Identifying Potential Biomarkers for Cutaneous Leishmaniasis Diagnosi
Keywords:
Cutaneous Leishmaniasis, biomarkersAbstract
Cutaneous Leishmaniasis represents one of the widespread epidemic disease in Iraqcaused by the protozoan Leishmania parasite. However, There are clinical difficulties in
distinguish between this disease and other skin diseases can leave permanent skin scars.
This study aims to identify potential biomarkers for Cutaneous Leishmaniasis diagnosis
and prognosis and to know the progression of the disease and the distribution of
inflammation within the skin cells. In this review, 17 proteins have been selected using
literature searching such as pubmed and web of science to identify potential biomarkers
for Cutaneous Leishmaniasis diagnosis and prognosis and further studies needed to find
the role of these protein in the development of the disease.
References
Silva, H., Liyanage, A., Deerasinghe, T., Sumanasena, B., Munidasa, D.,
de Silva, H., and Karunaweera, N. (2021). Therapeutic response to thermotherapy in cutaneous
leishmaniasis treatment failures for sodium stibogluconate: a randomized controlled proof of
principle clinical trial. The American J. Trop. Med and Hygiene , 104 (3) , 945 - 950 pp.
Al-Yasiri, F. J. M., Alghezi, D. A., & Al-Abadi, F. A. M. (2022). Diagnostic
usefulness of immunohistochemical (IHC) assessment of CD1a and CD68 biomarkers for
cutaneous leishmaniasis. International Journal of Health Sciences, 6(S7), 3605–3613.
https://doi.org/10.53730/ijhs.v6nS7.12590
Georgiadou,SP;Makaritsis,K.P;and Dalekos,G.N. (2015). Leishmaniasis
revisited : Current aspect on epidemiology ,diagnosis and treatment J. trans. Int. med .3 (2): 43 -
pp.
Wamai, R.G.; Kahn, J.; McGloin, J.; and Ziaggi, G. (2020). Visceral Leishmaniasis:
A Global overview , J .Glob. Heal. Sci., 2 (1): 1- 22 pp.
Al-Nahas ,S.(2006). Isoenzyme typing and leishmaniasis diagnosis. J. labrotory
diagnostics. 4 (2),1 - 8 pp.
Ghorbani, M and Farhoudi R. ( 2018). Leishmaniasis in humans: drug or vaccine
therapy? Drug Design, Development and Therapy 2018:12 25–40.
Rashidi, S., Mansouri, R., Ali-Hassanzadeh, M., Ghani, E., Karimazar, M.,
Muro, A., and Manzano-Román, R. (2022). miRNAs in the regulation of mTOR signaling and
host immune responses: the case of Leishmania infections. Acta Tropica, 106431.
James, W. D., Elston, D., Treat, J. R., Rosenbach, M. A. and Neuhaus,
I. (2019). Andrews’ Diseases of the Skin E-Book: Clinical Dermatology. Elsevier Health Sciences.
Janardhan, K. S., Jensen, H., Clayton, N. P., and Herbert, R. A. (2018).
Immunohistochemistry in investigative and toxicologic pathology. Toxicologic pathology, 46 (5),
- 510 pp.
Yoo, H. J., Kim, N. Y., and amp; Kim, J. H. (2021, May 31). Current understanding of
the roles of CD1A-restricted T cells in the immune system. Molecules and cells. Retrieved
August 18, 2022.
Behar S, Porcelli SA.(2007). T cell activation by CD1 and lipid antigens.
Springer; CD1-restricted T cells in host defense to infectious diseases. T Cell Activation by CD1
and Lipid Antigens, 215-150 pp.
De Jong, A., and Ogg, G. (2021). CD1a function in human skin disease.
Molecular Immunology, 130, 14-19 pp
Amanzada, A., MalikI, A., Blaschke, M. (2013). Dentification of CD68 (+)
neutrophilgranulocytes in invitro mode ofacute inflammation and inflammatory bowel disease. Nt
J .Cin Exp Pathol ; 6:561570.
Chistiakov, D. A., Killingsworth, M. C., Myasoedova, V. A., Orekhov, A. N., and
Bobryshev, Y. V. (2017). CD68/macrosialin: not just a histochemical marker. Laboratory
investigation, 97(1), 4-13.
Faiz, F. (2021, October 7). CD68 cluster designation 68. University of
Kerbala.RetrieveJuly28,2022,fromhttps://uokerbala.edu.iq/archives/14167
Gregory, D. J., and Olivier, M. (2015). Subversion of host cell signalling by the
protozoan parasite Leishmania. Parasitology, 130 (S1), 27-35 pp.
Wolday, D. ; Akuffo , H. ; Demissie , A. and Britton, S. (2004). Role of Leishmania
donovani and its lipophosphoglycan in CD4+ T-cell activation-induced human
immunodeficiency virus replication. Infect. Immun ., (67): 5258-5264.
AL Lami S.(2021). Epidemiological and diagnostic and genetics study for
leishmania parasite in Misan government. M.Sc. College of Education for pure science.
University of Thi-Qar. 76 pp.
Haghdoust, S., Noroozbeygi, M., Hajimollahoseini, M., Masooleh, M. M.,
and Yeganeh, F. (2022). A candidate vaccine composed of live nonpathogenic Iranian Lizard
Leishmania mixed with Chitin microparticles protects mice against Leishmania major
infection. Acta Tropica, 227, 106298.
Ronet, C., Passelli, K., Charmoy, M., Scarpellino, L., Myburgh, E., La
Torre, Y. H., and Tacchini-Cottier, F. (2019) . TLR2 signaling in skin nonhematopoietic cells
induces early neutrophil recruitment in response to Leishmania major infection. J. Investigative
Dermatology, 139 (6), 318- 328 pp.
