Hemoglobinopathies According To Blood Groups In Thi-Qar Governorate
Keywords:
Hemoglobinopathies, Thalassemia, Sickle cell diseaseAbstract
The hemoglobinopathies are a group of disorders that acquired through families in which there is abnormal creation or structure of the hemoglobin molecule, which cause a considerable public health problem. The carriers of Hb diseases worldwide are estimated to be 269 million with about 400,000 births a year. The birth of effected child, consequently, places extensive physical, physiological and fiscal burden, not only on the affected child and its family, but also on the society and the nation at large. Methodology: In this cross- sectional study 601 patients with hemoglobinopathies (317 males and 284 females), Whose age ranged from months to ≥40 years. They were attending genetic blood disease center at Al- Habobi hospital in Thi-Qar governorate during the data collection period (1st March to 31 May 2016). Results: Thalassemia has high prevalence than other hemoblobinopathies (76.53) and majority of cases was blood group O. The highly percentage of cases was at age ≤ 10 years (54.08) followed by 21-30 years was (34.44), highly percentage of cases was in urban (60.90). Recommendations: Adequate and suitable therapeutic and preventive measures should be taken to diminish birth of effected children such as health education of individuals about importance of premarital screening program for all couple to identify gen carrier individual of hemoglobinopathies.References
Maria D, Fernando F. The genetics of blood disorders: hereditary hemoglobinopathies. Jornal de Pediatria. 2008 - Vol. 84, Issue. 4 .
Chiyome L, Thalassemias and Other Hemoglobinopathies Protocol. Hawai‘i State Department of Health, Children with Special Health Needs Branch, Genetics Program.2008
Bikash M, Soumyajit M, Biplab K et al. Prevalence of hemoglobinopathy, ABO and rhesus blood groups in rural areas of West Bengal, India. J Res Med Sci. 2012 , Vol 17 No (8):P 772–776.
Holton, J.B., Walter, J.H., Tyfield, L.A, et al. The Hemoglobinopathies. The Metabolic and Molecular Bases of Inherited Disease, 8th ed. McGraw-Hill, New York. 2001.
Eric D. Jacobsen, Hemoglobinopathies. www.turner-white.com H Hematology, 2010 Volume 5, Part 3.
Elisabeth K. Hemoglobinopathies Clinical Manifestations, Diagnosis, and Treatment, Deutsches Ärzteblatt International Dtsch Arztebl Int 2011; Vol 108 , P:31–32.
Ambroise W. Hemoglobinopathies: molecular genetics and prenatal diagnosis, 2007; Vol 27; p982.
Tan, Sickle cell trait and small for gestational age babies: Is there a link? Journal of Obstetrics and Gynecology 2008. Vol 28, No 3, P:298-300.
Kaur M, Dangi C and Singh M. An Overview on Sickle Cell Disease Profile, Asian J Pharm Clin Res, 2013. Vol 6, Suppl 1, P: 25-37.
Lorna B, Claire C, Bernard D. Standards for the Clinical Care of Adults with Sickle Cell Disease in the UK, Sickle Cell Society 2008.
Standards of Care Guidelines for Thalassemia, 2012.
Renzo G and Raffaella O. “Beta-thalassemia”. Galanello and Origa Orphanet Journal of Rare Diseases 2010.
Sathi T, Vishnu D, Siva G an Overview on Thalassemia. International Research Journal for Inventions in Pharmaceutical Sciences. 2013;Vol (1);Issue 1:p1-12.
Karthika M, Ksh G, Deisha B. Prevalence of Hemoglobinopathies in Manipur. IOSR Journal of Dental and Medical Sciences, 2012. Volume 14, Issue 8, P17-20
. Saovaros S, Orapan S.Genomic Study in β-Thalassemia, Advances in the Study of Genetic Disorders, Dr. Kenji Ikehara (Ed.). In Tech open science. 2011;p149-168.
Urkude V, Mishra A. RNA Silencing: An Approach for the Treatment of β-Thalassemia. J Cell Science & Therapy .2012; Volume (3) ; Issue 7:P 2-4.
Balgir RS. Spectrum of Hemoglobinopathies in the state of Orissa, India: A Ten years cohort study. J Assoc Physicians India. 2005.
Shaista Muhammad N, Abdul S. Type and frequency of hemoglobinopathies, diagnosed in the area of Karachi, in Pakistan, Cogent Medicine 2016 .
