Role of T1 Weighted and Diffusion Weighted Magnetic Resonance imaging application in the diagnosis of osteoporosis in lumbar spine in postmenopausal women

  • Riyadh Adel Jaed Abdulazeez .B.Ch.B-F.I.B.M.S-RD- College of medicine/ ThiQar university
  • Raad H. Abed Tawfeeq M.B.Ch.B -D.M.R.D- F.I.B.M.S.-R.D - Yarmook teaching hospital
  • Firas Abdullah Noori M.B.Ch.B D.M.R.D- college of medicine / ThiQar university
Keywords: diffusion weighted magnetic resonance imaging, T1, osteoporosis


Background: Postmenopausal Osteoporosis is one of the most common causes of primary osteoporosis. For two decades, diffusion-weighted imaging (DWI) has been applied to the evaluation of intracranial diseases, but technical advancement make it possible to apply DWI measurements to extra cranial sites, including vertebral column.                                                         

Objective: Using diffusion-weighted MR imaging technology to determine the  DWI  and  ADC values of lumbar vertebral body  in  postmenopausal women  in correlation  with  the   DEXA  t-scores.

Patients and Methods: A cross sectional analytical studywas conducted at Al-Yarmouk Teaching hospital in Baghdad city. A total of 80 postmenopausal women, was recruited from subjects who underwent DEXA of the spine and categorized into three groups according to their t-score: Normal BMD, Osteopenia, and Osteoporosis. Then MRI study done for all of them including: T1, T2, DWI, and ADC value measurement.                                                                                                      

Results: The values ​​of ADC at L3 vertebra were (0.46 ± 0.098) × 10-3 mm2/s, (0.42 ± 0.084) × 10-3 mm2/s, and (0.39 ± 0.052) × 10-3 mm2/s for the three groups: the normal, osteopenic, osteoporotic respectively. The values ​​of the diffusion signal intensity values ​​at L3 vertebra were 134.5 ± 5.7 mm2/s, 112.7 + 3.4 mm2/s, 101.3 + 4.4 mm2/s respectively. There was a significant difference among the three groups in both diffusion and ADC measurement.                                    

Conclusion: Both diffusion and ADC values are significantly lower in subjects with postmenopausal osteoporosis. There is a significant positive relationship between T score that was determined by DEXA, and the ADC value.                                                                                          


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