Prevalence of Cutaneous Warts Caused by Human Papillomaviruses and the Effect of Vitamin D with it's Distribution Among Patients in Thi-Qar Province

Authors

  • Haider Nasser Mahdi Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar 64001
  • Mohammed Jasim Mohammed Shallal Department of Microbiology, College of Medicine, University of Thi-Qar, Thi-Qar 64001
  • Alaa A. Naif Department of Dermatology, College of Medicine, University of Thi-Qar, 64001, Iraq

Keywords:

Cutaneous warts, HPV (Human Papillomavirus), Vitamin-D

Abstract

Background: Cutaneous warts represent prevalent skin lesions resulting from infection with
human papillomavirus (HPV) (Sterling et al., 2014). HPV, a diverse group of viruses capable
of infecting both skin and mucous membranes, can give rise to various conditions, prominently
including the development of warts. With over 100 distinct HPV types identified, the
association between specific strains and the manifestation of distinct wart types is wellestablished (Bernard et al., 2010).
Cutaneous warts are skin infection characterized by skin growths that high and rough. appear
in numerous regions of the body, most commonly on the hands, feet, and faces (Shallal et al.,
2023). warts caused by Human papillomavirus (HPV). According to previous studies there
are possible link between serum vitamin D insufficiency with developing of cutaneous warts
(Mahmoud & Ayyash, 2021). investigation of vitamin D aim in verifying the existence of a
relationship between vitamin D and the occurrence of cutaneous warts.
Aim: The aim of this study is to Investigate the serum levels of vitamin D in patients related
to the presence of cutaneous warts caused by human papillomavirus and in compared to healthy
individuals.
Methods: Between October 2023 and December 2023, this research involved gathering
serum samples from 103 individuals diagnosed with cutaneous warts. Additionally, a control
group comprising 50 individuals of various ages without warts was included. The
determination of serum vitamin D levels was conducted using the electrochemiluminescence
(ECL) method

References

Aktaş, H., Ergin, C., Demir, B., & Ekiz, Ö. Intralesional vitamin D injection may be an

effective treatment option for warts. Journal of Cutaneous Medicine and Surgery, 2016: 20 (2),

-122.

Bernard HU, Burk RD, Chen Z, van Doorslaer K, zur Hausen H, de Villiers EM. Classification

of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments.

: Virology. 10;401(1):70-9.

Bikle, D. D. Vitamin D and the immune system: role in protection against bacterial infection.

Curr Opin Nephrol Hypertens, 2008: 17(4), 348-352.

Bzhalava, D., Guan, P., Franceschi, S., Dillner, J., & Clifford, G. A systematic review of the

prevalence of mucosal and cutaneous human papillomavirus types. Virology, 2013: 445 (1-2),

-231.

Chen, Y., Zhang, J., Ge, X., Du, J., Deb, D. K., & Li, Y. C. Vitamin D receptor inhibits nuclear

factor κB activation by interacting with IκB kinase β protein. J Biol Chem, 2013: 288 (27),

-19458.

Dogan, S., Primorac, D., & Marjanović, D. Genetic analysis of haplotype data for 23 Ychromosome short tandem repeat loci in the Turkish population recently settled in Sarajevo,

Bosnia and Herzegovina. Croatian Medical Journal, 2014: 55 (5), 530.

El Mongy, N. N., Hilal, R. F., Badr, A. M., & Alraawi, S. A.. Serum vitamin D level in patients

with viral warts. Journal of the Egyptian Women's Dermatologic Society, 2018: 15(3), 133138.

ERTUĞRUL, G., & AKTAŞ, H. (2022). Serum 25-Hydroxy Vitamin D Level Does Not

Reflect The Severity of Wart: A Cross-Sectional Study. Kahramanmaraş Sütçü İmam

Üniversitesi Tıp Fakültesi Dergisi, 17(2), 15-19.

Goodarzi, A., Farshidzadeh, M., Roohaninasab, M., Atefi, N., & Behrangi, E. (2020).

Assessment of serum vitamin D level in patients with cutaneous warts: a case-control study.

Iranian Journal of Dermatology, 23(2), 64-71.

Green, R. J., Samy, G., Miqdady, M., El-Hodhod, M., Akinyinka, O., Saleh, G., Haddad, J.,

Alsaedi, S., Mersal, A., & Edris, A. (2015). Vitamin D deficiency and insufficiency in Africa

and the Middle East, despite year-round sunny days. SAMJ: South African Medical Journal,

(7), 603-605.

Jakhar, D., Kaur, I., & Misri, R. (2019). Intralesional vitamin D3 in periungual warts. Journal

of the American Academy of Dermatology, 80 (5), e111-e112.

Johnson, M.-L. T., & Roberts, J. (1978). Skin conditions and related need for medical care

among persons 1-74 years, United States, 1971-1974. Department of Health, Education, and

Welfare, Public Health Service, Office ….

Juzeniene, A., Ma, L. W., Kwitniewski, M., Polev, G. A., Lagunova, Z., Dahlback, A., &

Moan, J. (2010). The seasonality of pandemic and non-pandemic influenzas: the roles of solar

radiation and vitamin D. Int J Infect Dis, 14(12), e1099-1105.

