Effects of Multivitamin Supplementation on Liver Enzymes in Depressive Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial and Community Health Implications

Authors

  • Saman Muhammad Amin Said Ministry of Health, Garmian General Directorate of Health, KRG, Kalar, Ira
  • Hawal Lateef Fateh Nursing Department, Kalar Technical Institute, Garmian polytechnic university, Kalar, Iraq
  • Shahab Muhammad Rezaeian Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Serwan Muhammad Amin Said Assistant Teacher in Kalar Education Directorate

Keywords:

Non-alcoholic fatty liver disease, NAFLD, depression

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition commonly
observed in depressive patients.
Objective: this randomized clinical trial aimed to investigate the effects of multivitamin
supplementation on liver enzymes in depressive patients with NAFLD.
Methods: The study randomly divided the participants into two groups: the intervention group,
which received multivitamin supplementation, and the control group, which received a placebo.
The researchers examined liver enzymes such as alanine aminotransferase (ALT), aspartate
aminotransferase (AST), alkaline phosphatase (ALP), and serum bilirubin to evaluate liver
function. They conducted statistical analyses to compare the changes in the levels of these liver
enzymes between the two groups.
Results: The results demonstrated that the multivitamin supplementation group showed a
statistically significant decrease in ALT, AST, ALP and serum bilirubin levels compared to the
placebo group. Also results showed that the multivitamin supplementation group exhibited
significant improvements in depressive symptom scores compared to the placebo group.
Conclusion: The results of this study indicate that multivitamin supplementation could
potentially improve liver function in individuals with non-alcoholic fatty liver disease (NAFLD)
who also suffer from depression. However, additional research is needed to investigate the
underlying mechanisms and long-term impacts of multivitamin supplementation on liver health
specifically in this group of patients.

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Published

2024-10-21

Issue

Vol. 28 No. 2 (2024)

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ARTICLE

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