Endometriosis, role of surgical treatment in restoring female fertility in AL-Nasiriya city

Authors

  • Alaa Hussein Ali Gynecologist, F.I.C.M.S, ThiQar medical college

Keywords:

endometriosis, surgical treatment, fertility

Abstract

Endometriosis is a hormonal and immune system disease in which cells similar to that which line the uterus (endometrium) grow outside the uterine cavity, most commonly on the membrane which lines the abdominal cavity, the peritoneum. The uterine cavity is lined with endometrial cells, which are under the influence of female hormones. Endometrial cells in areas outside the uterus are also influenced by hormonal changes and respond in a way that is similar to the cells found inside the uterus. Common symptoms of endometriosis are pain and infertility. The pain often is worse with the menstrual cycle and is the most common cause of secondary dysmenorrhea.Endometriosis is typically diagnosed during the reproductive years, but has been diagnosed in girls as young as 8 and has been found to continue past menopause, it has been estimated that endometriosis occurs in roughly 4–10% of women.[1] Symptoms may depend on the site of active endometriosis. Its main but not universal symptom is pelvic pain in various manifestations. There is an established association betweene.endometriosis and infertility.[1] Endometriosis has a significant social and psychological impact.[2]There is no cure for endometriosis, but it can be treated in a variety of ways, including pain medication, hormonal treatments, and surgery.[3]This study was done on 76 infertile females more than 5 years  , general seminal analysis of those females partners  were  normal ( active form of sperms are more than 50% with good number of sperms , high percentage of normal morphology of sperms in general seminal analysis) examination of those females genital tracts and sex hormonal  assay with prolactin hormone all normal except the endometriosis of the wall of uterus with the parietal peritoneum and posterior layer of anterior abdominal wall  one  year(feberury2011-feberury2012) spend for collection of data and other 2 years( feberary2012-feberury 2014) for fallow up the patients for pregnancy . age of patients range between 28—38 years  , 13.2% of patients had previous caesarian section.We get from this study 63.1% were get pregnant  after the surgical treatments of endometriosis within 2 years post operatively. 37.5% were pregnant at first 6 months post operative , 29.2% at 2nd 6 months  after operation and 33.3 at the 2nd year after operation .

References

Bulletti C, Coccia ME, Battistoni S, Borini A (August 2010). "Endometriosis and infertility". J. Assist. Reprod. Genet. 27 (8): 441–7. doi:10.1007/s10815-010-9436-1.PMC 2941592. PMID 20574791.

Culley L, Law C, Hudson N, Denny E, Mitchell H, Baumgarten M, Raine-Fenning N (2013). "The social and psychological impact of endometriosis on women's lives: A critical narrative review". Human Reproduction Update 19 (6): 625–639.doi:10.1093/humupd/dmt027. PMID 23884896.

"Endometriosis fact sheet". NIH. Retrieved Feb 12, 2013.

Stratton P, Berkley KJ (2011). "Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications". Hum. Reprod. Update 17 (3): 327–46.doi:10.1093/humupd/dmq050. PMC 3072022. PMID 21106492.

Endometriosis;NIH Pub. No. 02-2413; September 2002

Ballard K, Lane H, Hudelist G, Banerjee S, Wright J (June 2010). "Can specific pain symptoms help in the diagnosis of endometriosis? A cohort study of women with chronic pelvic pain". Fertil. Steril. 94 (1): 20–7. doi:10.1016/j.fertnstert.2009.01.164.PMID 19342028.

Murray, Michael T.; Pizzorno, Joseph (2012). The Encyclopedia of Natural Medicine (3rd ed.). New York, NY: Simon and Schuster.

Endometriosis: Does It Cause Infertility?, from American Society for Reproductive Medicine. Revised 2012

Women with Endometriosis Have Higher Rates of Some Diseases; NIH News Release; 26 September 2002; http://www.nih.gov/news/pr/sep2002/nichd-26.htm

Arbique, D., Carter, S., & van Sell, S. (2008). Endometriosis can evade diagnosis: being alert to signs of endometriosis can arrest the disease before it takes over a patient's life. Rn, 71(9), 28-32.

Colette S, Donnez J (July 2011). "Are aromatase inhibitors effective in endometriosis treatment?". Expert Opin Investig Drugs 20 (7): 917–31.doi:10.1517/13543784.2011.581226. PMID 21529311.

