The Role of Vitamin D in Cardiovascular Health-Linked Adipose Tissue

Authors

  • Hussain Ahmed Shamkhi Department of Biochemistry, College of Medicine, University of Thi Qar, Iraq

Keywords:

cardiovascular, Vitamin D, Adipose tissue

Abstract

The rapid increase in the prevalence of cardiovascular diseases and low vitamin D levels are both
considered important public health issues. low level of vitamin D can promote endothelial dysfunction
and the development of atherosclerosis. also Vitamin D receptors are also expressed in the
cardiomyocytes of the left ventricle. One of the important mechanisms by which vitamin D affects
cardiovascular health is its effect on adipose tissue. Vitamin D can modulate the inflammatory response
of immune cells and adipocytes inside adipose tissue. Given the importance of vitamin D levels and
their relationship to adipose tissue in people with cardiovascular disease, understanding the mechanisms
of action of vitamin D in adipocytes may have a significant impact on maintaining cardiovascular health.
In the present review, we focus on mechanisms through which vitamin D may influence adipose tissue
associated with cardiovascular disease. In addition to checking whether vitamin D supplementation can
be a treatment option to improve adipose tissue function and thus prevent cardiovascular disease

References

-Sadeghi M, Haghdoost AA, Bahrampour A, Dehghani M. Modeling the burden of cardiovascular

diseases in Iran from 2005 to 2025: the impact of demographic changes. Iran J Public Health.

;46(4):506

-GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality

for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global

Burden of Disease Study 2017. Lancet 2018;392:1736–88.

- Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030.

PLoS Med. 2006;3(11):e442.

-Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2019 (GBD 2019)

Results. Seattle, WA: Institute for Health Metrics and Evaluation (IHME); 2020.

- Mohammad AA, Rashad HH, Habeeb QS, Rashad BH and Saeed SY. Demographic, clinical and

angiographic profile of coronary artery disease in Kurdistan Region of Iraq. Am J Cardiovasc Dis. 2021;

(1): 39-45.

-Mendis S, Puska P, Norrving B, Organization WH. Global atlas on cardiovascular disease prevention

and control. Geneva: World Health Organization; 2011.

- Ofori EK, Intifu FD, Asante M, Asare GA, Adjei PK, Steele-Dadzie RK, et al. Prevalence of

cardiovascular disease risk factors among students of a tertiary institution in Ghana. Food Sci Nutr.

; 6: 381-387.

-Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, Abrishami M, Juya M, Khodaee G, et al.

Atherogenic index of plasma (AIP): a marker of cardiovascular disease. Med J Islam Repub Iran.

;29:240.

- Ordovas JM. Genetic interactions with diet influence the risk of cardiovascular disease. Am J Clin

Nutr. 2006;83(2):443S–6S.

- Martirosyan DM, Miroshnichenko LA, Kulakova SN, Pogojeva AV, Zoloedov VI. Amaranth oil

application for coronary heart disease and hypertension. Lipids Health Dis. 2007;6(1):1.

- Després J-P, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881.

- Pengpid S and Peltzer K. Overweight and Obesity among Adults in Iraq: Prevalence and Correlates

from a National Survey in 2015. Int. J. Environ. Res. Public Health 2021; 18, 4198.

- Cortese, F., Costantino, M.F., Luzi, G. et al. Vitamin D and cardiovascular disease risk. A literature

overview. Mol Biol Rep 49, 8925–8942 (2022).

-Kheiri, B., Abdalla, A., Osman, M. et al. Vitamin D deficiency and risk of cardiovascular diseases: a

narrative review. Clin Hypertens 24, 9 (2018).

-Holick, M.F. Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We

Need? Adv. Exp. Med. Biol. 2020, 1268, 19–36.

-Mawer, E.B.; Backhouse, J.; Holman, C.A.; Lumb, G.A.; Stanbury, S.W. The distribution and

storage of vitamin D and its metabolites in human tissues. Clin. Sci. 1972, 43, 413–431.

- Latic, N.; Erben, R.G. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension,

atherosclerosis, and Heart Failure. Int. J. Mol. Sci. 2020, 21, 6483.

-Institute of Medicine. Dietary Reference Intakes: Calcium and Vitamin D; National Academies

Press: Washington, DC, USA, 2011.

- Pilz, S.; Zittermann, A.; Trummer, C.; Theiler-Schwetz, V.; Lerchbaum, E.; Keppel, M.H.; Grübler,

M.R.; März, W.; Pandis, M. Vitamin D testing and treatment: A narrative review of current

evidence. Endocr. Connect. 2019, 8, R27–R43.

Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D,

Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C,

Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P,

Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W. Global

Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol

Metab 2016;101:394-415. Epub 2016 Jan 8

-EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). Scientific opinion on

dietary reference values for vitamin D. EFSA J. 2016, 14, 4547.

-DGE (German Nutrition Society), Österreichische Gesellschaft für Ernährung, Schweizerische

Gesellschaft für Ernährungsforschung, Schweizerische Vereinigung für Ernährung. D-A-CH

Referenzwerte für die Nährstoffzufuhr, 1st ed.; 5. korrigierter Nachdruck 2013; Neuer Umschau

Buchverlag: Neustadt an der Weinstraße, Germany, 2012.

-Nordic Council of Ministers. Nordic Nutrition Recommendations 2012, 5th ed.; Narayana Press:

Odder, Denmark, 2014.

-Nair R, Maseeh A. Vitamin D: The sunshine vitamin. J PharmacolPharmacother. 2012;3(2):118–26.

-Mohammed, Lina Y., et al. "The Prevalence of Vitamin D Deficiency and Associated Risk Factors

among General Populations in Duhok Province, Kurdistan Region, Iraq." J Contemp Med Sci| Vol 7.6

(2021): 330-333.

- A. M. Issa and S. A. Ibraheem, “Alterations of Vitamin “D” level in Sera of Iraqi Population,”

Journal of Kerbala University, vol. 5, no. 1, pp. 58-64, 2007].

-Mahdi M, Hantoosh H, Imran B, Yahya A. Prevalence of vitamin D deficiency in Iraqi female at

reproductive age. Medical Journal of Babylon.; 16(2) (2019

-Al-Alyani H, Al-Turki HA, Al-Essa ON, Alani FM, Sadat-Ali M. Vitamin D deficiency in Saudi

Arabians: A reality or simply hype: A meta-analysis (2008-2015). J Family Community Med.; 25(1):1-4

(2018).

- Hussein, Ibrahim Hani, et al. "Real-Life Data on Total Vitamin D3 (25-Hydroxyvitamin D)

Concentrations in Basrah, Iraq." Biomedical & Pharmacology Journal 14.4 (2021): 2191-2198.

-Hassan-Smith, Zaki K., Martin Hewison, and Neil J. Gittoes. "Effect of vitamin D deficiency in

developed countries." British medical bulletin 122.1 (2017): 79-89.

- Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, et al.

Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort

and randomised intervention studies. BMJ. (2014) 348:g1903. doi: 10.1136/bmj.g1903

- Gouni-Berthold, Ioanna, and Heiner K. Berthold. "Vitamin D and vascular disease." Current

vascular pharmacology 19.3 (2021): 250-268.

-Latic, N.; Erben, R.G. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension,

atherosclerosis, and Heart Failure. Int. J. Mol. Sci. 2020, 21, 6483.

-Norman, P.E.; Powell, J.T. Vitamin D and cardiovascular disease. Circ. Res. 2014, 114, 379–393.

-Condoleo, V.; Pelaia, C.; Armentaro, G.; Severini, G.; Clausi, E.; Cassano, V.; Miceli, S.; Fiorentino,

T.V.; Succurro, E.; Arturi, F.; et al. Role of Vitamin D in Cardiovascular Diseases. Endocrines 2021, 2,

-426.

-Chen, S.; Glenn, D.J.; Ni, W.; Grigsby, C.L.; Olsen, K.; Nishimoto, M.; Law, C.S.; Gardner, D.G.

Expression of the vitamin D receptor is increased in the hypertrophic heart. Hypertension 2008, 52,

–1112.

- Zittermann, A.; Schleithoff, S.S.; Tenderich, G.; Berthold, H.K.; Körfer, R.; Stehle, P. Low vitamin

D status: A contributing factor in the pathogenesis of congestive heart failure? J. Am. Coll. Cardiol.

, 41, 105–112.

-Chanakul, A.; Zhang, M.Y.H.; Louw, A.; Armbrecht, H.J.; Miller, W.L.; Portale, A.A.; Perwad, F.

FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues. PLoS ONE 2013, 8,

e72816.

-Somjen, D.; Weisman, Y.; Kohen, F.; Gayer, B.; Limor, R.; Sharon, O.; Jaccard, N.; Knoll, E.; Stern,

N. 25-Hydroxyvitamin D3-1-Hydroxylase Is Expressed in Human Vascular Smooth Muscle Cells and Is

Upregulated by Parathyroid Hormone and Estrogenic Compounds. Circulation 2005, 111, 1666–1671.

-Scialla, J.J.; Wolf, M. Roles of phosphate and fibroblast growth factor 23 in cardiovascular disease.

Nat. Rev. Nephrol. 2014, 10, 268–278.

