Adiponectin as a Potential Biomarker in Acute Myocardial Infarction and Association with Renal Dysfunction
DOI:
https://doi.org/10.32792/jmed.2025.29.15Keywords:
Adiponectin, Acute Myocardial Infraction, Renal DysfunctionAbstract
Background: The association between serum adiponectin levels and acutemyocardial infarction, particularly how adiponectin predicts the development of
acute myocardial infarction in patients, remains unresolved. Hence, we aimed to
determine whether higher adiponectin levels predict cardiovascular events and
mortality in these patients.
Methods: At Al-Nasiriyah Heart Hospital, 60 patients diagnosed with acute
myocardial infarction (AMI) and 60 healthy controls participated in a case
control study. ELISA was used to measure serum ADIPOQ levels, and
fluorescent immunoassay was used to measure Hs-TnI levels. Serum creatinine,
blood urea, estimated glomerular filtration rate (eGFR), and fasting blood
glucose were also measured.
Results: When comparing AMI patients with the control group, the mean body
mass index (BMI), glomerular filtration rate, urea, creatinine, and Hs-TnI levels
were significantly higher. On the other hand, adiponectin levels and estimated
glomerular filtration rate were considerably lower in patients who had
experienced an acute myocardial infarction.
Conclusion: Patients with MI have significantly lower serum AdipoQ levels,
which are linked to elevated cardiac injury markers (Hs-TnI) and compromised
renal function.
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