Expression of Transforming Growth Factor Alpha and Their Receptor (EGFR) in Thyroid Carcinoma and Benign Patients


  • Kareem Hamed Ghali Department of Biology, College of Science, Wasit University
  • Tahani Abduljabbar Nasser Department of Biology, College of Science, Wasit University
  • Hameed Naeem Mousa Department of Pathology and Forensic Medicine, College of Medicine, Thi - Qar University


Thyroid cancer, TGF, EGFR, Immunohistochemistry


The current study was included 178 patients, 111 patients out them were affected with thyroid cancer, 46 patients were benign neoplastic and 21 individuals were no cancers and benign as control group. The study was carried out in Laboratory of College of Science, University of Wasit in collaboration with AL-Hussein Teaching Hospital and Ibn al-Bitar Laboratory Specialist in Thi Qar Province, from January 2015 to April 2016. Immunohistochemical technique was used to determination the expression of TGFα and their receptor EGFR in all studied cases. The study aimed to estimation the expression of these proteins in thyroid carcinogenesis and the possibility of transforming the benign patients to thyroid cancer. The results showed overexpression in TGFα in thyroid cancer when compared with benign patients and control group with significant differences (p< 0.05). Regarding EGFR, the results explained no significant differences when compared between three samples. Our results concluded there is a strong relationship between TGFα overexpression and thyroid carcinogenesis.



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