-Schmidt, N.; Brandsch, C.; Kühne, H.; Thiele, A.; Hirche, F.; Stangl, G.I. Vitamin D receptor

deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in

mice. PLoS ONE 2012, 7, e35316

-Schmidt, N.; Brandsch, C.; Schutkowski, A.; Hirche, F.; Stangl, G.I. Dietary vitamin D inadequacy

accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor

knockout and wild-type mice. J. Nutr. 2014, 144, 638–646.

Mutt SJ, Hyppönen E, Saarnio J, Järvelin MR, Herzig KH. Vitamin D and adipose tissue-more than

storage. Front Physiol 2014;5:228.

- Nimitphong, Hataikarn, Eunmi Park, and Mi-Jeong Lee. "Vitamin D regulation of adipogenesis and

adipose tissue functions." Nutrition research and practice 14.6 (2020): 553.

-Park, C.Y.; Han, S.N. The role of vitamin D in adipose tissue biology: Adipocyte differentiation,

energy metabolism, and inflammation. J. Lipid Atheroscler. 2021, 10, 130.

-Yuzbashian, E.; Asghari, G.; Hedayati, M.; Zarkesh, M.; Mirmiran, P.; Khalaj, A. Determinants of

vitamin D receptor gene expression in visceral and subcutaneous adipose tissue in non-obese, obese, and

morbidly obese subjects. J. Steroid Biochem. Mol. Biol. 2019, 187, 82–87.

-Rosenstreich, S.J.; Rich, C.; Volwiler, W. Deposition in and release of vitamin D 3 from body fat:

Evidence for a storage site in the rat. J. Clin. Investig. 1971, 50, 679–687.

Clemente-Postigo M, Muñoz-Garach A, Serrano M, Garrido-Sánchez L, Bernal-López MR,

Fernández-García D, Moreno-Santos I, Garriga N, Castellano-Castillo D, Camargo A, Fernández-Real

JM, Cardona F, Tinahones FJ, Macías-González M. Serum 25-hydroxyvitamin D and adipose tissue

vitamin D receptor gene expression: relationship with obesity and type 2 diabetes. J Clin Endocrinol

Metab 2015;100:E591-5.

- Płudowski, P.; Kos-Kudła, B.; Walczak, M.; Fal, A.; Zozulińska-Ziółkiewicz, D.; Sieroszewski, P.;

Peregud-Pogorzelski, J.; Lauterbach, R.; Targowski, T.; Lewiński, A. Guidelines for preventing and

treating vitamin D deficiency: A 2023 update in Poland. Nutrients 2023, 15, 695.

-Szymczak-Pajor, I.; Miazek, K.; Selmi, A.; Balcerczyk, A.; Śliwińska, A. The action of vitamin D in

adipose tissue: Is there the link between vitamin D deficiency and adipose tissue-related metabolic

disorders? Int. J. Mol. Sci. 2022, 23, 956.

-Gangloff, A.; Bergeron, J.; Lemieux, I.; Després, J.-P. Changes in circulating vitamin D levels with

loss of adipose tissue. Curr. Opin. Clin. Nutr. Metab. Care 2016, 19, 464–470.

-Didriksen, A.; Burild, A.; Jakobsen, J.; Fuskevåg, O.M.; Jorde, R. Vitamin D3 increases in

abdominal subcutaneous fat tissue after supplementation with vitamin D3. Eur. J. Endocrinol. 2015, 172,

–241.

-Martinaityte, I.; Kamycheva, E.; Didriksen, A.; Jakobsen, J.; Jorde, R. Vitamin D stored in fat tissue

during a 5-year intervention affects serum 25-hydroxyvitamin D levels the following year. J. Clin.

Endocrinol. Metab. 2017, 102, 3731–3738.

-da Silva, E.M.S.; Pinho, H.S.; Rodrigues, I.G.; Pinho, C.P.S. Asociación entre los niveles séricos de

vitamina D y las alteraciones cardiometabólicas. Nutr. Clínica Dietética Hosp. 2019, 39, 86–93.

-da Silva, S.; Maria, E.; Pinho; Sabino, H.; Rodrigues; Galvão1, I.; Pinho; Sabino, C.P. Association

between serum vitamin D levels and cardiometabolic alterations. Nutr. Clín. Diet. Hosp. 2019, 39, 86–

-Carrelli, A.; Bucovsky, M.; Horst, R.; Cremers, S.; Zhang, C.; Bessler, M.; Schrope, B.; Evanko, J.;

Blanco, J.; Silverberg, S.J. Vitamin D storage in adipose tissue of obese and normal weight women. J.

Bone Miner. Res. 2017, 32, 237–242.

