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Abstract

Background; Thyroid and parathyroid dysfunction in hemodialysis patients is a critical medical
concern that arises due to the intricate relationship between kidney function and these endocrine
glands. Hemodialysis, a life-saving procedure for individuals with kidney failure, often disrupts
the delicate balance of hormones in the body. Thyroid dysfunction, characterized by alterations in
thyroid hormone levels, is common and can lead to fatigue, weight changes, and mood swings. On
the other hand, parathyroid dysfunction involves imbalances in calcium and phosphorus
metabolism, resulting in bone and cardiovascular complications. Monitoring and managing thyroid
and parathyroid health in hemodialysis patients is crucial to improving their overall well-being and
quality of life.
Methodology:
Case-control the study was conducted on 75 patients undergoing hemodialysis and 75 age-matched
healthy controls. Thyroid function tests and serum electrolytes were measured for each group.
Results;
Our results show a significant difference between patients and the control group in each oxidative
stress marker and serum electrolyte level.
Conclusions:
From the results, we could conclude that thyroid and parathyroid dysfunction play a role in
hemodialysis and can affect the management of end-stage renal failure patients.

Keywords

Hemodialysis thyroid dysfunction parathyroid dysfunction electrolytes

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References

  1. Abdel, H., Deraz, A., & Shawky, N. M. (2023). Assessment of Thyroid Disorders and Chronic
  2. Kidney Disease : Review Article. 92(July), 5778–5783.
  3. Akram, M., Munir, N., Daniyal, M., Egbuna, C., Găman, M.-A., Onyekere, P. F., & Olatunde, A.
  4. (2020). Vitamins and Minerals: Types, Sources and their Functions. Functional Foods and
  5. Nutraceuticals, August, 149–172. https://doi.org/10.1007/978-3-030-42319-3_9
  6. Ataei, N., Bazargani, B., Ameli, S., Madani, A., Javadilarijani, F., Moghtaderi, M., Abbasi, A.,
  7. Shams, S., & Ataei, F. (2014). Early detection of acute kidney injury by serum cystatin C in
  8. critically ill children. Pediatric Nephrology, 29(1), 133–138. https://doi.org/10.1007/s00467-013-
  9. -5
  10. Atif, M. (2016). The hemodialysis machine case study. Lecture Notes in Computer Science
  11. (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics),
  12. , 329–343. https://doi.org/10.1007/978-3-319-33600-8_29
  13. Badiu, C. (2018). The Thyroid and its Diseases - A Comprehensive Guide for the Clinician 1st
  14. Edition. Acta Endocrinologica (Bucharest), 14(4), 574–574. https://doi.org/10.4183/aeb.2018.574
  15. Balwan, W. K., & Kour, S. (2022). Thyroid Health & Methylation: What is the Link? Scholars
  16. Journal of Applied Medical Sciences, 10(12), 2460–2468.
  17. https://doi.org/10.36347/sjams.2022.v10i12.065
  18. Bertinato, J. (2021). Iodine nutrition: Disorders, monitoring and policies. In Advances in Food and
  19. Nutrition Research (1st ed., Vol. 96). Elsevier Inc. https://doi.org/10.1016/bs.afnr.2021.01.004
  20. Bichari, W., Khedr, E., Sayed, H., Elwasly, D., & Ezzat, H. (2020). Prevalence of thyroid function
  21. abnormalities in patients with chronic renal failure under regular hemodialysis. Egyptian Journal
  22. of Hospital Medicine, 80(1), 594–598. https://doi.org/10.21608/EJHM.2020.90163
  23. Bikbov, B., Purcell, C. A., Levey, A. S., Smith, M., Abdoli, A., Abebe, M., Adebayo, O. M.,
  24. Afarideh, M., Agarwal, S. K., Agudelo-Botero, M., Ahmadian, E., Al-Aly, Z., Alipour, V.,
  25. Almasi-Hashiani, A., Al-Raddadi, R. M., Alvis-Guzman, N., Amini, S., Andrei, T., Andrei, C. L.,
  26. … Murray, C. J. L. (2020). Global, regional, and national burden of chronic kidney disease, 1990–
  27. : a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 395(10225),
  28. –733. https://doi.org/10.1016/S0140-6736(20)30045-3
  29. Covella, B., Vinturache, A. E., Cabiddu, G., Attini, R., Gesualdo, L., Versino, E., & Piccoli, G. B.
  30. (2019). A systematic review and meta-analysis indicates long-term risk of chronic and end-stage
  31. kidney disease after preeclampsia. Kidney International, 96(3), 711–727.
