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June 30, 2025
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Abstract

Back ground End-stage kidney disease (ESKD) is most commonly caused by diabetic kidney disease (DKD) in affluent nations, including the US. It is a microvascular complication that can arise in people with type 1 diabetes (T1DM) or type 2 diabetes (T2DM).Aims of the study: Understanding the connection between vitamin D and Cytokine levels in diabetic nephropathy patients.Result : The study's 90 participants (40 women and 50 men) showed a wide variety of ages, with most of them being between 45 and 82. The study compared the relationship between diabetic nephropathy and several kidney function parameters in males and females, showing differences in the levels 8-OHDG, AGEs and oxidative stress Biomarkers. The comparison of oxidative stress biomarker (MDA, 8OHDG, AOPP, HNE4 and AGE) between patient and control groups has been carried out. Conclusions: It has been observed that the values of kidney efficiency parameters are affected in diabetic patients after a number of years, and as a result this leads to an increase in the values of these parameters, which ultimately leads to kidney damage or severe damage, which makes the people concerned need to undergo dialysis or even a kidney transplant, or in late cases it may lead to death.

Keywords

Diabetic nephropathy, 8-OHDG, AGEs

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Copyright (c) 2025 Lina A. Naser, Bushra A. M. Abdul Azeez, Ali Jameel Hameed

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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