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December 17, 2025
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December 17, 2025
Published
December 14, 2025
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Abstract

Ischemic heart diseases (IHD) a condition that happens when the heart doesn't
get enough blood. Inflammation is the underlying common mechanism
involved in IHD. Kynurenine pathway, as a major route of tryptophan
degradation, its metabolites have been revealed to be crucial in CVD and
involved in several biological processes such as immune-regulation,
inflammation, and metabolism. Different enzymes have been shown to
participate in the kynurenine pathway such as KMO, 3-HHAO. The study
aimed to identify whether the metabolites of tryptophan degradation have an
association with development of inflammatory event of IHD and its progress A
case-control study was conducted at cardiac center in Thi-Qar Governorate,
with participants:90 patients with IHD divided into 3 groups, myocardial
infraction (M, n=30), angina (AN, n=30) and heart failure (HF, n=30. A 60
sample (n=60) were collected from healthy people as control group. KMO, and
3HHAO were identified by ELISA, while tryptophan concentration was
measured by HPLC technique. Statistical tests were applied by using one-way
ANOVA and ROC curve analysis. Tryptophan concentration was decreased
significantly (P value < 0.001) in patient groups compared to control group.
The levels of KMO and 3-HHAO were significantly elevated (P value <
0.001) in patients than control. These findings suggest inflammatory events
in IHD induced tryptophan catabolism through the kynurenine pathway which
plays a significant role in modulating immune response and influencing the
development of CVD.

Keywords

Ischemic heart disease Tryptophan KMO 3HAAO

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Copyright (c) 2025 Ali Jabbar Maeedi , Anwar Jasib Thaaban Almzaiel

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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