Pearce CL, Templeman C, Rossing MA, Lee A, Near AM, Webb PM, Nagle CM, Doherty JA, Cushing-Haugen KL, Wicklund KG, Chang-Claude J, Hein R, Lurie G, Wilkens LR, Carney ME, Goodman MT, Moysich K, Kjaer SK, Hogdall E, Jensen A, Goode EL, Fridley BL, Larson MC, Schildkraut JM, Palmieri RT, Cramer DW, Terry KL, Vitonis AF, Titus LJ, Ziogas A, Brewster W, Anton-Culver H, Gentry-Maharaj A, Ramus SJ, Anderson AR, Brueggmann D, Fasching PA, Gayther SA, Huntsman DG, Menon U, Ness RB, Pike MC, Risch H, Wu AH, Berchuck A (2012). "Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies".Lancet Oncol. 13 (4): 385–94. doi:10.1016/S1470-2045(11)70404-1. PMC 3664011.PMID 22361336.

Article by Prof. Farr Nezhat, MD, FACOG, FACS, University of Columbia, May 1, 2012

Audebert A (April 2005). "La femme endométriosique est-elle différente ?" [Women with endometriosis: are they different from others?]. Gynécologie, Obstétrique & Fertilité (in French) 33 (4): 239–46. doi:10.1016/j.gyobfe.2005.03.010. PMID 15894210.

Rowlands, IJ; Nagle, CM; Spurdle, AB; Webb, PM; Australian National Endometrial Cancer Study Group; Australian Ovarian Cancer Study Group (Dec 2011). "Gynecological conditions and the risk of endometrial cancer". Gynecol Oncol 3: 537–41.

Benagiano G, Brosens I, Habiba M (2014). "Structural and molecular features of the endomyometrium in endometriosis and adenomyosis". Hum. Reprod. Update 20 (3): 386–402. doi:10.1093/humupd/dmt052. PMID 24140719.

Sinaii N, Cleary SD, Ballweg ML, Nieman LK, Stratton P (October 2002). "High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis". Human Reproduction 17(10): 2715–24. doi:10.1093/humrep/17.10.2715. PMID 12351553.

Acosta S, Leandersson U, Svensson SE, Johnsen J (May 2001). "Fallbeskrivning. Endometrios orsakade kolonileus, uretärobstruktion och hypertoni" [A case report. Endometriosis caused colonic ileus, ureteral obstruction and hypertension].Läkartidningen (in Swedish) 98 (18): 2208–12. PMID 11402601.

Ueda Y, Enomoto T, Miyatake T, et al. (June 2010). "A retrospective analysis of ovarian endometriosis during pregnancy". Fertility and Sterility 94 (1): 78–84.doi:10.1016/j.fertnstert.2009.02.092. PMID 19356751.

Visouli, AN; Zarogoulidis, K; Kougioumtzi, I; Huang, H; Li, Q; Dryllis, G; Kioumis, I; Pitsiou, G; Machairiotis, N; Katsikogiannis, N; Papaiwannou, A; Lampaki, S; Zaric, B; Branislav, P; Porpodis, K;

Zarogoulidis, P (October 2014). "Catamenial pneumothorax.".Journal of thoracic disease 6 (Suppl 4): S448–60. PMID 25337402.

Fauser BC, Diedrich K, Bouchard P, Domínguez F, Matzuk M, Franks S, Hamamah S, Simón C, Devroey P, Ezcurra D, Howles CM (2011). "Contemporary genetic technologies and female reproduction". Hum. Reprod. Update 17 (6): 829–47.doi:10.1093/humupd/dmr033. PMC 3191938. PMID 21896560.

Kapoor D, Davila W (2005). Endometriosis, eMedicine.

Giudice LC, Kao LC (2004). "Endometriosis". Lancet 364 (9447): 1789–99.doi:10.1016/S0140-6736(04)17403-5. PMID 15541453.

Rahmioglu, N.; Nyholt, D. R.; Morris, A. P.; Missmer, S. A.; Montgomery, G. W.; Zondervan, K. T. (2014). "Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets". Human Reproduction Update 20 (5): 702–716. doi:10.1093/humupd/dmu015. ISSN 1355-4786.

Painter JN, Anderson CA, Nyholt DR, et al. (January 2011). "Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis". Nature Genetics 43(1): 51–4. doi:10.1038/ng.731. PMC 3019124. PMID 21151130.

Treloar SA, Wicks J, Nyholt DR, et al. (September 2005). "Genomewide linkage study in 1,176 affected sister pair families identifies a significant susceptibility locus for endometriosis on chromosome 10q26". American Journal of Human Genetics 77 (3): 365–76. doi:10.1086/432960. PMC 1226203. PMID 16080113.

Anger DL, Foster WG (2008). "The link between environmental toxicant exposure and endometriosis". Frontiers in Bioscience 13: 1578–93. doi:10.2741/2782.PMID 17981650.