-Wortsman, J.; Matsuoka, L.Y.; Chen, T.C.; Lu, Z.; Holick, M.F. Decreased bioavailability of vitamin

D in obesity. Am. J. Clin. Nutr. 2000, 72, 690–693.

-Hey, H.; Stokholm, K.; Lund, B.; Sørensen, O. Vitamin D deficiency in obese patients and changes

in circulating vitamin D metabolites following jejunoileal bypass. Int. J. Obes. 1982, 6, 473–479.

-de Souza, Wysllenny Nascimento, and Ligia Araujo Martini. "The role of Vitamin D in obesity and

inflammation at adipose tissue." J Obes Metab Res 2.3 (2015): 161.

- Ching S, Kashinkunti S, Niehaus MD, Zinser GM. Mammary adipocytes bioactivate 25

hydroxyvitamin D3 and signal via Vitamin D3 receptor, modulating mammary epithelial cell growth. J

Cell Biochem 2011;112:3393 405

-Park JE, Pichiah PBT, Cha YS. Vitamin D and Metabolic Diseases: Growing Roles of Vitamin D. J

Obes Metab Syndr. 2018 Dec;27(4):223-232. doi: 10.7570/jomes.2018.27.4.223. Epub 2018 Dec 30.

PMID: 31089567; PMCID: PMC6513299.

-Han TS, Lean ME. A clinical perspective of obesity, metabolic syndrome and cardiovascular disease.

JRSM Cardiovasc Dis. 2016;5:2048004016633371. doi:10.1177/2048004016633371.

- Soskić, Sanja, Edita Stokić, and Esma R. Isenović. "The relationship between vitamin D and

obesity." Current medical research and opinion 30.6 (2014): 1197-1199.

-Ouellet, V., Labbe´ , S.M., Blondin, D.P., Phoenix, S., Gue´ rin, B., Haman, F., Turcotte, E.E.,

Richard, D., and Carpentier, A.C. (2012). Brown adipose tissue oxidative metabolism contributes to

energy expenditure during acute cold exposure in humans. J. Clin. Invest. 122, 545–552.

- Szymczak-Pajor, I.; Miazek, K.; Selmi, A.; Balcerczyk, A.; Śliwińska, A. The Action of Vitamin D

in Adipose Tissue: Is There the Link between Vitamin D Deficiency and Adipose Tissue-Related

Metabolic Disorders? Int. J. Mol. Sci. 2022, 23, 956

- Chiang, Janet M; Stanczyk, F. Z. (2018). Vitamin D Levels, Body Composition, and Metabolic

Factors in Asian Indians: Results from the Metabolic Syndrome and Atherosclerosis in South Asians

Living in America Pilot Study. (Thesis).

- Ferira, Ashley Jordan. Vitamin D, insulin sensitivity, and cardiometabolic risk in children. Diss.

University of Georgia, 2011.

-Pelczynska M, Grzelak T, Walczak M, Czyzewska K. Hypovitaminosis D and adipose tissue—cause

and effect relationships in obesity. Ann Agric Environ Med. 2016;23(3):403–9. pmid:27660858.

-Ding C, Gao D, Wilding J, Trayhurn P, Bing C. Vitamin D signalling in adipose tissue. Br J Nutr.

;108(11):1915–23. pmid:23046765.

-Wamberg L, Christiansen T, Paulsen SK, Fisker S, Rask P, Rejnmark L, et al. Expression of vitamin

D-metabolizing enzymes in human adipose tissue—the effect of obesity and diet-induced weight loss.

Int J Obes (Lond). 2013;37(5):651–7. pmid:22828938.

-Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in

obesity. Am J Clin Nutr. 2000;72(3):690–3. pmid:10966885.

-Norman PE, Powell JT. Vitamin D and cardiovascular disease. Circ Res. 2014;114(2):379–93.

pmid:24436433.

- Moukayed, Meis, and William B. Grant. "Linking the metabolic syndrome and obesity with vitamin D status:

risks and opportunities for improving cardiometabolic health and well-being." Diabetes, Metabolic Syndrome and

Obesity: Targets and Therapy (2019): 1437-1447.

- Zittermann, Armin, et al. "Vitamin D and cardiovascular disease: an updated narrative review." International

journal of molecular sciences 22.6 (2021): 2896.

-Elkhwanky MS, Kummu O, Piltonen TT, et al. Obesity represses CYP2R1, the vitamin D 25-hydroxylase, in

the liver and extrahepatic tissues. JBMR Plus. 2020;4(11):e10397. doi:10.1002/jbm4.10397

-Tobias, Deirdre K., et al. "Association of body weight with response to vitamin D supplementation and

metabolism." JAMA Network Open 6.1 (2023): e2250681-e2250681

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2024-05-16

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