabetic Patients in Riyadh, Saudi Arabia.
Cureus. 2022; 14. doi: 10.7759/cureus.25919.
Thi-Qar Medical Journal (TQMJ):Vol.( 26),No.(2),2023
Web Site: https://jmed.utq.edu Email: utjmed@utq.edu.iq
ISSN (Print):1992-9218
Contreras-Bolívar V, García-Fontana B, García-Fontana C, Muñoz-Torres M. Mechanisms involved in
the relationship between vitamin D and insulin resistance: impact on clinical practice. Nutrients. 2021; 13: 1–25.
doi: 10.3390/nu13103491.
Narayanan S, Gopikuttan R. The correlation of vitamin D with HOMA-IR and glycated hemoglobin in
type 2 diabetes mellitus patients. Baghdad J Biochem Appl Biol Sci. 2022; 3: 273–85. doi:
47419/bjbabs.v3i04.153.
Zhao H, Zhen Y, Wang Z, Qi L, Li Y, Ren L, Chen S. The relationship between vitamin D deficiency and
glycated hemoglobin levels in patients with type 2 diabetes mellitus. Diabetes, Metab Syndr Obes. 2020; 13:
–907. doi: 10.2147/DMSO.S275673.
Yakout S, Faqeeh F, Al-Attas O, Hussain SD, Al-Daghri NM. Patterns and associations of essential trace
elements (Cu, fe and zn) in saudi adults with varying levels of glycemia. Metabolites. 2021; 11. doi:
3390/metabo11050297.
Tong KPS, Green SJ, Ortiz J, Wu SC. Association between hemoglobin A1c, Vitamin C, and microbiome
in diabetic foot ulcers and intact skin: A cross-sectional study. Heal Sci Reports. 2022; 5. doi: 10.1002/hsr2.718.
Teotia, N., Singh, A., Kunwar, S., Kumari, S. and Rathore, B.S. Comparison of the levels of 25 (OH)
vitamin D3 in women with gestational diabetes mellitus and normoglycemic pregnant women. J Obstet Gynaecol
Res. 2021; 47: pp.3842-3848.
Marzooqi LA Al. Prevalence, Characteristics and Correlates of Prediabetes in Al Ain and Dubai, the
UAE: Cross Sectional Study prevalense prediabe... 2018; . Available from
https://scholarworks.uaeu.ac.ae/health_dissertations/1/
Yu L, Zhai Y, Shen S, Wane D. Association between Vitamin D and prediabetes: A PRISMA-compliant
meta-analysis. Med (United States). 2020; 99. doi: 10.1097/MD.0000000000019034.
Randhawa FA, Mustafa S, Khan DM, Hamid S. Effect of vitamin D supplementation on reduction in
levels of HbA1 in patients recently diagnosed with type 2 diabetes mellitus having asymptomatic vitamin D
deficiency. Pakistan J Med Sci. 2017; 33: 881–5. doi: 10.12669/pjms.334.12288.
Al Thani M, Sadoun E, Sofroniou A, Jayyousi A, Baagar KAM, Al Hammaq A, Vinodson B, Akram H, Bhatti
ZS, Nasser HS, Leventakou V. The effect of vitamin D supplementation on the glycemic control of pre-diabetic Qatari
patients in a randomized control trial. BMC Nutr. BMC Nutrition; 2019; 5: 1–10. doi: 10.1186/s40795-019-0311-x.
Saif-Elnasr M, Ibrahim IM, Alkady MM. Role of vitamin D on glycemic control and oxidative stress in
type 2 diabetes mellitus. J Res Med Sci. 2017; 22. doi: 10.4103/1735-1995.200278.
Farahmand MA, Daneshzad E, Fung TT, Zahidi F, Muhammadi M, Bellissimo N, Azadbakht L. What is
the impact of vitamin D supplementation on glycemic control in people with type-2 diabetes: a systematic review
and meta-analysis of randomized controlled trails. BMC Endocr Disord [Internet]. BioMed Central; 2023; 23: 1–
doi: 10.1186/s12902-022-01209-x
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