  32. https://doi.org/10.1016/j.kint.2019.03.033
  33. Dhillon-Jhattu, S., McGill, R. L., Ennis, J. L., Worcester, E. M., Zisman, A. L., & Coe, F. L.
  34. (2023). Vitamin D and Parathyroid Hormone Levels in CKD. American Journal of Kidney
  35. Diseases, 81(1), 122–124. https://doi.org/10.1053/j.ajkd.2022.06.006
  36. Disease, K. (2023). Spectrum of Thyroid Dysfunction in Patients with Chronic Kidney Disease in
  37. Benin City, Nigeria. 1–13.
  38. Dwi Payana, I. M., Tuti Arianthi, N. N., & Sila Darmana, I. M. (2020). High ureum and creatinine
  39. level in 18-year-old male: first diagnosed with chronic kidney disease. Intisari Sains Medis, 11(1),
  40. https://doi.org/10.15562/ism.v11i1.708
  41. Ephraim, E., & Jewell, D. E. (2021). High Protein Consumption with Controlled Phosphorus Level
  42. Increases Plasma Concentrations of Uremic Toxins in Cats with Early Chronic Kidney Disease.
  43. March. https://doi.org/10.24966/FSN-1076/100096
  44. Fedak, D., Kuźniewski, M., Fugiel, A., Wieczorek-Surdacka, E., Przepiorkowska-Hoyer, B., Jasik,
  45. P., Miarka, P., Dumnicka, P., Kapusta, M., Solnica, B., & Sułowicz, W. (2016). Serum uromodulin
  46. concentrations correlate with glomerular filtration rate in patients with chronic kidney disease.
  47. Polskie Archiwum Medycyny Wewnetrznej, 126(12), 995–1004.
  48. https://doi.org/10.20452/pamw.3712
  49. Gosmanova, E. O., Chen, K., Rejnmark, L., Mu, F., Swallow, E., Briggs, A., Ayodele, O., Sherry,
  50. N., & Ketteler, M. (2021). Risk of Chronic Kidney Disease and Estimated Glomerular Filtration
  51. Rate Decline in Patients with Chronic Hypoparathyroidism: A Retrospective Cohort Study.
  52. Advances in Therapy, 38(4), 1876–1888. https://doi.org/10.1007/s12325-021-01658-1
  53. Hasani, N. J., Alkhafaji, N. A. K., & Anied, A. (2022). Chronic Kidney Disease and associated
  54. Oxidative Stress with low levels of some important vital indicators. Journal of Pharmaceutical
  55. Negative Results, 13(7), 312–316. https://doi.org/10.47750/pnr.2022.13.S07.042
  56. Iglesias, P., & Díez, J. J. (2009). Thyroid dysfunction and kidney disease. European Journal of
  57. Endocrinology, 160(4), 503–515. https://doi.org/10.1530/EJE-08-0837
  58. Jacquillet, G., & Unwin, R. J. (2019). Physiological regulation of phosphate by vitamin D,
  59. parathyroid hormone (PTH) and phosphate (Pi). Pflugers Archiv European Journal of Physiology,
  60. (1), 83–98. https://doi.org/10.1007/s00424-018-2231-z
  61. Jager, K. J., Kovesdy, C., Langham, R., Rosenberg, M., Jha, V., & Zoccali, C. (2019). A single
  62. number for advocacy and communication-worldwide more than 850 million individuals have
  63. kidney diseases. Nephrology Dialysis Transplantation, 34(11), 1803–1805.
  64. https://doi.org/10.1093/ndt/gfz174
  65. Jameson, M. G., Holloway, L. C., Vial, P. J., Vinod, S. K., & Metcalfe, P. E. (2010). A review of
  66. methods of analysis in contouring studies for radiation oncology. Journal of Medical Imaging and
  67. Radiation Oncology, 54(5), 401–410. https://doi.org/10.1111/j.1754-9485.2010.02192.x
  68. Kachhawa, P., & Sinha, V. (2019). Assessment of thyroid dysfunction, dyslipidemia and oxidative
  69. stress in hypertensive end stage chronic renal disease patients in a teaching hospital in Western
  70. Uttar Pradesh. Asian Journal of Medical Sciences, 10(5), 13–18.
  71. https://doi.org/10.3126/ajms.v10i5.24688
  72. Kashif, M., Hussain, M. S., Anis, M., & Shah, P. K. (2023). Thyroid Dysfunction and Chronic
  73. Kidney Disease: A Study Among the Northeastern Population of India. Cureus, 15(5), 1–7.
  74. https://doi.org/10.7759/cureus.38700
  75. Khatiwada, S., Rajendra, K. C., Gautam, S., Lamsal, M., & Baral, N. (2015). Thyroid dysfunction
  76. and dyslipidemia in chronic kidney disease patients. BMC Endocrine Disorders, 15(1), 1–7.
