Immunological Study of Helicobacter Pylori Infections on Pregnancy With Gestational Diabetes Mellitus


  • Hajar Dawood salman AL-Shujiri Department of Microbiology, College of Medicine, University of Babylon, Iraq
  • Ifad Kerim Abd Al-shibly University of Babylon, College of medicine, Department of microbiology
  • Huda H. Al-Hasnawy University of Babylon, College of medicine, Department of microbiology


Gestational Diabetes Mellitus (GDM), H. Pylori


Background: The term "gestational diabetes mellitus" (GDM) refers to any degree of glucose intolerance that manifests itself or is first noticed during pregnancy. is a severe obstetric complication that affects between 5 and 10 percent of pregnancies globally; and is characterized by an insufficient response to insulin (Hyperglycemia). to make up for pregnancy's insulin-resistant condition. Gram-negative, spiral-shaped, microaerophilic H. pylori bacteria.Having dimensions of 0.5 to 1 pm in width and 2 to 4 pm in length. The body contains 2 to 6 flagella, and the flagella's motility grants and permits quick movement in viscous solutions, like the mucus layer of the gastric epithelial cell. Objective: The purpose of this study was to determine the relationship between [Helicobacter pylori (H. pylori) with Gestational diabetes mellitus (GDM)]. Materials and Method: HP-IgG and HP-IgM levels were evaluated in 89 pregnancy womens: 60 with Gestational Diabetes Mellitus (GDM) disease and 29 with healthy pregnancy. The study participants and the healthy controls varied in ages from 23 to 47 year. The enzyme-linked immunosorbent assay (ELISA) method measured HP-IgG and HP-IgM levels  in the blood. Results: The serum HP-IgG was greater in GDM patients than in controls (p 0.01) and HP-IgM (p 0.05). the current study discovered a Positive association between HP-IgG and HP-IgM with GDM. Conclusion: H. pylori infections are very common in GDM. The women with GDM, infections with H. pylori are rise the risks of GDM. The  H. pylori selection and extermination therapy before pregnancy help in avoiding GDM


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