Review Article: Oral Microbiota and it's Role in Dental Caries

Authors

  • Faten Naeem Abbas Microbiology Department / Medicine college/Thi-Qar university

Abstract

Abstract: The oral microbiomes, specifically, have a significant impact on an individual's
health. The oral cavity contains over 500 bacterial species from multiple phyla, which can exist
as either commensals or pathogens. Streptococcus mutans is recognized as a significant pathogen
in the development of dental caries through biofilm formation. The objective of this review is to
provide a comprehensive understanding of the role that S. mutans in the development of dental
caries.

References

Guerra F., Mazur M., Ndokaj A., Corridore D., La Torre G., Polimeni A., et al. Periodontitis

and the microbiome: a systematic review and meta-analysis. Minerva stomatologica. 2018; 67

(6): 250-8.

Graves D.T., Correa J. D., Silva T. A. The Oral Microbiota Is Modified by Systemic Diseases.

Journal of dental research. 2019; 98 (2): 148-56.

Gomez, A., Nelson, K.E. The oral microbiome of children: Development, disease, and

implications beyond oral health. Microb. Ecol. 2017;73 (2), 492–503.

Le Bars, P.; Matamoros, S.; Montassier, E.; Le Vacon, F.; Potel, G. Soueidan, A.; Jordana,

F. and de La Cochetière, M. The oral cavity microbiota: between health, oral disease, and

cancers of the aerodigestive tract. Can. J. Microbiol. 2017; 63: 475–492.

Duran-Pinedo A. E., Frias-Lopez J. Beyond microbial community composition: functional

activities of the oral microbiome in health and disease. Microbes and infection. 2015; 17 (7):

-16.

Zhang Y., Wang X., Li H., Ni C., Du Z., Yan F. Human oral microbiota and its modulation

for oral health. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018; 99:

-93.

Moon J. H., Lee J. H. Probing the diversity of healthy oral microbiome with bioinformatics

approaches. BMB reports. 2016; 49 (12): 662-70.

Mukherjee, C., Moyer, C.O., Steinkamp, H.M., Hashmi, S.B., Beall, C.J., Guo, X., Ni, A.,

Leys, E.J., Griffen, A.L. Acquisition of oral microbiota is driven by environment, not host

genetics. Microbiome. 2021.

Reynolds-Campbell, G.; Nicholson, A. and Camille-Ann. Oral Bacterial Infections Diagnosis

and Management. Dent Clin N Am 2017;61 (2017) 305–318.

Wade, W.G. Detection and culture of novel oral bacteria. Oral microbial ecology–current

research and new perspectives. Caister Academic Press, Norfolk. 2013.

Bowen, W.H. and Koo, H. Biology of Streptococcus mutans-derived Glucosyl-transferases:

role in extracellular matrix formation of cariogenic biofilms. Caries Research. 2011;45(1): 69-86.

Kurtović, A.; Talapko, J.; Bekić, S. and Škrlec, I. The Relationship between Sleep,

Chronotype, and Dental Caries—A Narrative ReviewClocks Sleep. 2023; 5(2): 295–312.

Atkinson, F.S.; Khan, J.H.; Brand-Miller, J.C.; Eberhard, J. The Impact of Carbohydrate

Quality on Dental Plaque pH: Does the Glycemic Index of Starchy Foods Matter for Dental

Health? Nutrients 2021, 13, 2711.

Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, Tagami J,

Twetman S, Tsakos G, Ismail A. Dental caries. Nat Rev Dis Primers. 2017 May 25;3:17030.

A. Tanner, C.A. Kressirer, S. Rothmiller, I. Johansson, N.I. Chalm.The caries microbiome:

implications for reversing dysbiosisers. Adv. Dent. Res., 2018; 29 (1) 78-85.

Filoche S, Wong L, Sissons C. Critical reviews in oral biology and medicine: oral biofilms:

emerging concepts in microbial ecology. J Dent Res. 2010;89:8–18.