Haddy,N.J. (2006). An epidemiological and serological study of visceral leishmaniasis
in Dhi Qar Governorate.( M.Sc thesis,Thi-Qar University).
Khamaes, E. S., Al-Bayati, N. Y., and Abbas, A. H. (2022). Tissue inhibitor
of metalloproteinase-1 (TIMP-1) serum level and genetic polymorphisms associated with
cutaneous Leishmania infections. Human Gene, 33, 201049
Beldi, N., Mansouri, R., Bettaieb, J., Yaacoub, A., Souguir Omrani, H.,
Saadi Ben Aoun, Y. and Guerbouj, S. (2017). Molecular characterization of Leishmania
parasites in Giemsa-stained slides from cases of human cutaneous and visceral leishmaniasis,
Eastern Algeria. Vect. Bor.Z oonot. Di s., 17 (6), 416 – 424 pp.
Ford, J., Hughson, A., Lim, K., Bardina, S. V., Lu, W., Charo, I. F., and
Fowell, D. J. (2019). CCL7 is a negative regulator of cutaneous inflammation following
Leishmania major infection. Frontiers in immunology, 9, 306 .
Al- Al-Mosawi, A, M ,J. (2015,a). Molecular and Immunological Study of
Cutaneous Leishmaniasis in the middle and Southern Provinces PHD thesis ,Kerbala
University.82 pp.
Al-Mosawi, N. AJ. AK. (2015, b) Investigate of Cutaneous Leishmaniasis and
knowledge of the role heat shock protein HSP70 in the immune response in the province of Thi
Qar . M.Sc. College of Education for pure science. University of Thi-Qar. 90 pp.
Schwenkenbecher, J. M., Fröhlich, C., Gehre, F., Schnur, L. F., and Schönian, G.
(2004). Evolution and conservation of microsatellite markers for Leishmania tropica. Infection,
Genetics and Evolution, 4(2), 99-105 pp.
De Carvalho Gallo, J. C., de Mattos Oliveira, L., Araújo, J. S. C.,
Santana, I. B., and dos Santos Junior, M. C. (2018). Virtual screening to identify Leishmania
braziliensis N-myristoyltransferase inhibitors: pharmacophore models, docking, and molecular
dynamics. J. molecular modeling, 24 (9), 1-10 pp.
Passelli, K., Prat-Luri, B., Merlot, M., Goris, M., Mazzone, M., and
Tacchini-Cottier, F. (2022). The c-MET receptor tyrosine kinase contributes to neutrophildriven pathology in cutaneous leishmaniasis. PLoS Pathogens, 18(1), e1010247.
Saravanan, P., Venkatesan, S. K., Mohan, C. G., Patra, S., and Dubey, V.
K. (2010). Mitogen-activated protein kinase 4 of Leishmania parasite as a therapeutic
target. European J.med. chemistry, 45(12), 5662-5670 pp.
Raj, S., Sasidharan, S., Dubey, V. K., and Saudagar, P. (2019). Identification of lead
molecules against potential drug target protein MAPK4 from L. donovani: An in-silico approach
using docking, molecular dynamics and binding free energy calculation. PloS one, 14(8),
e0221331.
Diotallevi, A., Buffi, G., Ceccarelli, M., Neitzke-Abreu, H. C., Gnutzmann,
L. V., Junior, M. S. D. C. L., and Galluzzi, L. (2020). Data on the differentiation among
Leishmania Viannia spp., Leishmania infantum and Leishmania amazonensis in Brazilian clinical
samples using real-time PCR. Data in brief, 28, 104 pp.
Taheri, E., Dabiri, S., Meymandi, M. S., & Saedi, E. (2017). Possible interrelationship
of inflammatory cells in dry type cutaneous leishmaniasis. Iranian Journal of Pathology, 12(2),
Fernandez-Flores A, Rodriguez-Peralto JL.(2016). Morphological and
immunohistochemical clues for the diagnosis of cutaneous leishmaniasis and the interpretation of
CD1a status. J .Am Acad. Dermatol. 74: 536–5pp.
Sundharkrishnan L, (2017). North JP. Histopathologic features of cutaneous
leishmaniasis and use of CD1a staining for amastigotes in Old World and New World
leishmaniasis. J Cutan Pathol. Dec ;44 (12) : 1005-1011 pp.
Farokhpour, F., Rajabi, P., Naeini, B. A., and Naimi, A. (2021). Comparison of
expression of CD1a and CD68 markers in skin leishmaniasis samples with positive and negative
Leishman body. Am. J. Clin and Experimental Immunol 10 (2), 5 pp.
Karabulut YY, Bozkurt FK, Türsen Ü, Bayram G, Temel GÖ, and Erdal
ME. (2021).’The role of CD1a expression in the diagnosis of cutaneous leishmaniasis, its
relationship with leishmania species and clinicopathological features. Dermatol Ther ;34(4) :
e14977.
Gadelha, S. D. A. C., Cunha, M. D. P. S. S. D., Coelho, G. M., Marinho, T.
M. S., and Hirth, C. G. (2019). Evaluation of the diagnostic potential of CD1a
immunohistochemistry for visceral leishmaniasis. Revista do Instituto de Medicina Tropical de
São Paulo, 61 pp.
Khalid,N.D .(2018). systemic and local immuneResponse in individuals
infected with scabies (master thesis,Diyala university) . 134 pp
Downloads
Published
Issue
Section
License
Copyright (c) 2023 University of Thi-Qar Journal Of Medicine
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.