Sherry E. Rier, Dan C. Martin, Robert E. Bowman, W.Paul Dmowski, Jeanne L. Becker (1993). "Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin". Fundamental and Applied Toxicology 21 (4). pp. 433–441. doi:10.1006/faat.1993.1119.

Sherry E. Rier, Wayman E. Turner, Dan C. Martin, Richard Morris, George W. Lucier and George C. Clark (2001). "Serum Levels of TCDD and Dioxin-like Chemicals in Rhesus Monkeys Chronically Exposed to Dioxin: Correlation of Increased Serum PCB Levels with Endometriosis". Toxicological Sciences 51 (1). pp. 147–159.doi:10.1093/toxsci/59.1.147.

Bois FY, Eskenazi B (May 1994). "Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin". Environmental Health Perspectives 102(5): 476–7. doi:10.1289/ehp.94102476. PMC 1567136. PMID 8593852.

Guo SW (2004). "The link between exposure to dioxin and endometriosis: a critical reappraisal of primate data". Gynecologic and Obstetric Investigation 57 (3): 157–73.doi:10.1159/000076374. PMID 14739528.

Guo SW, Simsa P, Kyama CM, et al. (October 2009). "Reassessing the evidence for the link between dioxin and endometriosis: from molecular biology to clinical epidemiology".Molecular Human Reproduction 15 (10): 609–24. doi:10.1093/molehr/gap075.PMID 19744969.

Rier S, Foster WG (December 2002). "Environmental dioxins andendometriosis".Toxicological Sciences 70 (2): 161–70. doi:10.1093/toxsci/70.2.161. PMID 12441361.

Bulun SE, Zeitoun K, Sasano H, Simpson ER (1999). "Aromatase in aging women".Seminars in Reproductive Endocrinology 17 (4): 349–58. doi:10.1055/s-2007-1016244.PMID 10851574.

Batt RE, Mitwally MF (December 2003). "Endometriosis from thelarche to midteens: pathogenesis and prognosis, prevention and pedagogy". Journal of Pediatric and Adolescent Gynecology 16 (6): 337–47. doi:10.1016/j.jpag.2003.09.008.PMID 14642954.

Marsh EE, Laufer MR (March 2005). "Endometriosis in premenarcheal girls who do not have an associated obstructive anomaly". Fertility and Sterility 83 (3): 758–60.doi:10.1016/j.fertnstert.2004.08.025. PMID 15749511.

Burney RO, Giudice LC (September 2012). "Pathogenesis and pathophysiology of endometriosis". Fertil. Steril. 98 (3): 511–9. doi:10.1016/j.fertnstert.2012.06.029.PMC 3836682. PMID 22819144.

van der Linden PJ (1996). "Theories on the pathogenesis of endometriosis". Human reproduction (Oxford, England). 11 Suppl 3: 53–65. doi:10.1093/humrep/11.suppl_3.53.PMID 9147102.

Gleicher N, el-Roeiy A, Confino E, Friberg J (July 1987). "Is endometriosis an autoimmune disease?". Obstet Gynecol 70 (1): 115–22. PMID 3110710.

Capellino S, Montagna P, Villaggio B, Sulli A, Soldano S, Ferrero S, Remorgida V, Cutolo M (June 2006). "Role of estrogens in inflammatory response: expression of estrogen receptors in peritoneal fluid macrophages from endometriosis". Annals of the New York Academy of Sciences 1069: 263–7. doi:10.1196/annals.1351.024. PMID 16855153.

Young VJ, Brown JK, Saunders PT, Horne AW (2013). "The role of the peritoneum in the pathogenesis of endometriosis". Human Reproduction Update 19 (5): 558–569.doi:10.1093/humupd/dmt024. PMID 23720497.

Redwine DB (October 2002). "Was Sampson wrong?". Fertility and Sterility 78 (4): 686–93. doi:10.1016/S0015-0282(02)03329-0. PMID 12372441.

Signorile PG, Baldi F, Bussani R, D'Armiento M, De Falco M, Baldi A (April 2009)."Ectopic endometrium in human foetuses is a common event and sustains the theory of müllerianosis in the pathogenesis of endometriosis, a disease that predisposes to cancer". Journal of Experimental & Clinical Cancer Research 28: 49. doi:10.1186/1756-9966-28-49. PMC 2671494. PMID 19358700.

"Diagnosis and Treatment of Endometriosis". American Academy of Family Physicians. 1999-10-15. Retrieved 2011-07-26.

Laschke MW, Giebels C, Menger MD (2011). "Vasculogenesis: a new piece of the endometriosis puzzle". Hum. Reprod. Update 17 (5): 628–36.doi:10.1093/humupd/dmr023. PMID 21586449.

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2021-03-07

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