Rosier B. T., Marsh P. D., Mira A. Resilience of the Oral Microbiota in Health:

Mechanisms.That Prevent Dysbiosis. Journal of dental research. 2018; 97 (4): 371-80.

Kumar P. S., Mason M. R. Mouthguards: does the indigenous microbiome play a role in

maintaining oral health? Frontiers in cellular and infection microbiology. 2015; 5: 35.

Huang R., Li M., Gregory R. L. Bacterial interactions in dental biofilm. Virulence. 2011; 2

(5): 435-44.

Marsh P.D. In Sickness and in Health-What Does the Oral Microbiome Mean to Us? An

Ecological Perspective. Advances in dental research. 2018; 29 (1): 60-5.

Takahashi N. Oral Microbiome Metabolism: From "Who Are They?" to "What Are They

Doing?". Journal of dental research. 2015; 94 (12): 1628-37.

Palmer R. J., Jr. Composition and development of oral bacterial communities.

Periodontology 2000. 2014; 64 (1): 20-39.

Patini R., Staderini E., Lajolo C., Lopetuso L., Mohammed H., Rimondini L., et al.

Relationship between oral microbiota and periodontal disease: a systematic review. European

review for medical and pharmacological sciences. 2018; 22 (18): 5775-88.

Samaranayake L., Matsubara V. H. Normal Oral Flora and the Oral Ecosystem. Dental

clinics of North America. 2017; 61 (2): 199-215.

Kilian M., Chapple I. L., Hannig M., Marsh P. D., Meuric V., Pedersen A. M., et al. The oral

microbiome - an update for oral healthcare professionals. British dental journal. 2016; 221 (10):

-66.

Abranches , J; Zeng, L; Kajfasz, JK; Palmer, SR; Chakraborty, B; Wen, ZT; Richards, VP;

Brady, LJ and Lemos, JA. Biology of Oral Streptococci Microbiol, 2018; 6(5):

Krzysciak, W.; Pluskwa, K.K.; Jurczak, A.; Koscielniak, D. The pathogenicity of the

streptococcus genus. Eur. J. Clin. Microbiol. Infect. Dis., 2013;32, 1361–1376.

Richards, V.P.; Palmer, S.R.; Pavinski Bitar, P.D.; Qin, X.; Weinstock, G.M.; Highlander,

S.K.; Town, C.D.; Burne, R.A.; Stanhope, M.J. Phylogenomics and the dynamic genome

evolution of the genus streptococcus. Genome Biol. Evol. 2014, 6, 741–753.

Zhu, B., Macleod, L. C., Kitten, T., and Xu, P. Streptococcus sanguinis biofilm formation &

interaction with oral pathogens. Future Microbiol. 2018;13, 915–932.

Lannes-Costa, P.S.; de Oliveira, J.S.S.; da Silva Santos, G.; Nagao, P.E. A current review of

pathogenicity determinants of Streptococcus sp..Applied microbiology J. 2021; 131(4): 1600-

Brady, L.J.; Maddocks, S.E.; Larson, M.R.; Forsgren, N.; Persson, K.; Deivanayagam, C.C.;

Jenkinson, H.F. The changing faces of streptococcus antigen i/ii polypeptide family adhesins.

Mol. Microbiol. 2010, 77, 276–286.

Russell, R. Pathogenesis of oral streptococci. Gram-Positive and Pat- hogens Fischetti VA,

Novick RP, Ferretti JJ, Portnoy DA Rool JI, eds. American Society for Microbiology ،

Washington, DC; 2000; pp. 272–279

Krzyściak,W.; Pluskwa,K.K.; Piątkowski,J.; Krzyściak,P.; Jurczak,A.; Kościelniak,D. and

Skalniak,A The usefulness of biotyping in the determination of selected pathogenicity

determinants in Streptococcus mutans. BMC Microbiology, 2014;14:194.

