Impact of Personal Characteristics on the First and Second Doses of Pfizer-BioNTech Vaccine-Related Side Effects among Health Staff in Sulaimani City, Iraq
Keywords:COVID-19 vaccine, Pfizer, SARS-CoV-2, Side effects
AbstractBackground: The safety and effectiveness of vaccines that have been used against COVID-19 are important for controlling the SARS-CoV-2 pandemic. Unlike classical vaccines, the Pfizer BioNTech vaccine contains the genetic information required to synthesize the SARS-CoV-2 spike protein, usually found on the viral surface. This vaccine is used in Iraq to prevent the virus spread. Aim of the study: This study aims to analyze the association between individual backgrounds and side effects after receiving the first and second doses of the Pfizer-BioNTech vaccine. Participants and Methods: A prospective cohort study was conducted between April 25th, 2021, and September 28th, 2021, among 110 health staff in Sulaimani city. The SPSS version 22 was used for data entry and analysis. Results: The incidence of side effects was significantly higher females, in individuals older than 35 years, participants with a previous history of SARS-CoV-2 infection, and administrative personnel. Concerning local side effects after the first dose, itching, and after the second dose, pain, and tightness in the injected limb were significantly higher in individuals in the age group >35 years (P<0.05). Regarding systemic side effects, after the first dose, myalgia and insomnia were significantly higher in the age group >35 years, and arthralgia was significantly higher in unhealthy participants (P<0.05). After the second dose, diarrhea was significantly higher in females, and arthralgia was significantly higher in the age group >35 years (P<0.05). Conclusion: The Pfizer vaccine causes several temporary side effects, the occurrence of side effects is more frequent in females, people greater than 35 years of age, individuals with a prior history of SARS-CoV-2 infection, and administrative staff.
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