Study Of TiO2 Nanoparticles Induction For Biological System

  • Lames Majid Hammed Thi-Qar University, College of medicine
  • Hassan Tuhmaz Hamad Thi-Qar University, College of medicine
Keywords: TiO2 nanoparticles, Cell viability, HEK-293

Abstract

Background:   The biological activity of NPs strongly depends on physicochemical parameters but these are not routinely considered in toxicity screening, such as dose metrics which is studied by many researchers.Titanium dioxide nanoparticles (nano-TiO2) are extensively used in the cosmetics, pharmaceutical, and paint industries as a coloring material due to its high stability, anticorrosion and photocatalytic properties Aim:    This study represents the study of TiO2  nanoparticles induction for biological systems.                                                                                                                                        Method:Curve fitting in matlab program is used to study the effect of parameters of the system on the cell levels with existence TNPs.                                                                            Results: The Consequences showed that nanoparticles induce human embryonic kidney cells (HEK-293) the generation of reactive oxygen species (ROS) followed by significant depletion of glutathione levels and increased lipid peroxidation. From the results, we observe that the behavior of can be predicated by estimating the     equations which described the variation of culler effecting by increased the TNPs concentration at different exposure times.            

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Published
2019-08-02
Section
Articles