Chun,S.;Huh, H.J. and Lee, N.Y. Species-Specific Difference in Antimicrobial

Susceptibility Among Viridans Group Streptococci. Ann of Lab Med., 2015;35 (2) : 205-11.

Huang,S.C.;Burne,R.A. and Chen,Y.MThe pH-Dependent Expression of the Urease Operon

in Streptococcus salivarius Is Mediated by CodY. Appl and Environmental Mic,

;80(17):5386-5393..

Ouennane, S. ; Leprohon, P. and Moineau, S. Diverse Virulent Pneumophages Infect

Streptococcus mitis. PLOS ONE, 2015;10(2): 0118807.

Alissa L. Villhauer, David J. Lynch 1, David R. Drake.Improved method for rapid and

accurate isolation and identification of Streptococcus mutans and Streptococcus sobrinus from

human plaque samples; Journal of Microbiological Methods Volume 139, August 2017, Pages

-209.

Saravia , M E.; Nelson-Filho ;P.; Ito I Y.; da Silva L A B; da Silva R A B and

Emilson, C. Morphological differentiation between S. mutans and S. sobrinus on modified SB20 culture medium Microbiol. Res. (2011)

Yousefi, B.; Ghaderi, S.; Rezapoor-Lactooyi, A.; Amiri, N.; Verdi, J.; Shoae-Hassani, A.

Hydroxy decenoic acid down regulates gtfB and gtfC expression and prevents Streptococcus

mutans adherence to the cell surfaces. Annals of Clinical Microbiology and Antimicrobials 2012,

, 21.

Yousefi, L.; Leylabadlo, H.E.; Pourlak, T.; Eslami, H.; Taghizadeh, S.; Ganbarov, K.;

Yousefi, M.; Tanomand, A.; Yousefi, B.; Kafil, H.S. Oral spirochetes: Pathogenic mechanisms

in periodontal disease. Microbial Pathogenesis 2020, 144, 104193.

van de Lagemaat, M.; Stockbroekx, V.; Geertsema-Doornbusch, G.I.; Dijk, M.; Carniello,

V.; Woudstra, W.; van der Mei, H.C.; Busscher, H.J.; Ren, Y. A Comparison of the Adaptive

Response of Staphylococcus aureus vs. Streptococcus mutans and the Development of

Chlorhexidine Resistance. Front Microbiol.2022, 13, 861890.

Tahmourespour, A.; Aminzadeh, A.; Salehifard, I. Anti-adherence and antibacterial activities

of Pistacia atlantica resin extract against strongly adherent Streptococcus mutans strains. Dent

Res J. 2022, 19, 36,

Ferrando, M.; Coghe, F.; Scano, A.; Carta, M.G.; Orru, G. Co-infection of Streptococcus

pneumoniae in Respiratory infections Caused by SARS-CoV-2. Biointerface Research in

Applied Chemistry 2021, 11, 12170-12177.

Rezaei, T.; Mehramouz , B. ; Gholizadeh, P.; Yousefi, L.; Ganbarov K .; Ghotaslou, R.;

Taghizadeh, S. and Kafil, H. S. Factors Associated with Streptococcus mutans Pathogenicity in

the Oral Cavity . Biointerfaceresearch, 2023; 13( 4):368.

Ayi, B. Viridans-Induced Infections. The book "Streptococci: The Comprehensive

Pharmacology Reference" was published in 2007.

Matsumoto-Nakano, M.(2018). Role of Streptococcus mutans surface proteins for biofilm

formation. Japanese Dental Science Review 2018, 54(1):22-29,

Hudson, M. C. and Curtiss, R. Regulation of Expression of Streptococcus mutans genes

important to virulence, infection and immunity(1990), 58(2):p. 464-470.

Chismirina, S.; Sungkar, S.; Andayani, R.; Rezeki, S. Darmawi. Existence of Streptococcus

Mutans and Streptococcus Sobrinus in Oral Cavity as Main Cariogenc Bacteria of Dental Caries.

Advances in Health Sciences Research, (2021)volume 32

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Published

2024-04-28

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