Kanwal, S., ur Rehman, F., Fatima, B., Qureshi, S. W., Jamil, S., & Khan, R. N. (2023).

Evaluation of Serum Vitamin D Levels Among Patients with Viral Warts. Pakistan Armed

Forces Medical Journal, 73(2), 402-404.

Kasim, K., Amer, S., Mosaad, M., Abdel-Wahed, A., & Allam, H. (2013). Some epidemiologic

aspects of common warts in rural primary school children. International Scholarly Research

Notices, 2013.

Kavya, M., Shashikumar, B. M., Harish, M. R., & Shweta, B. P. (2017). Safety and efficacy

of intralesional vitamin D3 in cutaneous warts: An open uncontrolled trial. Journal of

cutaneous and aesthetic surgery, 10(2), 90.

Khalili, S. M., Rafiei, E. H., Havaei, M., Alizadeh, L., Ghahremani, F., Keshavarz, Z.,

Montazeri, A., & Riazi, H. (2024). Relationship between human papillomavirus and serum

vitamin D levels: a systematic review. BMC Infectious Diseases, 24(1), 1-8.

Liu, J., Li, H., Yang, F., Ren, Y., Xia, T., Zhao, Z., Cao, X., Wang, Z., Yin, M., & Lu, S.

(2018). Epidemiology and clinical profile of cutaneous warts in Chinese college students: a

cross-sectional and follow-up study. Scientific reports, 8(1), 15450.

Mahmoud, R. T. I., & Ayyash, M. H. (2021). Common warts treatment by intralesional (60,000

versus 120,000) IU of vitamin D3, comparative study. Prof.(Dr) RK Sharma, 21(1), 853.

Mertoğlu, C., Nayki, Ü., Nayki, C., & Gunay, M. (2017). The relationship between vitamin D

and human papilloma virus infection. JOURNAL OF CLINICAL AND ANALYTICAL

MEDICINE, 8(6).

Mirhosseini, N., Rainsbury, J., & Kimball, S. M. (2018). Vitamin D Supplementation, Serum

(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and

Meta-Analysis. Front Cardiovasc Med, 5, 87.

Moscarelli, L., Annunziata, F., Mjeshtri, A., Paudice, N., Tsalouchos, A., Zanazzi, M., &

Bertoni, E. (2011). Successful treatment of refractory wart with a topical activated vitamin D

in a renal transplant recipient. Case Reports in Transplantation, 2011.

Prakash, R. B., Balachandrudu, J., & Reddy, P. P. (2019). CLINICO-EPIDEMIOLOGICAL

STUDY OF WARTS IN A TERTIARY CARE HOSPITAL. Journal of Evolution of Medical

and Dental Sciences, 8(16), 1258-1262.

R Sanad, R., M Sanad, E., M Hamed, A., & K Shahat, A. (2023). Assessment of Response to

Intralesional Vitamin D in Treatment of Warts. Benha Journal of Applied Sciences, 8(3), 7881.

Raghukumar, S., Ravikumar, B., Vinay, K., Suresh, M., Aggarwal, A., & Yashovardhana, D.

(2017). Intralesional vitamin D3 injection in the treatment of recalcitrant warts: a novel

proposition. Journal of Cutaneous Medicine and Surgery, 21(4), 320-324.

Shalaby, M. E., Hasan, M. S., Elshorbagy, M. S., Abo Raya, A. R., & Elsaie, M. L. (2022).

Diagnostic and therapeutic implications of vitamin D deficiency in patients with warts: a case‐

controlled study. Journal of Cosmetic Dermatology, 21(3), 1135-1142.

Shallal, M. J. M., Madlool, S. W., & Naif, A. A. (2023). Molecular Detection of Cutaneous

Warts Among Male and Female Patients in Thi-Qar Province. University of Thi-Qar Journal

Of Medicine, 25(1), 39-50.

Shim, J., Pérez, A., Symanski, E., & Nyitray, A. G. (2016). Association Between Serum 25-

Hydroxyvitamin D Level and Human Papillomavirus Cervicovaginal Infection in Women in

the United States. J Infect Dis, 213(12), 1886-1892.

Silverberg, J. I., & Silverberg, N. B. (2013). The US prevalence of common warts in childhood:

a population-based study. The Journal of Investigative Dermatology, 133(12), 2788.

Sterling, J. C., Gibbs, S., Haque Hussain, S. S., Mohd Mustapa, M. F., & Handfield-Jones, S.

E. (2014). British Association of Dermatologists' guidelines for the management of cutaneous

warts 2014. Br J Dermatol, 171(4), 696-712.

Tamer, F., Eren Yuksel, M., & Karabag, Y. (2020). Pre-treatment vitamin B12, folate, ferritin,

and vitamin D serum levels in patients with warts: a retrospective study. Croatian Medical

Journal, 61(6), 28-32.

Thappa, D. M., & Chiramel, M. J. (2016). Evolving role of immunotherapy in the treatment of

refractory warts. Indian Dermatol Online J, 7(5), 364-370.

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2024-04-28

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