Study of levels of malondialdehyde (MDA) among pateints with acute myocardial infarction
Abstract
SUMMARY : Serum malondialdehyde (MDA), as an index of lipid peroxidation, and the serum enzymes creatinin kinase (CK) , lactate dehydrogenase ( LDH ), were evaluated in a group of 32 patients with acute myocardial infarction (AMI) , 12 with angina pectoris (AP), and 88 healthy subjects as a control group . MDA values were within the normal range in those with angina pectoris patients, while in those with acute myocardial infarction patients a significant increase in serum MDA was observed in the days following the acute event, reaching a peak level in 6-8 days later, a significant relation was found between the integrated concentration-time MDA curve and the integrated serum enzymes activity curves reached during the nine days after the acute event. The "in vivo" relevance of the increased serum MDA in the post-infarct period is unknown at the present, but as lipid peroxides are known to harm cellular structures and to inhibit prostacyclin synthesis.References
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