  77. https://doi.org/10.1186/s12902-015-0063-9
  78. Khatri, P., Chaudhary, S., Piryani, R. M., Jaiswal, N. K., Alamkhan, M., Shahi, A., Dhakal, P. R.,
  79. & Koirala, S. (2019). Thyroid Function Abnormalities in Patients with End-Stage Renal Disease
  80. Undergoing Hemodialyis. 18(9), 61–64. https://doi.org/10.9790/0853-
  81. www.iosrjournals.org61
  82. Kopple, J. D., Kalantar-Zadeh, K., & Mehrotra, R. (2005). Risks of chronic metabolic acidosis in
  83. patients with chronic kidney disease. Kidney International, Supplement, 67(95), 21–27.
  84. https://doi.org/10.1111/j.1523-1755.2005.09503.x
  85. Kritmetapak, K., & Pongchaiyakul, C. (2019). Parathyroid Hormone Measurement in Chronic
  86. Kidney Disease: From Basics to Clinical Implications. International Journal of Nephrology, 2019.
  87. https://doi.org/10.1155/2019/5496710
  88. Laibi, H., Jewad, A. M., & Salih, M. (2023). Role of Routine Markers in the Diagnosis of Patients
  89. with Chronic Kidney Disease. Journal of Biomedicine and Biochemistry, 2(1), 28–35.
  90. https://doi.org/10.57238/jbb.2023.6532.1027
  91. Levey, A. S., Titan, S. M., Powe, N. R., Coresh, J., & Inker, L. A. (2020). Kidney disease, race,
  92. and gfr estimation. Clinical Journal of the American Society of Nephrology, 15(8), 1203–1212.
  93. https://doi.org/10.2215/CJN.12791019
  94. Luyckx, V. A., & Brenner, B. M. (2020). Clinical consequences of developmental programming
  95. of low nephron number. Anatomical Record, 303(10), 2613–2631.
  96. https://doi.org/10.1002/ar.24270
  97. Luyckx, V. A., Tonelli, M., & Stanifer, J. W. (2018). The global burden of kidney disease and the
  98. sustainable development goals. Bulletin of the World Health Organization, 96(6), 414-422C.
  99. https://doi.org/10.2471/BLT.17.206441
  100. Mehan, S., Guo, T., Gitau, M. W., & Flanagan, D. C. (2017). Comparative study of different
  101. stochasticweather generators for long-term climate data simulation. Climate, 5(2), 1–40.
  102. https://doi.org/10.3390/cli5020026
  103. Mehsen, J. T., Madhi, Z. S., & Madhi, I. S. (2020). Spinal Stenosis : What Outcome Should be
  104. Expected ? Review the Latest Evidence Using the Assessment of Multiple Systematic Reviews
  105. Appraisal Tool ( AMSTAR ). 117–121. https://doi.org/10.4103/MJBL.MJBL
  106. Mohamed, A., Eldin, B., Shafik, D. E., Sabry, I. M., Abdl, M., Rouf, E., Mahmoud, H., &
  107. Mahmoud, A. (2023). Evaluation of Thyroid Functions in Patients with End Stage Renal Disease
  108. in A Sample of Egyptian Populations. 90(January), 1382–1386.
  109. Mohamedali, M., Reddy Maddika, S., Vyas, A., Iyer, V., & Cheriyath, P. (2014). Thyroid disorders
  110. and chronic kidney disease. International Journal of Nephrology, 2014, 1–7.
  111. https://doi.org/10.1155/2014/520281
  112. N, R. S., & Gb, K. (2023). Journal of Medical - Clinical Research & Reviews Lipid Profile in
  113. Chronic Renal Failure Patients on Haemodialysis. 7(6), 6–9.
  114. Onose, G., Munteanu, C., Popescu, C., Rotariu, M., Turnea, M., Dogaru, G., Iliescu, G., Minea,
  115. M., Ionescu, E. V., Oprea, C., Stanciu, L. E., & Sînziana, C. (2023). Exploring the Potential
  116. Benefits of Natural Calcium-Rich Mineral Waters for Health and Wellness : A Systematic Review.
  117. –18.
  118. Palmer, B. F., & Clegg, D. J. (2019). Physiology and Pathophysiology of Potassium Homeostasis :
  119. Core Curriculum 2019. American Journal of Kidney Diseases, 74(5), 682–695.
  120. https://doi.org/10.1053/j.ajkd.2019.03.427
  121. Palsson, R., & Waikar, S. S. (2018). Renal Functional Reserve Revisited. Advances in Chronic
  122. Kidney Disease, 25(3), e1–e8. https://doi.org/10.1053/j.ackd.2018.03.001
  123. Pasala, S., & Carmody, J. B. (2017). How to use... serum creatinine, cystatin C and GFR. Archives
  124. of Disease in Childhood: Education and Practice Edition, 102(1), 37–43.
