Evaluation of Cerebral Vasoreactivity in Type2 Diabetic Patients by using Transcranial Doppler Ultrasonography (TCD)


  • Zahraa Abdulaali Al- Mudheffer Assistant Proffessor Physiology Department / Kufa College of Medicine
  • Noor Jawad Kadhum M.B.Ch.B Physiology Department / Thi-Qar College of Medicine
  • Hayder Kadhum Hasson Professor Clinical Neurology / Middle Euphrate Neuroscience Center


Diabetes mellitus, Cerebral vasoreactivity, Transcranial Doppler Ultrasonography.


Background Type 2 diabetes mellitus (T2DM) is associated with an increased risk of cardiovascular and cerebrovascular diseases with high mortality and disability. Cerebral vasomotor reactivity (VMR), one of the most accurate markers of cerebral hemodynamics, has been shown to be impaired in subjects with carotid artery steno-occlusive disease and associated with an increased risk of ischemic events. Transcranial Doppler ultrasonography )TCD( study have been used to  investigate cerebral vasoreactivity to identify patients with increased risk and to better plan the treatment. Objective: The aim of study was to assess cerebral vasoreactivity  among type2 diabetes mellitus patients by using transcranial Doppler ultrasonography. Patients and method: sixty five persons (45 type 2 diabetic patients and 20 normal control) (32 male,33 female) with mean age (46.95 ±7.459) enrolled in this study. The study groups are collected randomly from Al Najaf center  for Diabetic and endocrine in Al Sader teaching hospital during the time between January 2016 to June 2016. TCD  examination was performed  in Middle Euphrates Neuroscience Center for all stuied group to assess cerebral vasoreactivity  in middle cerebral artery by breath holing test,hyperventilation test (HV), Transient  hyperemic test (THRR). (Statistical Package of Social Sciences) SPSS version 23 was used for the statistical analysis. Results : There was highly significant change of breath holding index BHI{ between control group and diabetic group} (p.value<0.05) and significant change of HV between control group and diabetic group . Also statistical significant change in THRR in relation to glycemic control(p.value< 0.05). Conclusion : There was significant changes in TCD indices that assessed cerebral vasoreactivity  in breath holding index, ,hyperventilation in  type2 diabetic patients compared with control subjects.


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