The Incidence (Extent) of Crystalluria, following Co-Trimoxazole or Trimethoprim Administration in Children with (4-10) years old age in Bint Al- Huda teaching hospital in Thi-Qa

Authors

  • Adnan M. Al-Rekabi
  • Jawad F. H. Al-Musawi

Keywords:

Co-trimoxazole, Trimethoprim, crystalluria

Abstract

       This present study, reflect the incidence of crystalluria among children (4-10) years old, in which the extent of crystalluria were more in patients who were suffered from G.I.T. infections 65(56.52%), more than those patients who were suffered from R.T.I. and were treated by co-trimoxazole. Also this study showing as, that the  patients who were treated by only co-trimoxazole, were highly exposed to crystalluria 88(76.52%), more than those patients who were treated by both co-trimoxazole and I.V. fluid 27(23.43%). Also we found that crystalluria were developed more in female patients 74(64.34%), than male patients 41(35.62%).

References

-Laurence D.R., Bennett P.N. et al, Clinical Pharmacology,"Sulphonamide and sulphonamide combination" (Churchill Lingstone), 9th Ed. 2003, 231-32.

- Jick H and Derby LE, "A Large Population-Based Follow-Up Study of Trimethoprim-Sulfamethoxazole, Trimethoprim, and Cephalexin for Uncommon Serious Drug Toxicity," Pharmacotherapy, 1995, 15(4):428-32.

- Jick H and Derby LE, "Is Co-Trimoxazole Safe?" Lancet, 1995, 345(8957):1118-9.

- Dawkins B, Albury D, and Olsen TE, "Trimethoprim/Sulfamethoxazole-Induced renal injury - A Case Report Supported by the Laboratory Diagnosis," Aust N Z J Med, 1995, 25:83.

- Brumfitt W, Hamilton-Miller JM (December 1993). "Reassessment of the rationale for the combinations of sulphonamides with diaminopyrimidines". J Chemother 5 (6): 465–9. PMID 8195839.

- Dawkins B, Albury D, and Olsen TE, "Trimethoprim/Sulfamethoxazole-Induced renal injury and crystallizations- A Case Report Supported by the Laboratory Diagnosis," Aust N Z J Med, 1995, 25:83.

- Cockerill FR and Edson RS, "Trimethoprim-Sulfamethoxazole in Pediatrics," Mayo Clin Proc, 1991, 66(12):1260-9.

- Domingo P, Ferrer S, Cruz J, et al, "Trimethoprim-Sulfamethoxazole-Induced Renal Tubular Acidosis in a Patient With AIDS," Clin Infect Dis, 1995, 20(5):143, 45-7.

-"Co-trimoxazole use restricted". Drug Ther Bull 33 (12): 92–3. December 1995. doi:10.1136/dtb.1995.331292. PMID 8777892.

-"Co-Trimoxazole and Infectious Diseases". ScienceOfInfec.com. 2011-09-20. Retrieved 2012-08-07.

- Fogazzi GB. Crystalluria: a neglected aspect of urinary sediment analysis.Nephrol Dial Transplant1996; 11: 379–83.

- Noto H, Kaneko Y, Takano T, et al, "Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients With Severe Gastroenteritis ," Intern Med, 1995, 34(2):96-9.

- Naber K, Vergin H, and Weigand W, "Pharmacokinetics of Co-trimoxazole and Co-tetroxazine in pediatric Patients," Infection, 1981, 9(5):239-43.

- Hennessy S, Strom BL, Berlin JA, et al, "Crystalluria following antiepileptic agents," J Gen Inter Med, 1995, 10(7):380-6.

- Leonard G. Gomella, Steen H. Haist, Armee G. Adams, Kelly M. Smith "Clinician Pocket Reference" (Side Effect of Trimethoprim and Cotrimoxazole)-Copyright Ed.- 2007, 192.

- Varoquaux O, Lajoie D, Gobert C, et al, Sexual variation of drugs-induced crystalluria" : A Randomized Trial," Br J Clin Pharmacol, 1985, 20:575-81.

- Böhni E (1969). "Chemotherapeutic activity of the combination of trimethoprim and sulfamethoxazole in infections of mice". Postgrad Med J45 (Suppl): Suppl:18–21. PMID 4902845.

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Published

2021-03-24

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