The Role of RBP4 in Insulin Resistance and Type 2 Diabetes Mellitus
Keywords:
insulin resistance, retinol binding protein 4 (RBP4), type 2 diabetes mellitus (T2DM)Abstract
Retinol is transported from the liver to peripheral tissues via the vitamin A transport protein whichknown as a retinol binding protein 4 (RBP4). According to several epidemiological studies, the
high concentrations of serum RBP4 are related to the risk of type 2 diabetes (T2DM) and insulin
resistance. Therefore, the aim of the current study was to assess the role of RBP4 in the insulin
resistance and type 2 diabetes. From August 2023 to December 2023, 100 participants who were
matched for age (30-70) years and sex (59 female- 41 male) participated in a case control study.
They divided into two groups: 50 patients with type 2 diabetes and 50 healthy individuals as a
control group. Enzyme-Linked Immunosorbent Assay was used to measure the serum RBP4.
According to results, RBP4 was considerably higher in patients with statistical significant (p
value˂0.001) compared to control group. This study was concluded that T2DM and insulin
resistance were substantially correlated to levels of serum RBP4.
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