  125. https://doi.org/10.1136/archdischild-2016-311062
  126. Perry, K. W., & Salusky, I. B. (2011). Chronic Kidney Disease Mineral and Bone Disorder.
  127. Pediatric Bone: Biology and Diseases, 795–820. https://doi.org/10.1016/B978-0-12-382040-
  128. 10029-2
  129. Pisoschi, A. M., Pop, A., Iordache, F., Stanca, L., Predoi, G., & Serban, A. I. (2021). Oxidative
  130. stress mitigation by antioxidants - An overview on their chemistry and influences on health status.
  131. European Journal of Medicinal Chemistry, 209, 112891.
  132. https://doi.org/10.1016/j.ejmech.2020.112891
  133. Rana, S., Soni, B., Darney, D. P. E., & Jeyan, J. V. M. (2022). Experimental Investigation of
  134. Effects of T3 Hormones on Human Body and their Analysis. International Journal of Science and
  135. Research (IJSR), Https://Www. Ijsr. Net/Get_abstract. Php, June, 785–789.
  136. https://doi.org/10.21275/SR22610152007
  137. Rashighi, M., & Harris, J. E. (2017). 乳鼠心肌提取 HHS Public Access. Physiology & Behavior,
  138. (3), 139–148. https://doi.org/10.1053/j.gastro.2016.08.014.CagY
  139. Rhee, C. M., Brent, G. A., Kovesdy, C. P., Soldin, O. P., Nguyen, D., Budoff, M. J., Brunelli, S.
  140. M., & Kalantar-Zadeh, K. (2015). Thyroid functional disease: An under-recognized cardiovascular
  141. risk factor in kidney disease patients. Nephrology Dialysis Transplantation, 30(5), 724–737.
  142. https://doi.org/10.1093/ndt/gfu024
  143. Scherbaum, W. A. (2023). Epidemiologie und Verlauf des Diabetes mellitus in Deutschland
  144. Herausgeber: W. A Scherbaum, W. Kiess Autoren: G. Giani, H. U. Janka, H. Hauner, E. Standl,
  145. R. Schiel, A. Neu, W. Rathmann, J. Rosenbauer. Diabetes.
  146. https://doi.org/10.1002/14651858.CD014475.www.cochranelibrary.com
  147. Shrivastava, S., & Khare, N. (2023). Biochemical Assessments of Thyroid Profile and Renal
  148. Function Test in Chronic Kidney Disease. International Journal of Current Science Research and
  149. Review, 06(03), 2051–2054. https://doi.org/10.47191/ijcsrr/v6-i3-24
  150. Suki, W. N., & Moore, L. W. (2016). Fósforo en erc . 6–9.
  151. Tippannavar, S. H., & Shekhanawar, M. (2022). A study of Thyroid dysfunction in patients with
  152. chronic kidney disease undergoing maintenance haemodialysis among the patients of tertiary care
  153. hospital. International Journal of Advanced Biochemistry Research, 6(1), 10–12.
  154. https://doi.org/10.33545/26174693.2022.v6.i1a.78
  155. Vanholder, R., Gryp, T., & Glorieux, G. (2018). Urea and chronic kidney disease: The comeback
  156. of the century? (in uraemia research). Nephrology Dialysis Transplantation, 33(1), 4–12.
  157. https://doi.org/10.1093/ndt/gfx039
  158. Vega, M. W., Swartz, S. J., Devaraj, S., & Poyyapakkam, S. (2020a). Elevated serum creatinine:
  159. But is it renal failure? Pediatrics, 146(1). https://doi.org/10.1542/peds.2019-2828
  160. Vega, M. W., Swartz, S. J., Devaraj, S., & Poyyapakkam, S. (2020b). Elevated serum creatinine:
  161. But is it renal failure? Pediatrics, 146(1), 146–148. https://doi.org/10.1542/peds.2019-2828
  162. Wan, J., Li, W., & Zhong, Y. (2019). Parathyroidectomy decreases serum intact parathyroid
  163. hormone and calcium levels and prolongs overall survival in elderly hemodialysis patients with
  164. severe secondary hyperparathyroidism. Journal of Clinical Laboratory Analysis, 33(3), 1–6.
  165. https://doi.org/10.1002/jcla.22696
  166. Wein, M. N., & Kronenberg, H. M. (2018). Regulation of bone remodeling by parathyroid
  167. hormone. Cold Spring Harbor Perspectives in Medicine, 8(8).
  168. https://doi.org/10.1101/cshperspect.a031237
  169. Yamada, S., & Nakano, T. (2023). Role of Chronic Kidney Disease ( CKD )– Mineral and Bone
  170. Disorder ( MBD ) in the Pathogenesis of Cardiovascular Disease in CKD. 1–16

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